Pathophysiological Role of Caveolae in Hypertension
Caveolae, flask-shaped cholesterol-, and glycosphingolipid-rich membrane microdomains, contain caveolin 1, 2, 3 and several structural proteins, in particular Cavin 1–4, EHD2, pacsin2, and dynamin 2. Caveolae participate in several physiological processes like lipid uptake, mechanosensitivity, or si...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-07-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fmed.2019.00153/full |
| _version_ | 1818367308567937024 |
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| author | Xiaoming Lian Claudia Matthaeus Mario Kaßmann Oliver Daumke Maik Gollasch Maik Gollasch |
| author_facet | Xiaoming Lian Claudia Matthaeus Mario Kaßmann Oliver Daumke Maik Gollasch Maik Gollasch |
| author_sort | Xiaoming Lian |
| collection | DOAJ |
| description | Caveolae, flask-shaped cholesterol-, and glycosphingolipid-rich membrane microdomains, contain caveolin 1, 2, 3 and several structural proteins, in particular Cavin 1–4, EHD2, pacsin2, and dynamin 2. Caveolae participate in several physiological processes like lipid uptake, mechanosensitivity, or signaling events and are involved in pathophysiological changes in the cardiovascular system. They serve as a specific membrane platform for a diverse set of signaling molecules like endothelial nitric oxide synthase (eNOS), and further maintain vascular homeostasis. Lack of caveolins causes the complete loss of caveolae; induces vascular disorders, endothelial dysfunction, and impaired myogenic tone; and alters numerous cellular processes, which all contribute to an increased risk for hypertension. This brief review describes our current knowledge on caveolae in vasculature, with special focus on their pathophysiological role in hypertension. |
| first_indexed | 2024-12-13T22:49:59Z |
| format | Article |
| id | doaj.art-53bd258f886645a6bbca46dd23965a8a |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-12-13T22:49:59Z |
| publishDate | 2019-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-53bd258f886645a6bbca46dd23965a8a2022-12-21T23:28:39ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2019-07-01610.3389/fmed.2019.00153451115Pathophysiological Role of Caveolae in HypertensionXiaoming Lian0Claudia Matthaeus1Mario Kaßmann2Oliver Daumke3Maik Gollasch4Maik Gollasch5Experimental and Clinical Research Center—A Joint Cooperation Between the Charité–University Medicine Berlin and the Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, GermanyMax Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, GermanyExperimental and Clinical Research Center—A Joint Cooperation Between the Charité–University Medicine Berlin and the Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, GermanyMax Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, GermanyExperimental and Clinical Research Center—A Joint Cooperation Between the Charité–University Medicine Berlin and the Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, GermanyMedical Clinic for Nephrology and Internal Intensive Care, Berlin, GermanyCaveolae, flask-shaped cholesterol-, and glycosphingolipid-rich membrane microdomains, contain caveolin 1, 2, 3 and several structural proteins, in particular Cavin 1–4, EHD2, pacsin2, and dynamin 2. Caveolae participate in several physiological processes like lipid uptake, mechanosensitivity, or signaling events and are involved in pathophysiological changes in the cardiovascular system. They serve as a specific membrane platform for a diverse set of signaling molecules like endothelial nitric oxide synthase (eNOS), and further maintain vascular homeostasis. Lack of caveolins causes the complete loss of caveolae; induces vascular disorders, endothelial dysfunction, and impaired myogenic tone; and alters numerous cellular processes, which all contribute to an increased risk for hypertension. This brief review describes our current knowledge on caveolae in vasculature, with special focus on their pathophysiological role in hypertension.https://www.frontiersin.org/article/10.3389/fmed.2019.00153/fullcaveolaecaveolin 1endothelial nitric oxide synthaseCa2+ channelshypertension |
| spellingShingle | Xiaoming Lian Claudia Matthaeus Mario Kaßmann Oliver Daumke Maik Gollasch Maik Gollasch Pathophysiological Role of Caveolae in Hypertension Frontiers in Medicine caveolae caveolin 1 endothelial nitric oxide synthase Ca2+ channels hypertension |
| title | Pathophysiological Role of Caveolae in Hypertension |
| title_full | Pathophysiological Role of Caveolae in Hypertension |
| title_fullStr | Pathophysiological Role of Caveolae in Hypertension |
| title_full_unstemmed | Pathophysiological Role of Caveolae in Hypertension |
| title_short | Pathophysiological Role of Caveolae in Hypertension |
| title_sort | pathophysiological role of caveolae in hypertension |
| topic | caveolae caveolin 1 endothelial nitric oxide synthase Ca2+ channels hypertension |
| url | https://www.frontiersin.org/article/10.3389/fmed.2019.00153/full |
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