Drug–drug interaction study of ciprofol and sodium divalproex: Pharmacokinetics, pharmacodynamics, and safety in healthy Chinese subjects
Abstract Ciprofol (also known as HSK3486) is a promising intravenous anesthetic candidate derived from propofol and independently developed by Haisco Pharmaceutical Group Co., Ltd. (Chengdu, China). Compared with propofol, ciprofol has the potential to reduce the dose required and the associated ris...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-10-01
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| Series: | Clinical and Translational Science |
| Online Access: | https://doi.org/10.1111/cts.13605 |
| _version_ | 1797657456486121472 |
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| author | Dandan Yang Wei Zhang Zourong Ruan Bo Jiang Siqi Huang Jiaying Wang Pengfei Zhao Mengyue Hu Min Yan Honggang Lou |
| author_facet | Dandan Yang Wei Zhang Zourong Ruan Bo Jiang Siqi Huang Jiaying Wang Pengfei Zhao Mengyue Hu Min Yan Honggang Lou |
| author_sort | Dandan Yang |
| collection | DOAJ |
| description | Abstract Ciprofol (also known as HSK3486) is a promising intravenous anesthetic candidate derived from propofol and independently developed by Haisco Pharmaceutical Group Co., Ltd. (Chengdu, China). Compared with propofol, ciprofol has the potential to reduce the dose required and the associated risks. Ciprofol is extensively metabolized in vivo, and its interaction with other concurrently administered drugs during clinical application is worthy of attention. Therefore, an open‐label, two‐stage sequential study was performed in healthy subjects who received either a single administration of ciprofol injection or ciprofol injection after oral administration of sodium divalproex. The aim of the study was to evaluate the effects of sodium divalproex on ciprofol with respect to pharmacokinetics, pharmacodynamics, and safety, thus providing a basis for the rational clinical use of ciprofol and sodium divalproex. |
| first_indexed | 2024-03-11T17:45:49Z |
| format | Article |
| id | doaj.art-53c13a137c874b1f8bdff728158fbd10 |
| institution | Directory Open Access Journal |
| issn | 1752-8054 1752-8062 |
| language | English |
| last_indexed | 2024-03-11T17:45:49Z |
| publishDate | 2023-10-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Translational Science |
| spelling | doaj.art-53c13a137c874b1f8bdff728158fbd102023-10-18T07:31:18ZengWileyClinical and Translational Science1752-80541752-80622023-10-0116101972198110.1111/cts.13605Drug–drug interaction study of ciprofol and sodium divalproex: Pharmacokinetics, pharmacodynamics, and safety in healthy Chinese subjectsDandan Yang0Wei Zhang1Zourong Ruan2Bo Jiang3Siqi Huang4Jiaying Wang5Pengfei Zhao6Mengyue Hu7Min Yan8Honggang Lou9Center of Clinical Pharmacology, The Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou Zhejiang ChinaCenter of Clinical Pharmacology, The Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou Zhejiang ChinaCenter of Clinical Pharmacology, The Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou Zhejiang ChinaCenter of Clinical Pharmacology, The Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou Zhejiang ChinaDepartment of Anesthesiology, The Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou Zhejiang ChinaCenter of Clinical Pharmacology, The Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou Zhejiang ChinaCenter of Clinical Pharmacology, The Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou Zhejiang ChinaSichuan Haisco Pharmaceutical Co., Ltd. Chengdu ChinaDepartment of Anesthesiology, The Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou Zhejiang ChinaCenter of Clinical Pharmacology, The Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou Zhejiang ChinaAbstract Ciprofol (also known as HSK3486) is a promising intravenous anesthetic candidate derived from propofol and independently developed by Haisco Pharmaceutical Group Co., Ltd. (Chengdu, China). Compared with propofol, ciprofol has the potential to reduce the dose required and the associated risks. Ciprofol is extensively metabolized in vivo, and its interaction with other concurrently administered drugs during clinical application is worthy of attention. Therefore, an open‐label, two‐stage sequential study was performed in healthy subjects who received either a single administration of ciprofol injection or ciprofol injection after oral administration of sodium divalproex. The aim of the study was to evaluate the effects of sodium divalproex on ciprofol with respect to pharmacokinetics, pharmacodynamics, and safety, thus providing a basis for the rational clinical use of ciprofol and sodium divalproex.https://doi.org/10.1111/cts.13605 |
| spellingShingle | Dandan Yang Wei Zhang Zourong Ruan Bo Jiang Siqi Huang Jiaying Wang Pengfei Zhao Mengyue Hu Min Yan Honggang Lou Drug–drug interaction study of ciprofol and sodium divalproex: Pharmacokinetics, pharmacodynamics, and safety in healthy Chinese subjects Clinical and Translational Science |
| title | Drug–drug interaction study of ciprofol and sodium divalproex: Pharmacokinetics, pharmacodynamics, and safety in healthy Chinese subjects |
| title_full | Drug–drug interaction study of ciprofol and sodium divalproex: Pharmacokinetics, pharmacodynamics, and safety in healthy Chinese subjects |
| title_fullStr | Drug–drug interaction study of ciprofol and sodium divalproex: Pharmacokinetics, pharmacodynamics, and safety in healthy Chinese subjects |
| title_full_unstemmed | Drug–drug interaction study of ciprofol and sodium divalproex: Pharmacokinetics, pharmacodynamics, and safety in healthy Chinese subjects |
| title_short | Drug–drug interaction study of ciprofol and sodium divalproex: Pharmacokinetics, pharmacodynamics, and safety in healthy Chinese subjects |
| title_sort | drug drug interaction study of ciprofol and sodium divalproex pharmacokinetics pharmacodynamics and safety in healthy chinese subjects |
| url | https://doi.org/10.1111/cts.13605 |
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