Drug–drug interaction study of ciprofol and sodium divalproex: Pharmacokinetics, pharmacodynamics, and safety in healthy Chinese subjects

Drug–drug interaction study of ciprofol and sodium divalproex: Pharmacokinetics, pharmacodynamics, and safety in healthy Chinese subjects

Abstract Ciprofol (also known as HSK3486) is a promising intravenous anesthetic candidate derived from propofol and independently developed by Haisco Pharmaceutical Group Co., Ltd. (Chengdu, China). Compared with propofol, ciprofol has the potential to reduce the dose required and the associated ris...

Full description

Bibliographic Details
Main Authors:	Dandan Yang, Wei Zhang, Zourong Ruan, Bo Jiang, Siqi Huang, Jiaying Wang, Pengfei Zhao, Mengyue Hu, Min Yan, Honggang Lou
Format:	Article
Language:	English
Published:	Wiley 2023-10-01
Series:	Clinical and Translational Science
Online Access:	https://doi.org/10.1111/cts.13605

Similar Items

Pharmacokinetics, pharmacodynamics, and safety of ciprofol emulsion in Chinese subjects with normal or impaired renal function
by: Jun Tao, et al.
Published: (2023-11-01)

A pharmacokinetic and pharmacodynamic drug interaction between rosuvastatin and valsartan in healthy subjects
by: Jung JA, et al.
Published: (2015-03-01)

Rifampin-divalproex drug-drug interaction in an adult patient: A case report
by: Christine Doran, PharmD, et al.
Published: (2021-01-01)

Pharmacokinetic, Pharmacokinetic/Pharmacodynamic, and Safety Investigations of Lefamulin in Healthy Chinese Subjects
by: Yingying Hu, et al.
Published: (2023-08-01)

Pharmacokinetics, Safety and Pharmacokinetics/Pharmacodynamics Analysis of Omadacycline in Chinese Healthy Subjects
by: Haijing Yang, et al.
Published: (2022-04-01)

Pharmacokinetics and Pharmacodynamics of Anaesthetic drugs in Paediatrics
by: Rebecca Jacob, et al.
Published: (2004-01-01)

Suicidality and divalproex sodium: analysis of controlled studies in multiple indications
by: Kovacs Xenia, et al.
Published: (2011-01-01)

Pharmacokinetic and pharmacodynamic drug–drug interactions between evogliptin and empagliflozin or dapagliflozin in healthy male volunteers
by: Dasohm Kim, et al.
Published: (2023-08-01)

Pharmacodynamic and Pharmacokinetic Drug Interactions between Fexuprazan, a Novel Potassium-Competitive Inhibitor, and Aspirin, in Healthy Subjects
by: JungJin Oh, et al.
Published: (2023-02-01)

First-in-human study to investigate the safety and pharmacokinetics of salvianolic acid A and pharmacokinetic simulation using a physiologically based pharmacokinetic model
by: Jinliang Chen, et al.
Published: (2022-11-01)

Evaluation of the pharmacokinetic and pharmacodynamic drug interactions between cilnidipine and valsartan, in healthy volunteers
by: Lee J, et al.
Published: (2014-10-01)

Pharmacokinetics and Pharmacodynamics of Lisdexamfetamine Compared with D-Amphetamine in Healthy Subjects
by: Patrick C. Dolder, et al.
Published: (2017-09-01)

Pharmacokinetic and Pharmacodynamic Drug–Drug Interactions: Research Methods and Applications
by: Lei Sun, et al.
Published: (2023-07-01)

Release property study on the novel divalproex sodium enteric-coated capsules
by: Shuoye Yang, et al.
Published: (2016-05-01)

Pharmacokinetics and pharmacodynamics of antimalarial drugs in pregnant women
by: Kloprogge, F
Published: (2013)

PHARMACOKINETICS AND PHARMACODYNAMICS OF DRUGS IN PATIENTS WITH RENAL DYSFUNCTION
by: K. Zakon, et al.
Published: (2017-12-01)

Ciprofol- a game changing intravenous anesthetic or another experimental drug!
by: Abhijit Nair, et al.
Published: (2022-01-01)

Pharmacokinetic and Pharmacodynamic Characteristics of Pelubiprofen Tromethamine vs. Pelubiprofen in Healthy Subjects
by: Yu-Jeong Son, et al.
Published: (2023-04-01)

Pharmacokinetic and pharmacodynamic interaction between ezetimibe and rosuvastatin in healthy male subjects
by: Kim CH, et al.
Published: (2017-12-01)

Pharmacokinetic/Pharmacodynamic Interaction Between Evogliptin and Pioglitazone in Healthy Male Subjects
by: Hwang I, et al.
Published: (2020-10-01)

Pharmacokinetic and pharmacodynamic drug-drug interaction of Nomilin with atorvastatin in hyperlipidemic mice
by: Yan Ding, et al.
Published: (2023-11-01)

Comorbid epilepsy and depression—pharmacokinetic and pharmacodynamic drug interactions
by: Barbara Miziak, et al.
Published: (2022-10-01)

Pharmacokinetics, pharmacodynamics, and safety of prandial oral insulin (N11005) in healthy subjects
by: Qi Pan, et al.
Published: (2023-07-01)

Single- and multiple-dose pharmacokinetics, pharmacodynamics, and safety of apixaban in healthy Chinese subjects
by: Cui Y, et al.
Published: (2013-12-01)

Population Pharmacokinetic/Pharmacodynamic Modeling of Depot Testosterone Cypionate in Healthy Male Subjects
by: Youwei Bi, et al.
Published: (2018-04-01)

A methodological review on the pharmacokinetic/pharmacodynamic integration of antibacterial drugs
by: Hongjuan WANG, et al.
Published: (2022-02-01)

Food Bioactive Compounds and Their Interference in Drug Pharmacokinetic/Pharmacodynamic Profiles
by: Matteo Briguglio, et al.
Published: (2018-12-01)

Advance on synthesis, pharmacokinetics, and pharmacodynamics of the anti-epileptic drug: Levetiracetam
by: Wang Wei
Published: (2020-01-01)

Application of Pharmacokinetic-Pharmacodynamic Modeling in Drug Delivery: Development and Challenges
by: Huixi Zou, et al.
Published: (2020-07-01)

Study of GABA in healthy volunteers: pharmacokinetics and pharmacodynamics
by: Junfeng eLi, et al.
Published: (2015-11-01)

Concept and utility of population pharmacokinetic and pharmacokinetic/pharmacodynamic models in drug development and clinical practice
by: Roganović Maša, et al.
Published: (2021-01-01)

Development of a particle swarm optimization-backpropagation artificial neural network model and effects of age and gender on pharmacokinetics study of omeprazole enteric-coated tablets in Chinese population
by: Yichao Xu, et al.
Published: (2022-07-01)

The influence of dietary sodium content on the pharmacokinetics and pharmacodynamics of fimasartan
by: Gu N, et al.
Published: (2016-04-01)

Pharmacokinetics and Pharmacodynamics of Colistin Methanesulfonate in Healthy Chinese Subjects after Multi-Dose Regimen
by: Yaxin Fan, et al.
Published: (2022-06-01)

Single- and multiple-dose pharmacokinetics, pharmacodynamics, and safety of apixaban in healthy Chinese subjects [Corrigendum]
by: Cui Y, et al.
Published: (2014-03-01)

Valproate, divalproex, valpromide: Are the differences in indications justified?
by: Clément Delage, et al.
Published: (2023-02-01)

Combination therapy in cancer: effects of angiogenesis inhibitors on drug pharmacokinetics and pharmacodynamics
by: Ilaria Fuso Nerini, et al.
Published: (2016-06-01)

The Role of Organic Cation Transporters in the Pharmacokinetics, Pharmacodynamics and Drug–Drug Interactions of Tyrosine Kinase Inhibitors
by: Fangrui Xiu, et al.
Published: (2023-01-01)

Development and validation of a new LC–MS/MS method for the determination of mefatinib in human plasma and its first application in pharmacokinetic studies
by: Yichao Xu, et al.
Published: (2022-11-01)

Pharmacokinetics and pharmacodynamics of injectable dex-rabrazole for healthy people
by: YU Mingjie, et al.
Published: (2021-09-01)