Administration of troxerutin improves testicular function and structure in type-1 diabetic adult rats by reduction of apoptosis
Objective: The glucose-reducing effects of troxerutin was previously proven. This study was conducted to evaluate troxerutin effect on testicular structure and spermatozoid parameters in type-1 diabetic adult male rats. Materials and Methods: Fifty male Wistar rats were randomly classified into 5 gr...
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2019-06-01
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| Series: | Avicenna Journal of Phytomedicine |
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| Online Access: | http://ajp.mums.ac.ir/article_12741_42f5452102d9eef12a47ec3e38cece8a.pdf |
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| author | Afsaneh Qadiri Fariba Mirzaei Bavil Gholamreza Hamidian Zohreh Zavvari Oskuye Mahdi Ahmadi Hajar Oghbaei Keivan Mehri Amir Mansour Vatankhah Rana Keyhanmanesh |
| author_facet | Afsaneh Qadiri Fariba Mirzaei Bavil Gholamreza Hamidian Zohreh Zavvari Oskuye Mahdi Ahmadi Hajar Oghbaei Keivan Mehri Amir Mansour Vatankhah Rana Keyhanmanesh |
| author_sort | Afsaneh Qadiri |
| collection | DOAJ |
| description | Objective: The glucose-reducing effects of troxerutin was previously proven. This study was conducted to evaluate troxerutin effect on testicular structure and spermatozoid parameters in type-1 diabetic adult male rats. Materials and Methods: Fifty male Wistar rats were randomly classified into 5 groups as follows: control (C), troxerutin (T), diabetic (DM), troxerutin-treated DM (DT) and insulin-treated DM (DI). Testicular structure, apoptosis, lipid peroxidation and antioxidant activity, and spermatozoid parameters were assessed 4 weeks after initiation of the interventions. Results: The results revealed that diabetes caused testicular stereological changes and significantly increased blood glucose level, testicular MDA content and apoptosis but decreased insulin level, testicular GPX activity, and sperm parameters compared to controls (p Conclusion: Taken together, troxerutin, comparable to insulin, effectively improved DM-induced testicular dysfunction and sperm parameters in diabetic rats and these effects might be mediated through troxerutin’s anti-apoptotic effects. |
| first_indexed | 2024-12-22T02:19:41Z |
| format | Article |
| id | doaj.art-53c23684ab2c423e84c8fa0549e1c820 |
| institution | Directory Open Access Journal |
| issn | 2228-7930 2228-7949 |
| language | English |
| last_indexed | 2024-12-22T02:19:41Z |
| publishDate | 2019-06-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Avicenna Journal of Phytomedicine |
| spelling | doaj.art-53c23684ab2c423e84c8fa0549e1c8202022-12-21T18:42:10ZengMashhad University of Medical SciencesAvicenna Journal of Phytomedicine2228-79302228-79492019-06-019437438510.22038/ajp.2019.1274112741Administration of troxerutin improves testicular function and structure in type-1 diabetic adult rats by reduction of apoptosisAfsaneh Qadiri0Fariba Mirzaei Bavil1Gholamreza Hamidian2Zohreh Zavvari Oskuye3Mahdi Ahmadi4Hajar Oghbaei5Keivan Mehri6Amir Mansour Vatankhah7Rana Keyhanmanesh8Department of physiology, Faculty of medicine, Tabriz University of Medical Sciences, Tabriz, Iran.|Student research committee, Tabriz University of Medical Sciences, Tabriz, IranDrug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.Department of Basic Sciences, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran.Department of physiology, Faculty of medicine, Tabriz University of Medical Sciences, Tabriz, IranTuberculosis and Lung Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, IranDepartment of physiology, Faculty of medicine, Tabriz University of Medical Sciences, Tabriz, IranDepartment of physiology, Faculty of medicine, Tabriz University of Medical Sciences, Tabriz, IranDrug applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.Objective: The glucose-reducing effects of troxerutin was previously proven. This study was conducted to evaluate troxerutin effect on testicular structure and spermatozoid parameters in type-1 diabetic adult male rats. Materials and Methods: Fifty male Wistar rats were randomly classified into 5 groups as follows: control (C), troxerutin (T), diabetic (DM), troxerutin-treated DM (DT) and insulin-treated DM (DI). Testicular structure, apoptosis, lipid peroxidation and antioxidant activity, and spermatozoid parameters were assessed 4 weeks after initiation of the interventions. Results: The results revealed that diabetes caused testicular stereological changes and significantly increased blood glucose level, testicular MDA content and apoptosis but decreased insulin level, testicular GPX activity, and sperm parameters compared to controls (p Conclusion: Taken together, troxerutin, comparable to insulin, effectively improved DM-induced testicular dysfunction and sperm parameters in diabetic rats and these effects might be mediated through troxerutin’s anti-apoptotic effects.http://ajp.mums.ac.ir/article_12741_42f5452102d9eef12a47ec3e38cece8a.pdfDiabetesTroxerutinTestisApoposisStress oxidativeRat |
| spellingShingle | Afsaneh Qadiri Fariba Mirzaei Bavil Gholamreza Hamidian Zohreh Zavvari Oskuye Mahdi Ahmadi Hajar Oghbaei Keivan Mehri Amir Mansour Vatankhah Rana Keyhanmanesh Administration of troxerutin improves testicular function and structure in type-1 diabetic adult rats by reduction of apoptosis Avicenna Journal of Phytomedicine Diabetes Troxerutin Testis Apoposis Stress oxidative Rat |
| title | Administration of troxerutin improves testicular function and structure in type-1 diabetic adult rats by reduction of apoptosis |
| title_full | Administration of troxerutin improves testicular function and structure in type-1 diabetic adult rats by reduction of apoptosis |
| title_fullStr | Administration of troxerutin improves testicular function and structure in type-1 diabetic adult rats by reduction of apoptosis |
| title_full_unstemmed | Administration of troxerutin improves testicular function and structure in type-1 diabetic adult rats by reduction of apoptosis |
| title_short | Administration of troxerutin improves testicular function and structure in type-1 diabetic adult rats by reduction of apoptosis |
| title_sort | administration of troxerutin improves testicular function and structure in type 1 diabetic adult rats by reduction of apoptosis |
| topic | Diabetes Troxerutin Testis Apoposis Stress oxidative Rat |
| url | http://ajp.mums.ac.ir/article_12741_42f5452102d9eef12a47ec3e38cece8a.pdf |
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