Obstetric Results after Fertility-Sparing Management of Non-Epithelial Ovarian Cancer
Purpose: To assess the recurrence and birth rates among patients with non-epithelial ovarian cancer. Methods: The study included 146 patients with germ cell (GCT, n = 84) and sex cord-stromal tumors (SCST, n = 62), who underwent fertility-sparing surgery. Adjuvant chemotherapy was administered to 86...
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MDPI AG
2023-08-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/15/16/4170 |
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| author | Szymon Piątek Iwona Szymusik Piotr Sobiczewski Wojciech Michalski Magdalena Kowalska Mariusz Ołtarzewski Mariusz Bidziński |
| author_facet | Szymon Piątek Iwona Szymusik Piotr Sobiczewski Wojciech Michalski Magdalena Kowalska Mariusz Ołtarzewski Mariusz Bidziński |
| author_sort | Szymon Piątek |
| collection | DOAJ |
| description | Purpose: To assess the recurrence and birth rates among patients with non-epithelial ovarian cancer. Methods: The study included 146 patients with germ cell (GCT, n = 84) and sex cord-stromal tumors (SCST, n = 62), who underwent fertility-sparing surgery. Adjuvant chemotherapy was administered to 86 (58.9%) patients. Most cases (133 out of 146) were staged FIGO I. Results: The 5- and 10-year disease-free survival rates were 91% and 83%, respectively. The recurrence risk was not associated with tumor histology, stage or age. Twenty-four months after the treatment, the rate of recurrence was higher than the rate of childbearing. The childbearing rates kept rising after the treatment and exceeded the rate of recurrence after 2 years. The cumulative incidence rates of birth 36, 60 and 120 months after treatment were 13.24%, 20.75%, and 42.37%, respectively. Chemotherapy was not related to childbearing. The patients’ age was related to the chance of childbearing. Conclusions: The prognoses of GCT and SCST are similar. Close follow-ups along with contraception should be offered to women during the first two years after treatment due to the increased risk of recurrence. After this period, relapses are rare and women can safely become pregnant. |
| first_indexed | 2024-03-11T00:03:14Z |
| format | Article |
| id | doaj.art-53c338d8513648f4a8cc9377d0d6346d |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-11T00:03:14Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-53c338d8513648f4a8cc9377d0d6346d2023-11-19T00:34:20ZengMDPI AGCancers2072-66942023-08-011516417010.3390/cancers15164170Obstetric Results after Fertility-Sparing Management of Non-Epithelial Ovarian CancerSzymon Piątek0Iwona Szymusik1Piotr Sobiczewski2Wojciech Michalski3Magdalena Kowalska4Mariusz Ołtarzewski5Mariusz Bidziński6Department of Gynecologic Oncology, The Maria Sklodowska-Curie National Research Institute of Oncology, 02-781 Warsaw, PolandDepartment of Obstetrics, Perinatology and Neonatology, Center of Postgraduate Medical Education, 80 Ceglowska Street, 00-001 Warsaw, PolandDepartment of Gynecologic Oncology, The Maria Sklodowska-Curie National Research Institute of Oncology, 02-781 Warsaw, PolandDepartment of Gynecologic Oncology, The Maria Sklodowska-Curie National Research Institute of Oncology, 02-781 Warsaw, PolandDepartment of Gynecologic Oncology, The Maria Sklodowska-Curie National Research Institute of Oncology, 02-781 Warsaw, PolandInstitute of Mother and Child, 01-211 Warsaw, PolandDepartment of Gynecologic Oncology, The Maria Sklodowska-Curie National Research Institute of Oncology, 02-781 Warsaw, PolandPurpose: To assess the recurrence and birth rates among patients with non-epithelial ovarian cancer. Methods: The study included 146 patients with germ cell (GCT, n = 84) and sex cord-stromal tumors (SCST, n = 62), who underwent fertility-sparing surgery. Adjuvant chemotherapy was administered to 86 (58.9%) patients. Most cases (133 out of 146) were staged FIGO I. Results: The 5- and 10-year disease-free survival rates were 91% and 83%, respectively. The recurrence risk was not associated with tumor histology, stage or age. Twenty-four months after the treatment, the rate of recurrence was higher than the rate of childbearing. The childbearing rates kept rising after the treatment and exceeded the rate of recurrence after 2 years. The cumulative incidence rates of birth 36, 60 and 120 months after treatment were 13.24%, 20.75%, and 42.37%, respectively. Chemotherapy was not related to childbearing. The patients’ age was related to the chance of childbearing. Conclusions: The prognoses of GCT and SCST are similar. Close follow-ups along with contraception should be offered to women during the first two years after treatment due to the increased risk of recurrence. After this period, relapses are rare and women can safely become pregnant.https://www.mdpi.com/2072-6694/15/16/4170non-epithelial ovarian cancergerm cell tumorsex cord-stromal tumorfertility-sparing surgeryobstetric outcomebirth rate |
| spellingShingle | Szymon Piątek Iwona Szymusik Piotr Sobiczewski Wojciech Michalski Magdalena Kowalska Mariusz Ołtarzewski Mariusz Bidziński Obstetric Results after Fertility-Sparing Management of Non-Epithelial Ovarian Cancer Cancers non-epithelial ovarian cancer germ cell tumor sex cord-stromal tumor fertility-sparing surgery obstetric outcome birth rate |
| title | Obstetric Results after Fertility-Sparing Management of Non-Epithelial Ovarian Cancer |
| title_full | Obstetric Results after Fertility-Sparing Management of Non-Epithelial Ovarian Cancer |
| title_fullStr | Obstetric Results after Fertility-Sparing Management of Non-Epithelial Ovarian Cancer |
| title_full_unstemmed | Obstetric Results after Fertility-Sparing Management of Non-Epithelial Ovarian Cancer |
| title_short | Obstetric Results after Fertility-Sparing Management of Non-Epithelial Ovarian Cancer |
| title_sort | obstetric results after fertility sparing management of non epithelial ovarian cancer |
| topic | non-epithelial ovarian cancer germ cell tumor sex cord-stromal tumor fertility-sparing surgery obstetric outcome birth rate |
| url | https://www.mdpi.com/2072-6694/15/16/4170 |
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