Spatiotemporal Regulation of Rho GTPases in Neuronal Migration
Neuronal migration is essential for the orchestration of brain development and involves several contiguous steps: interkinetic nuclear movement (INM), multipolar−bipolar transition, locomotion, and translocation. Growing evidence suggests that Rho GTPases, including RhoA, Rac, Cdc42, and t...
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| Format: | Article |
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MDPI AG
2019-06-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/8/6/568 |
| _version_ | 1827884816518873088 |
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| author | Zhenyan Xu Yuewen Chen Yu Chen |
| author_facet | Zhenyan Xu Yuewen Chen Yu Chen |
| author_sort | Zhenyan Xu |
| collection | DOAJ |
| description | Neuronal migration is essential for the orchestration of brain development and involves several contiguous steps: interkinetic nuclear movement (INM), multipolar−bipolar transition, locomotion, and translocation. Growing evidence suggests that Rho GTPases, including RhoA, Rac, Cdc42, and the atypical Rnd members, play critical roles in neuronal migration by regulating both actin and microtubule cytoskeletal components. This review focuses on the spatiotemporal-specific regulation of Rho GTPases as well as their regulators and effectors in distinct steps during the neuronal migration process. Their roles in bridging extracellular signals and cytoskeletal dynamics to provide optimal structural support to the migrating neurons will also be discussed. |
| first_indexed | 2024-03-12T19:36:22Z |
| format | Article |
| id | doaj.art-53c7970349284bc3a1f3690f09e4230b |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-12T19:36:22Z |
| publishDate | 2019-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-53c7970349284bc3a1f3690f09e4230b2023-08-02T04:09:45ZengMDPI AGCells2073-44092019-06-018656810.3390/cells8060568cells8060568Spatiotemporal Regulation of Rho GTPases in Neuronal MigrationZhenyan Xu0Yuewen Chen1Yu Chen2The Brain Cognition and Brain Disease Institute, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions, Shenzhen 518055, Guangdong, ChinaThe Brain Cognition and Brain Disease Institute, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions, Shenzhen 518055, Guangdong, ChinaThe Brain Cognition and Brain Disease Institute, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions, Shenzhen 518055, Guangdong, ChinaNeuronal migration is essential for the orchestration of brain development and involves several contiguous steps: interkinetic nuclear movement (INM), multipolar−bipolar transition, locomotion, and translocation. Growing evidence suggests that Rho GTPases, including RhoA, Rac, Cdc42, and the atypical Rnd members, play critical roles in neuronal migration by regulating both actin and microtubule cytoskeletal components. This review focuses on the spatiotemporal-specific regulation of Rho GTPases as well as their regulators and effectors in distinct steps during the neuronal migration process. Their roles in bridging extracellular signals and cytoskeletal dynamics to provide optimal structural support to the migrating neurons will also be discussed.https://www.mdpi.com/2073-4409/8/6/568Rho GTPaseguanine nucleotide exchange factorGTPase-activating proteinneuronal migrationneuronal development |
| spellingShingle | Zhenyan Xu Yuewen Chen Yu Chen Spatiotemporal Regulation of Rho GTPases in Neuronal Migration Cells Rho GTPase guanine nucleotide exchange factor GTPase-activating protein neuronal migration neuronal development |
| title | Spatiotemporal Regulation of Rho GTPases in Neuronal Migration |
| title_full | Spatiotemporal Regulation of Rho GTPases in Neuronal Migration |
| title_fullStr | Spatiotemporal Regulation of Rho GTPases in Neuronal Migration |
| title_full_unstemmed | Spatiotemporal Regulation of Rho GTPases in Neuronal Migration |
| title_short | Spatiotemporal Regulation of Rho GTPases in Neuronal Migration |
| title_sort | spatiotemporal regulation of rho gtpases in neuronal migration |
| topic | Rho GTPase guanine nucleotide exchange factor GTPase-activating protein neuronal migration neuronal development |
| url | https://www.mdpi.com/2073-4409/8/6/568 |
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