Atopic dermatitis, systemic inflammation and subsequent dementia risk
Abstract Background Atopic dermatitis is a chronic inflammatory skin disease and inflammation has been implicated in development of other chronic diseases, but few studies have examined the relationship with dementia. Objectives This study examines associations of atopic dermatitis (AD) and systemic...
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Language: | English |
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Wiley
2023-12-01
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Series: | JEADV Clinical Practice |
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Online Access: | https://doi.org/10.1002/jvc2.249 |
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author | Snieguole Vingeliene Ayako Hiyoshi Michael Carlberg Miguel Garcia‐Argibay Marleen Lentjes Katja Fall Laura vonKobyletzki Scott Montgomery |
author_facet | Snieguole Vingeliene Ayako Hiyoshi Michael Carlberg Miguel Garcia‐Argibay Marleen Lentjes Katja Fall Laura vonKobyletzki Scott Montgomery |
author_sort | Snieguole Vingeliene |
collection | DOAJ |
description | Abstract Background Atopic dermatitis is a chronic inflammatory skin disease and inflammation has been implicated in development of other chronic diseases, but few studies have examined the relationship with dementia. Objectives This study examines associations of atopic dermatitis (AD) and systemic inflammation in adolescence measured using erythrocyte sedimentation rate (ESR), as well as AD diagnosed in adulthood, with dementia risk. Methods We used three Swedish register‐based cohorts. Cohort I (N = 795,680) comprised men, born in 1951–1968, who participated in the military conscription examinations with physician‐assessed AD and ESR; Cohort II (N = 1,757,600) included men and women, born in 1951–1968; and Cohort III (N = 3,988,783) included all individuals in Sweden, born in 1930–1968. We used Cox regression, estimating hazard ratios (HR), with the follow‐up from 50 years of age to dementia diagnosis, date of emigration, death, or 31 December 2018, whichever occurred first. Further, we used a sibling comparison design to adjust for unmeasured confounders shared among siblings. Results Cohort I: 1466 dementia events were accrued during follow‐up of 7.8 years, with a crude rate of 21.6 [95% confidence interval (CI): 20.6, 22.8] per 100,000 person‐years. Cohort II: 3549 dementia events were accrued during follow‐up of 7.4 years, with a crude rate of 23.7 (95% CI: 22.9, 24.5) per 100,000 person‐years. Cohort III: 120,303 dementia events were accrued during follow‐up of 23.7 years, with a crude rate of 180.3 (95% CI: 179.3, 181.3) per 100,000 person‐years. In multivariable analysis using Cohort I, there was no association between AD and dementia [HR 0.68 (95% CI 0.32, 1.43)], nor with moderate [HR 0.71 (95% CI: 0.46, 1.10)] or high [HR 1.23 (95% CI: 0.87, 1.75)] ESR. AD was not associated with dementia risk in Cohort II [HR 1.28 (0.97, 1.71)] or Cohort III [HR 1.01 (0.92, 1.11)]. Conclusions AD was not associated with dementia risk, neither was systemic inflammation measured by ESR in adolescence. |
first_indexed | 2024-03-09T10:45:23Z |
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id | doaj.art-53c7b3cfeaf441b88c150a9ac3ec62a6 |
institution | Directory Open Access Journal |
issn | 2768-6566 |
language | English |
last_indexed | 2024-03-09T10:45:23Z |
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publisher | Wiley |
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series | JEADV Clinical Practice |
spelling | doaj.art-53c7b3cfeaf441b88c150a9ac3ec62a62023-12-01T10:43:27ZengWileyJEADV Clinical Practice2768-65662023-12-012483984810.1002/jvc2.249Atopic dermatitis, systemic inflammation and subsequent dementia riskSnieguole Vingeliene0Ayako Hiyoshi1Michael Carlberg2Miguel Garcia‐Argibay3Marleen Lentjes4Katja Fall5Laura vonKobyletzki6Scott Montgomery7Clinical Epidemiology and Biostatistics, School of Medical Sciences, Faculty of Medicine and Health Örebro University Örebro SwedenClinical Epidemiology and Biostatistics, School of Medical Sciences, Faculty of Medicine and Health Örebro University Örebro SwedenClinical Epidemiology and Biostatistics, School of Medical Sciences, Faculty of Medicine and Health Örebro University Örebro SwedenClinical Epidemiology and Biostatistics, School of Medical Sciences, Faculty of Medicine and Health Örebro University Örebro SwedenClinical Epidemiology and Biostatistics, School of Medical Sciences, Faculty of Medicine and Health Örebro University Örebro SwedenClinical Epidemiology and Biostatistics, School of Medical Sciences, Faculty of Medicine and Health Örebro University Örebro SwedenClinical Epidemiology and Biostatistics, School of Medical Sciences, Faculty of Medicine and Health Örebro University Örebro SwedenClinical Epidemiology and Biostatistics, School of Medical Sciences, Faculty of Medicine and Health Örebro University Örebro SwedenAbstract Background Atopic dermatitis is a chronic inflammatory skin disease and inflammation has been implicated in development of other chronic diseases, but few studies have examined the relationship with dementia. Objectives This study examines associations of atopic dermatitis (AD) and systemic inflammation in adolescence measured using erythrocyte sedimentation rate (ESR), as well as AD diagnosed in adulthood, with dementia risk. Methods We used three Swedish register‐based cohorts. Cohort I (N = 795,680) comprised men, born in 1951–1968, who participated in the military conscription examinations with physician‐assessed AD and ESR; Cohort II (N = 1,757,600) included men and women, born in 1951–1968; and Cohort III (N = 3,988,783) included all individuals in Sweden, born in 1930–1968. We used Cox regression, estimating hazard ratios (HR), with the follow‐up from 50 years of age to dementia diagnosis, date of emigration, death, or 31 December 2018, whichever occurred first. Further, we used a sibling comparison design to adjust for unmeasured confounders shared among siblings. Results Cohort I: 1466 dementia events were accrued during follow‐up of 7.8 years, with a crude rate of 21.6 [95% confidence interval (CI): 20.6, 22.8] per 100,000 person‐years. Cohort II: 3549 dementia events were accrued during follow‐up of 7.4 years, with a crude rate of 23.7 (95% CI: 22.9, 24.5) per 100,000 person‐years. Cohort III: 120,303 dementia events were accrued during follow‐up of 23.7 years, with a crude rate of 180.3 (95% CI: 179.3, 181.3) per 100,000 person‐years. In multivariable analysis using Cohort I, there was no association between AD and dementia [HR 0.68 (95% CI 0.32, 1.43)], nor with moderate [HR 0.71 (95% CI: 0.46, 1.10)] or high [HR 1.23 (95% CI: 0.87, 1.75)] ESR. AD was not associated with dementia risk in Cohort II [HR 1.28 (0.97, 1.71)] or Cohort III [HR 1.01 (0.92, 1.11)]. Conclusions AD was not associated with dementia risk, neither was systemic inflammation measured by ESR in adolescence.https://doi.org/10.1002/jvc2.249atopic dermatitisdementiaerythrocyte sedimentation rate |
spellingShingle | Snieguole Vingeliene Ayako Hiyoshi Michael Carlberg Miguel Garcia‐Argibay Marleen Lentjes Katja Fall Laura vonKobyletzki Scott Montgomery Atopic dermatitis, systemic inflammation and subsequent dementia risk JEADV Clinical Practice atopic dermatitis dementia erythrocyte sedimentation rate |
title | Atopic dermatitis, systemic inflammation and subsequent dementia risk |
title_full | Atopic dermatitis, systemic inflammation and subsequent dementia risk |
title_fullStr | Atopic dermatitis, systemic inflammation and subsequent dementia risk |
title_full_unstemmed | Atopic dermatitis, systemic inflammation and subsequent dementia risk |
title_short | Atopic dermatitis, systemic inflammation and subsequent dementia risk |
title_sort | atopic dermatitis systemic inflammation and subsequent dementia risk |
topic | atopic dermatitis dementia erythrocyte sedimentation rate |
url | https://doi.org/10.1002/jvc2.249 |
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