Long-term stability of ready-to-use epinephrine 0.02 mg/mL injection solution in 50 mL glass vials

In adult intensive care patients, epinephrine is mostly administered by continuous injection with syringe pumps. The objective of this study was to investigate the physicochemical stability of pharmacy prepared ready-to-use epinephrine (E) 0.02 mg/mL injection solutions (total volume 50 mL) for assi...

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Main Authors: Heeb Rita Marina, Erdnüß Frank, Reichhold Julia, Krämer Irene
Format: Article
Language:English
Published: De Gruyter 2022-04-01
Series:Pharmaceutical Technology in Hospital Pharmacy
Subjects:
Online Access:https://doi.org/10.1515/pthp-2021-0015
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author Heeb Rita Marina
Erdnüß Frank
Reichhold Julia
Krämer Irene
author_facet Heeb Rita Marina
Erdnüß Frank
Reichhold Julia
Krämer Irene
author_sort Heeb Rita Marina
collection DOAJ
description In adult intensive care patients, epinephrine is mostly administered by continuous injection with syringe pumps. The objective of this study was to investigate the physicochemical stability of pharmacy prepared ready-to-use epinephrine (E) 0.02 mg/mL injection solutions (total volume 50 mL) for assigning shelf-life.
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spelling doaj.art-53c7f657a6924d679f96a71aa362c4f02022-12-22T02:17:25ZengDe GruyterPharmaceutical Technology in Hospital Pharmacy2365-24112365-242X2022-04-0171798910.1515/pthp-2021-0015Long-term stability of ready-to-use epinephrine 0.02 mg/mL injection solution in 50 mL glass vialsHeeb Rita Marina0Erdnüß Frank1Reichhold Julia2Krämer Irene3Department of Pharmacy, University Medical Center Mainz, Johannes Gutenberg-University, Langenbeckstraße 1, D-55131Mainz, GermanyDepartment of Pharmacy, University Medical Center Mainz, Johannes Gutenberg-University, Langenbeckstraße 1, D-55131Mainz, GermanyDepartment of Pharmacy, University Medical Center Mainz, Johannes Gutenberg-University, Langenbeckstraße 1, D-55131Mainz, GermanyDepartment of Pharmacy, University Medical Center Mainz, Johannes Gutenberg-University, Langenbeckstraße 1, D-55131Mainz, GermanyIn adult intensive care patients, epinephrine is mostly administered by continuous injection with syringe pumps. The objective of this study was to investigate the physicochemical stability of pharmacy prepared ready-to-use epinephrine (E) 0.02 mg/mL injection solutions (total volume 50 mL) for assigning shelf-life.https://doi.org/10.1515/pthp-2021-0015adrenaline ready-to-use productepinephrinephysicochemical stability
spellingShingle Heeb Rita Marina
Erdnüß Frank
Reichhold Julia
Krämer Irene
Long-term stability of ready-to-use epinephrine 0.02 mg/mL injection solution in 50 mL glass vials
Pharmaceutical Technology in Hospital Pharmacy
adrenaline ready-to-use product
epinephrine
physicochemical stability
title Long-term stability of ready-to-use epinephrine 0.02 mg/mL injection solution in 50 mL glass vials
title_full Long-term stability of ready-to-use epinephrine 0.02 mg/mL injection solution in 50 mL glass vials
title_fullStr Long-term stability of ready-to-use epinephrine 0.02 mg/mL injection solution in 50 mL glass vials
title_full_unstemmed Long-term stability of ready-to-use epinephrine 0.02 mg/mL injection solution in 50 mL glass vials
title_short Long-term stability of ready-to-use epinephrine 0.02 mg/mL injection solution in 50 mL glass vials
title_sort long term stability of ready to use epinephrine 0 02 mg ml injection solution in 50 ml glass vials
topic adrenaline ready-to-use product
epinephrine
physicochemical stability
url https://doi.org/10.1515/pthp-2021-0015
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