Analysis of the association between Epstein Barr virus infection and Hodgkin lymphoma
Epstein Barr virus plays an important role in the pathogenesis of Hodgkin lymphoma. However, the frequency of its association in Bangladeshi people has not been widely studied. The aim of this study was to determine the association of Epstein Barr virus association in Hodgkin Lymphoma through detec...
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| Format: | Article |
| Language: | English |
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Bangabandhu Sheikh Mujib Medical University
2023-02-01
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| Series: | Bangabandhu Sheikh Mujib Medical University Journal |
| Subjects: | |
| Online Access: | https://banglajol.info/index.php/BSMMUJ/article/view/64225 |
| _version_ | 1797861890350645248 |
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| author | Jasmine Akhter Jahan S M Rashed Ul Islam Md Shafikul Alam Tanim Tasnim Binte Ahmed Md Rabiul Alam Ferdousy Begum |
| author_facet | Jasmine Akhter Jahan S M Rashed Ul Islam Md Shafikul Alam Tanim Tasnim Binte Ahmed Md Rabiul Alam Ferdousy Begum |
| author_sort | Jasmine Akhter Jahan |
| collection | DOAJ |
| description |
Epstein Barr virus plays an important role in the pathogenesis of Hodgkin lymphoma. However, the frequency of its association in Bangladeshi people has not been widely studied. The aim of this study was to determine the association of Epstein Barr virus association in Hodgkin Lymphoma through detection of Latent Membrane Protein 1 by immunohistochemistry and serum Epstein Barr virus viral capsid antigen IgG antibody titer by serology. This was a cross-sectional study in purposively selected 45 histologically diagnosed cases of Hodgkin lymphoma at Bangabandhu Sheikh Mujib Medical University, Dhaka, during the period of March 2017 to December 2018. Latent membrane protein 1 was positive in 71.1% of cases of Hodgkin lymphoma. Among these positive cases, 96% of cases had significantly raised titer of serum Epstein Barr virus viral capsid antigen IgG antibody (P<0.0001 obtained by Fisher’s Exact test), which had a male predominance. Mixed cellularity classical Hodgkin lymphoma showed the highest positivity.
Bangabandhu Sheikh Mujib Medical University Journal 2022;15(4):32-36
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| first_indexed | 2024-04-09T22:11:40Z |
| format | Article |
| id | doaj.art-53c849fc9fbd45d4ad8e390c4bda627f |
| institution | Directory Open Access Journal |
| issn | 2074-2908 2224-7750 |
| language | English |
| last_indexed | 2024-04-09T22:11:40Z |
| publishDate | 2023-02-01 |
| publisher | Bangabandhu Sheikh Mujib Medical University |
| record_format | Article |
| series | Bangabandhu Sheikh Mujib Medical University Journal |
| spelling | doaj.art-53c849fc9fbd45d4ad8e390c4bda627f2023-03-23T09:58:44ZengBangabandhu Sheikh Mujib Medical UniversityBangabandhu Sheikh Mujib Medical University Journal2074-29082224-77502023-02-01154Analysis of the association between Epstein Barr virus infection and Hodgkin lymphomaJasmine Akhter Jahan0S M Rashed Ul Islam1Md Shafikul Alam Tanim2Tasnim Binte Ahmed3Md Rabiul Alam4Ferdousy Begum5Lecturer, Department of Pathology, Mugda Medical College, DhakaAssociate Professor, Department of Virology, Bangabandhu Sheikh Mujib Medical University (BSMMU), DhakaAssistant Professor, Department of Pathology, US Bangla Medical College and Hospital, Narayanganj.Lecturer, Department of Pathology, Mugda Medical College, Dhaka,Assistant Registrar, Department of Nephrology, National Institute of Kidney Diseases and Urology (NIKDU), DhakaProfessor and Chairman, Department of Pathology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka Epstein Barr virus plays an important role in the pathogenesis of Hodgkin lymphoma. However, the frequency of its association in Bangladeshi people has not been widely studied. The aim of this study was to determine the association of Epstein Barr virus association in Hodgkin Lymphoma through detection of Latent Membrane Protein 1 by immunohistochemistry and serum Epstein Barr virus viral capsid antigen IgG antibody titer by serology. This was a cross-sectional study in purposively selected 45 histologically diagnosed cases of Hodgkin lymphoma at Bangabandhu Sheikh Mujib Medical University, Dhaka, during the period of March 2017 to December 2018. Latent membrane protein 1 was positive in 71.1% of cases of Hodgkin lymphoma. Among these positive cases, 96% of cases had significantly raised titer of serum Epstein Barr virus viral capsid antigen IgG antibody (P<0.0001 obtained by Fisher’s Exact test), which had a male predominance. Mixed cellularity classical Hodgkin lymphoma showed the highest positivity. Bangabandhu Sheikh Mujib Medical University Journal 2022;15(4):32-36 https://banglajol.info/index.php/BSMMUJ/article/view/64225Epstein Barr virus, Hodgkin Lymphoma, Latent membrane protein 1, Viral capsid antigen IgG. |
| spellingShingle | Jasmine Akhter Jahan S M Rashed Ul Islam Md Shafikul Alam Tanim Tasnim Binte Ahmed Md Rabiul Alam Ferdousy Begum Analysis of the association between Epstein Barr virus infection and Hodgkin lymphoma Bangabandhu Sheikh Mujib Medical University Journal Epstein Barr virus, Hodgkin Lymphoma, Latent membrane protein 1, Viral capsid antigen IgG. |
| title | Analysis of the association between Epstein Barr virus infection and Hodgkin lymphoma |
| title_full | Analysis of the association between Epstein Barr virus infection and Hodgkin lymphoma |
| title_fullStr | Analysis of the association between Epstein Barr virus infection and Hodgkin lymphoma |
| title_full_unstemmed | Analysis of the association between Epstein Barr virus infection and Hodgkin lymphoma |
| title_short | Analysis of the association between Epstein Barr virus infection and Hodgkin lymphoma |
| title_sort | analysis of the association between epstein barr virus infection and hodgkin lymphoma |
| topic | Epstein Barr virus, Hodgkin Lymphoma, Latent membrane protein 1, Viral capsid antigen IgG. |
| url | https://banglajol.info/index.php/BSMMUJ/article/view/64225 |
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