Automatic and accurate ligand structure determination guided by cryo-electron microscopy maps
As cryo-EM becomes commonplace in drug discovery, tools for automating small molecule structure determination are needed. Here, authors show a map-guided ligand modeling approach to building ligand structures at resolutions common in cryo-EM.
Main Authors: | , , , , |
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Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2023-03-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-023-36732-5 |