The Capabilities of Amlodipine/Lisinopril Single-Pill Combination in the Treatment of Newly Diagnosed Arterial Hypertension in a Middle-Aged Patient (Case Report)
Arterial hypertension (AH) is one of the most significant modifiable risk factors that increase cardiovascular morbidity and mortality worldwide, including Russia. The complex of structural and functional changes in the heart that occurs during AH consists not only in the formation of left ventricul...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Столичная издательская компания
2020-05-01
|
| Series: | Рациональная фармакотерапия в кардиологии |
| Subjects: | |
| Online Access: | https://www.rpcardio.online/jour/article/view/2176 |
| _version_ | 1797232082975457280 |
|---|---|
| author | A. I. Kochetkov M. V. Lopukhina E. A. Kotaeva A. A. Kirichenko O. D. Ostroumova |
| author_facet | A. I. Kochetkov M. V. Lopukhina E. A. Kotaeva A. A. Kirichenko O. D. Ostroumova |
| author_sort | A. I. Kochetkov |
| collection | DOAJ |
| description | Arterial hypertension (AH) is one of the most significant modifiable risk factors that increase cardiovascular morbidity and mortality worldwide, including Russia. The complex of structural and functional changes in the heart that occurs during AH consists not only in the formation of left ventricular (LV) myocardial hypertrophy, but also in the myocardial stiffness increasing due to collagen formation and cardiomyocytes apoptosis. These abnormalities are substrate for diastolic function disturbances, electrical myocardial instability and ischemia. The article provides a clinical case of amlodipine/lisinopril single-pill combination (A/L SPC) use in real clinical practice in a patient with stage II grade 2 newly diagnosed AH and its effect on blood pressure and echocardiographic myocardial fibrosis markers, including speckle tracking parameters The high antihypertensive efficacy of A/L SPC, a favorable effect on blood pressure circadian rhythm, as well as pronounced target-organ protective properties, in particular the ability to reduce LV and left atrial stiffness, were demonstrated. So, we conclude that A/L SPC improve the elastic properties of the left heart. |
| first_indexed | 2024-03-08T14:00:59Z |
| format | Article |
| id | doaj.art-53c9787635d74b888c958e5482e036f6 |
| institution | Directory Open Access Journal |
| issn | 1819-6446 2225-3653 |
| language | English |
| last_indexed | 2024-04-24T15:54:38Z |
| publishDate | 2020-05-01 |
| publisher | Столичная издательская компания |
| record_format | Article |
| series | Рациональная фармакотерапия в кардиологии |
| spelling | doaj.art-53c9787635d74b888c958e5482e036f62024-04-01T07:43:39ZengСтоличная издательская компанияРациональная фармакотерапия в кардиологии1819-64462225-36532020-05-0116222123010.20996/1819-6446-2020-03-031732The Capabilities of Amlodipine/Lisinopril Single-Pill Combination in the Treatment of Newly Diagnosed Arterial Hypertension in a Middle-Aged Patient (Case Report)A. I. Kochetkov0M. V. Lopukhina1E. A. Kotaeva2A. A. Kirichenko3O. D. Ostroumova4Russian Medical Academy of Continuous Professional EducationE.O. Mukhin Municipal Clinical HospitalS.P. Botkin Municipal Clinical HospitalRussian Medical Academy of Continuous Professional EducationRussian Medical Academy of Continuous Professional Education; I.M. Sechenov First Moscow State Medical University (Sechenov University)Arterial hypertension (AH) is one of the most significant modifiable risk factors that increase cardiovascular morbidity and mortality worldwide, including Russia. The complex of structural and functional changes in the heart that occurs during AH consists not only in the formation of left ventricular (LV) myocardial hypertrophy, but also in the myocardial stiffness increasing due to collagen formation and cardiomyocytes apoptosis. These abnormalities are substrate for diastolic function disturbances, electrical myocardial instability and ischemia. The article provides a clinical case of amlodipine/lisinopril single-pill combination (A/L SPC) use in real clinical practice in a patient with stage II grade 2 newly diagnosed AH and its effect on blood pressure and echocardiographic myocardial fibrosis markers, including speckle tracking parameters The high antihypertensive efficacy of A/L SPC, a favorable effect on blood pressure circadian rhythm, as well as pronounced target-organ protective properties, in particular the ability to reduce LV and left atrial stiffness, were demonstrated. So, we conclude that A/L SPC improve the elastic properties of the left heart.https://www.rpcardio.online/jour/article/view/2176arterial hypertensionechocardiographyspeckle trackingambulatory blood pressure monitoringmyocardial stiffnesssingle-pill combinationsamlodipinelisinopril |
| spellingShingle | A. I. Kochetkov M. V. Lopukhina E. A. Kotaeva A. A. Kirichenko O. D. Ostroumova The Capabilities of Amlodipine/Lisinopril Single-Pill Combination in the Treatment of Newly Diagnosed Arterial Hypertension in a Middle-Aged Patient (Case Report) Рациональная фармакотерапия в кардиологии arterial hypertension echocardiography speckle tracking ambulatory blood pressure monitoring myocardial stiffness single-pill combinations amlodipine lisinopril |
| title | The Capabilities of Amlodipine/Lisinopril Single-Pill Combination in the Treatment of Newly Diagnosed Arterial Hypertension in a Middle-Aged Patient (Case Report) |
| title_full | The Capabilities of Amlodipine/Lisinopril Single-Pill Combination in the Treatment of Newly Diagnosed Arterial Hypertension in a Middle-Aged Patient (Case Report) |
| title_fullStr | The Capabilities of Amlodipine/Lisinopril Single-Pill Combination in the Treatment of Newly Diagnosed Arterial Hypertension in a Middle-Aged Patient (Case Report) |
| title_full_unstemmed | The Capabilities of Amlodipine/Lisinopril Single-Pill Combination in the Treatment of Newly Diagnosed Arterial Hypertension in a Middle-Aged Patient (Case Report) |
| title_short | The Capabilities of Amlodipine/Lisinopril Single-Pill Combination in the Treatment of Newly Diagnosed Arterial Hypertension in a Middle-Aged Patient (Case Report) |
| title_sort | capabilities of amlodipine lisinopril single pill combination in the treatment of newly diagnosed arterial hypertension in a middle aged patient case report |
| topic | arterial hypertension echocardiography speckle tracking ambulatory blood pressure monitoring myocardial stiffness single-pill combinations amlodipine lisinopril |
| url | https://www.rpcardio.online/jour/article/view/2176 |
| work_keys_str_mv | AT aikochetkov thecapabilitiesofamlodipinelisinoprilsinglepillcombinationinthetreatmentofnewlydiagnosedarterialhypertensioninamiddleagedpatientcasereport AT mvlopukhina thecapabilitiesofamlodipinelisinoprilsinglepillcombinationinthetreatmentofnewlydiagnosedarterialhypertensioninamiddleagedpatientcasereport AT eakotaeva thecapabilitiesofamlodipinelisinoprilsinglepillcombinationinthetreatmentofnewlydiagnosedarterialhypertensioninamiddleagedpatientcasereport AT aakirichenko thecapabilitiesofamlodipinelisinoprilsinglepillcombinationinthetreatmentofnewlydiagnosedarterialhypertensioninamiddleagedpatientcasereport AT odostroumova thecapabilitiesofamlodipinelisinoprilsinglepillcombinationinthetreatmentofnewlydiagnosedarterialhypertensioninamiddleagedpatientcasereport AT aikochetkov capabilitiesofamlodipinelisinoprilsinglepillcombinationinthetreatmentofnewlydiagnosedarterialhypertensioninamiddleagedpatientcasereport AT mvlopukhina capabilitiesofamlodipinelisinoprilsinglepillcombinationinthetreatmentofnewlydiagnosedarterialhypertensioninamiddleagedpatientcasereport AT eakotaeva capabilitiesofamlodipinelisinoprilsinglepillcombinationinthetreatmentofnewlydiagnosedarterialhypertensioninamiddleagedpatientcasereport AT aakirichenko capabilitiesofamlodipinelisinoprilsinglepillcombinationinthetreatmentofnewlydiagnosedarterialhypertensioninamiddleagedpatientcasereport AT odostroumova capabilitiesofamlodipinelisinoprilsinglepillcombinationinthetreatmentofnewlydiagnosedarterialhypertensioninamiddleagedpatientcasereport |