THE ROLE OF HEAT SHOCK PROTEIN (HSP) IN ORAL DISEASE
<p>Heat Shock Protein (HSP) is a molecular chaperone that prevents stress-induced aggregation of partially denatured proteins and promotes their return to native confirmation when the condition is favorable. As molecular chaperones, the HSP protect protein structure and activity, thereby preve...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Faculty of Dentistry, Universitas Indonesia
2015-06-01
|
| Series: | Journal of Dentistry Indonesia |
| Subjects: | |
| Online Access: | http://jdentistry.ui.ac.id/index.php/JDI/article/view/363 |
| _version_ | 1817983372392136704 |
|---|---|
| author | Theresia Indah Budhy Istiati K. Soehardjo |
| author_facet | Theresia Indah Budhy Istiati K. Soehardjo |
| author_sort | Theresia Indah Budhy |
| collection | DOAJ |
| description | <p>Heat Shock Protein (HSP) is a molecular chaperone that prevents stress-induced aggregation of partially denatured proteins and promotes their return to native confirmation when the condition is favorable. As molecular chaperones, the HSP protect protein structure and activity, thereby preventing disease, but they may contribute to cell malfunction if they are perturbed. Intracellular quantities and cellular localization of HSP was changed in response to anoxia/hypoxia, heat and oxidation, and in relation to pathological status. This review discusses the role of HSP in several human medical condition particularly in oral mucosa.</p> |
| first_indexed | 2024-04-13T23:32:22Z |
| format | Article |
| id | doaj.art-53ca1e88c7d7451ba9e8197b4f457217 |
| institution | Directory Open Access Journal |
| issn | 1693-9697 2355-4800 |
| language | English |
| last_indexed | 2024-04-13T23:32:22Z |
| publishDate | 2015-06-01 |
| publisher | Faculty of Dentistry, Universitas Indonesia |
| record_format | Article |
| series | Journal of Dentistry Indonesia |
| spelling | doaj.art-53ca1e88c7d7451ba9e8197b4f4572172022-12-22T02:24:51ZengFaculty of Dentistry, Universitas IndonesiaJournal of Dentistry Indonesia1693-96972355-48002015-06-0113310.14693/jdi.v13i3.363280THE ROLE OF HEAT SHOCK PROTEIN (HSP) IN ORAL DISEASETheresia Indah Budhy0Istiati K. Soehardjo1Department of Oral Biology, Faculty of Dentistry, Universitas Indonesia, Jakarta 10430Department of Oral Biology, Faculty of Dentistry, Universitas Indonesia, Jakarta 10430<p>Heat Shock Protein (HSP) is a molecular chaperone that prevents stress-induced aggregation of partially denatured proteins and promotes their return to native confirmation when the condition is favorable. As molecular chaperones, the HSP protect protein structure and activity, thereby preventing disease, but they may contribute to cell malfunction if they are perturbed. Intracellular quantities and cellular localization of HSP was changed in response to anoxia/hypoxia, heat and oxidation, and in relation to pathological status. This review discusses the role of HSP in several human medical condition particularly in oral mucosa.</p>http://jdentistry.ui.ac.id/index.php/JDI/article/view/363Heat shock proteinsoral mucosaoral disease |
| spellingShingle | Theresia Indah Budhy Istiati K. Soehardjo THE ROLE OF HEAT SHOCK PROTEIN (HSP) IN ORAL DISEASE Journal of Dentistry Indonesia Heat shock proteins oral mucosa oral disease |
| title | THE ROLE OF HEAT SHOCK PROTEIN (HSP) IN ORAL DISEASE |
| title_full | THE ROLE OF HEAT SHOCK PROTEIN (HSP) IN ORAL DISEASE |
| title_fullStr | THE ROLE OF HEAT SHOCK PROTEIN (HSP) IN ORAL DISEASE |
| title_full_unstemmed | THE ROLE OF HEAT SHOCK PROTEIN (HSP) IN ORAL DISEASE |
| title_short | THE ROLE OF HEAT SHOCK PROTEIN (HSP) IN ORAL DISEASE |
| title_sort | role of heat shock protein hsp in oral disease |
| topic | Heat shock proteins oral mucosa oral disease |
| url | http://jdentistry.ui.ac.id/index.php/JDI/article/view/363 |
| work_keys_str_mv | AT theresiaindahbudhy theroleofheatshockproteinhspinoraldisease AT istiatiksoehardjo theroleofheatshockproteinhspinoraldisease AT theresiaindahbudhy roleofheatshockproteinhspinoraldisease AT istiatiksoehardjo roleofheatshockproteinhspinoraldisease |