Recent advances in analysis of capsaicin and its effects on metabolic pathways by mass spectrometry
Capsaicin is the main food active component in Capsicum that has gained considerable attention due to its broad biological activities, including antioxidation, anti-inflammation, anti-tumor, weight regulation, cardiac protection, anti-calculi, and diurnal-circadian regulation. The potent biological...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-07-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2023.1227517/full |
| _version_ | 1797770328563253248 |
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| author | Zifang Peng Wenfen Zhang Wenfen Zhang Xu Zhang Jian Mao Jian Mao Qidong Zhang Qidong Zhang Wuduo Zhao Shusheng Zhang Shusheng Zhang Jianping Xie Jianping Xie |
| author_facet | Zifang Peng Wenfen Zhang Wenfen Zhang Xu Zhang Jian Mao Jian Mao Qidong Zhang Qidong Zhang Wuduo Zhao Shusheng Zhang Shusheng Zhang Jianping Xie Jianping Xie |
| author_sort | Zifang Peng |
| collection | DOAJ |
| description | Capsaicin is the main food active component in Capsicum that has gained considerable attention due to its broad biological activities, including antioxidation, anti-inflammation, anti-tumor, weight regulation, cardiac protection, anti-calculi, and diurnal-circadian regulation. The potent biological effects of capsaicin are intimately related to metabolic pathways such as lipid metabolism, energy metabolism, and antioxidant stress. Mass spectrometry (MS) has emerged as an effective tool for deciphering the mechanisms underlying capsaicin metabolism and its biological impacts. However, it remains challenging to accurately identify and quantify capsaicin and its self-metabolites in complex food and biological samples, and to integrate multi-omics data generated from MS. In this work, we summarized recent advances in the detection of capsaicin and its self-metabolites using MS and discussed the relevant MS-based studies of metabolic pathways. Furthermore, we discussed current issues and future directions in this field. In-depth studies of capsaicin metabolism and its physiological functions based on MS is anticipated to yield new insights and methods for preventing and treating a wide range of diseases. |
| first_indexed | 2024-03-12T21:21:42Z |
| format | Article |
| id | doaj.art-53ca7ea37f4f4251a8394e9bebea70ca |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-03-12T21:21:42Z |
| publishDate | 2023-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-53ca7ea37f4f4251a8394e9bebea70ca2023-07-28T17:10:43ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2023-07-011010.3389/fnut.2023.12275171227517Recent advances in analysis of capsaicin and its effects on metabolic pathways by mass spectrometryZifang Peng0Wenfen Zhang1Wenfen Zhang2Xu Zhang3Jian Mao4Jian Mao5Qidong Zhang6Qidong Zhang7Wuduo Zhao8Shusheng Zhang9Shusheng Zhang10Jianping Xie11Jianping Xie12College of Chemistry, Zhengzhou University, Zhengzhou, Henan, ChinaCollege of Chemistry, Zhengzhou University, Zhengzhou, Henan, ChinaZhengzhou Tobacco Research Institute of CNTC, Zhengzhou, Henan, ChinaSchool of Ecology and Environment, Zhengzhou University, Zhengzhou, Henan, ChinaZhengzhou Tobacco Research Institute of CNTC, Zhengzhou, Henan, ChinaFood Laboratory of Zhongyuan, Flavor Science Research Center of Zhengzhou University, Luohe, Henan, ChinaZhengzhou Tobacco Research Institute of CNTC, Zhengzhou, Henan, ChinaFood Laboratory of Zhongyuan, Flavor Science Research Center of Zhengzhou University, Luohe, Henan, ChinaCollege of Chemistry, Zhengzhou University, Zhengzhou, Henan, ChinaCollege of Chemistry, Zhengzhou University, Zhengzhou, Henan, ChinaFood Laboratory of Zhongyuan, Flavor Science Research Center of Zhengzhou University, Luohe, Henan, ChinaZhengzhou Tobacco Research Institute of CNTC, Zhengzhou, Henan, ChinaFood Laboratory of Zhongyuan, Flavor Science Research Center of Zhengzhou University, Luohe, Henan, ChinaCapsaicin is the main food active component in Capsicum that has gained considerable attention due to its broad biological activities, including antioxidation, anti-inflammation, anti-tumor, weight regulation, cardiac protection, anti-calculi, and diurnal-circadian regulation. The potent biological effects of capsaicin are intimately related to metabolic pathways such as lipid metabolism, energy metabolism, and antioxidant stress. Mass spectrometry (MS) has emerged as an effective tool for deciphering the mechanisms underlying capsaicin metabolism and its biological impacts. However, it remains challenging to accurately identify and quantify capsaicin and its self-metabolites in complex food and biological samples, and to integrate multi-omics data generated from MS. In this work, we summarized recent advances in the detection of capsaicin and its self-metabolites using MS and discussed the relevant MS-based studies of metabolic pathways. Furthermore, we discussed current issues and future directions in this field. In-depth studies of capsaicin metabolism and its physiological functions based on MS is anticipated to yield new insights and methods for preventing and treating a wide range of diseases.https://www.frontiersin.org/articles/10.3389/fnut.2023.1227517/fullcapsaicinmass spectrometryfood analysismetabolic pathwaysbiological activities |
| spellingShingle | Zifang Peng Wenfen Zhang Wenfen Zhang Xu Zhang Jian Mao Jian Mao Qidong Zhang Qidong Zhang Wuduo Zhao Shusheng Zhang Shusheng Zhang Jianping Xie Jianping Xie Recent advances in analysis of capsaicin and its effects on metabolic pathways by mass spectrometry Frontiers in Nutrition capsaicin mass spectrometry food analysis metabolic pathways biological activities |
| title | Recent advances in analysis of capsaicin and its effects on metabolic pathways by mass spectrometry |
| title_full | Recent advances in analysis of capsaicin and its effects on metabolic pathways by mass spectrometry |
| title_fullStr | Recent advances in analysis of capsaicin and its effects on metabolic pathways by mass spectrometry |
| title_full_unstemmed | Recent advances in analysis of capsaicin and its effects on metabolic pathways by mass spectrometry |
| title_short | Recent advances in analysis of capsaicin and its effects on metabolic pathways by mass spectrometry |
| title_sort | recent advances in analysis of capsaicin and its effects on metabolic pathways by mass spectrometry |
| topic | capsaicin mass spectrometry food analysis metabolic pathways biological activities |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2023.1227517/full |
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