ER, p53 and MIB-1 are significantly associated with malignant phyllodes tumor
Background: Phyllodes tumors (PT) are rare. We evaluated the expression status of ER, Bcl2, p53, and MIB-1 protein in these tumors. Methods: One hundred and ninety-three tumors were examined using immunohistochemistry on tissue microarray. Results: ERβ (p <0.001), and p53 (p=0.006) in the strom...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2012-12-01
|
| Series: | Biomedical Journal |
| Subjects: | |
| Online Access: | http://www.biomedj.org/article.asp?issn=2319-4170;year=2012;volume=35;issue=6;spage=486;epage=492;aulast=Munawer |
| _version_ | 1811186140902850560 |
|---|---|
| author | Nurhayati H Munawer Reena Md Zin Siti-Aishah Md Ali Rohaizak Muhammad Jasmi Ali Srijit Das |
| author_facet | Nurhayati H Munawer Reena Md Zin Siti-Aishah Md Ali Rohaizak Muhammad Jasmi Ali Srijit Das |
| author_sort | Nurhayati H Munawer |
| collection | DOAJ |
| description | Background: Phyllodes tumors (PT) are rare. We evaluated the expression status of ER, Bcl2, p53, and MIB-1 protein in these tumors.
Methods: One hundred and ninety-three tumors were examined using immunohistochemistry on tissue microarray.
Results: ERβ (p <0.001), and p53 (p=0.006) in the stromal component were associated with tumor size. p53 expression was significantly associated with both epithelial and stromal components of malignant PTs (p<0.05). In PT, the decreased expressions of p53 and MIB-1 were significantly different with positive Bcl2 protein expression in epithelial component (p=0.000). Besides, MIB-1 was also found to be associated with ERα and ERβ in stromal component (p=0.000).
Conclusion: The expression of p53 with tumor size and histological grade in PTs may increase risk for malignancy. |
| first_indexed | 2024-04-11T13:41:57Z |
| format | Article |
| id | doaj.art-53ccdaee512744079db0d9004c3987d9 |
| institution | Directory Open Access Journal |
| issn | 2319-4170 2320-2890 |
| language | English |
| last_indexed | 2024-04-11T13:41:57Z |
| publishDate | 2012-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedical Journal |
| spelling | doaj.art-53ccdaee512744079db0d9004c3987d92022-12-22T04:21:14ZengElsevierBiomedical Journal2319-41702320-28902012-12-0135648649210.4103/2319-4170.104414ER, p53 and MIB-1 are significantly associated with malignant phyllodes tumorNurhayati H Munawer0 Reena Md Zin1 Siti-Aishah Md Ali2 Rohaizak Muhammad3 Jasmi Ali4 Srijit Das5Department of Pathology, Faculty of Medicine, University Kebangsaan Malaysia Medical Centre, Kuala Lumpur, MalaysiaDepartment of Pathology, Faculty of Medicine, University Kebangsaan Malaysia Medical Centre, Kuala Lumpur, MalaysiaDepartment of Pathology, Faculty of Medicine, University Kebangsaan Malaysia Medical Centre, Kuala Lumpur, MalaysiaDepartment of Surgery, Faculty of Medicine, University Kebangsaan Malaysia Medical Centre, Kuala Lumpur, MalaysiaDepartment of Surgery, Faculty of Medicine, University Kebangsaan Malaysia Medical Centre, Kuala Lumpur, MalaysiaDepartment of Anatomy, Faculty of Medicine, University Kebangsaan Malaysia Medical Centre, Kuala Lumpur, MalaysiaBackground: Phyllodes tumors (PT) are rare. We evaluated the expression status of ER, Bcl2, p53, and MIB-1 protein in these tumors. Methods: One hundred and ninety-three tumors were examined using immunohistochemistry on tissue microarray. Results: ERβ (p <0.001), and p53 (p=0.006) in the stromal component were associated with tumor size. p53 expression was significantly associated with both epithelial and stromal components of malignant PTs (p<0.05). In PT, the decreased expressions of p53 and MIB-1 were significantly different with positive Bcl2 protein expression in epithelial component (p=0.000). Besides, MIB-1 was also found to be associated with ERα and ERβ in stromal component (p=0.000). Conclusion: The expression of p53 with tumor size and histological grade in PTs may increase risk for malignancy.http://www.biomedj.org/article.asp?issn=2319-4170;year=2012;volume=35;issue=6;spage=486;epage=492;aulast=Munawerestrogen receptorfibroadenomaimmunohistochemistryMIB-1 proteinphyllodes tu-morp53 antigen |
| spellingShingle | Nurhayati H Munawer Reena Md Zin Siti-Aishah Md Ali Rohaizak Muhammad Jasmi Ali Srijit Das ER, p53 and MIB-1 are significantly associated with malignant phyllodes tumor Biomedical Journal estrogen receptor fibroadenoma immunohistochemistry MIB-1 protein phyllodes tu-mor p53 antigen |
| title | ER, p53 and MIB-1 are significantly associated with malignant phyllodes tumor |
| title_full | ER, p53 and MIB-1 are significantly associated with malignant phyllodes tumor |
| title_fullStr | ER, p53 and MIB-1 are significantly associated with malignant phyllodes tumor |
| title_full_unstemmed | ER, p53 and MIB-1 are significantly associated with malignant phyllodes tumor |
| title_short | ER, p53 and MIB-1 are significantly associated with malignant phyllodes tumor |
| title_sort | er p53 and mib 1 are significantly associated with malignant phyllodes tumor |
| topic | estrogen receptor fibroadenoma immunohistochemistry MIB-1 protein phyllodes tu-mor p53 antigen |
| url | http://www.biomedj.org/article.asp?issn=2319-4170;year=2012;volume=35;issue=6;spage=486;epage=492;aulast=Munawer |
| work_keys_str_mv | AT nurhayatihmunawer erp53andmib1aresignificantlyassociatedwithmalignantphyllodestumor AT reenamdzin erp53andmib1aresignificantlyassociatedwithmalignantphyllodestumor AT sitiaishahmdali erp53andmib1aresignificantlyassociatedwithmalignantphyllodestumor AT rohaizakmuhammad erp53andmib1aresignificantlyassociatedwithmalignantphyllodestumor AT jasmiali erp53andmib1aresignificantlyassociatedwithmalignantphyllodestumor AT srijitdas erp53andmib1aresignificantlyassociatedwithmalignantphyllodestumor |