New Hydrazones Bearing Thiazole Scaffold: Synthesis, Characterization, Antimicrobial, and Antioxidant Investigation
New series of hydrazones 5–18 were synthesized, in good yields, by reacting 4-methyl-2-(4-(trifluoromethyl)phenyl)thiazole-5-carbohydrazide with differently substituted benzaldehyde. The resulting compounds were characterized via elemental analysis, physico-chemical and spectral data. An antimicro...
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| Format: | Article |
| Language: | English |
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MDPI AG
2015-09-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/20/9/17325 |
| _version_ | 1811269072646569984 |
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| author | Cristina Nastasă Brîndușa Tiperciuc Mihaela Duma Daniela Benedec Ovidiu Oniga |
| author_facet | Cristina Nastasă Brîndușa Tiperciuc Mihaela Duma Daniela Benedec Ovidiu Oniga |
| author_sort | Cristina Nastasă |
| collection | DOAJ |
| description | New series of hydrazones 5–18 were synthesized, in good yields, by reacting 4-methyl-2-(4-(trifluoromethyl)phenyl)thiazole-5-carbohydrazide with differently substituted benzaldehyde. The resulting compounds were characterized via elemental analysis, physico-chemical and spectral data. An antimicrobial screening was done, using Gram (+), Gram (−) bacteria and one fungal strain. Tested molecules displayed moderate-to-good growth inhibition activity. 2,2-Diphenyl-1-picrylhydrazide assay was used to test the antioxidant properties of the compounds. Monohydroxy (14–16), para-fluorine (13) and 2,4-dichlorine (17) derivatives exhibited better free-radical scavenging ability than the other investigated molecules. |
| first_indexed | 2024-04-12T21:34:25Z |
| format | Article |
| id | doaj.art-53cdafb5d5e9490d961ceec89726e776 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-04-12T21:34:25Z |
| publishDate | 2015-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-53cdafb5d5e9490d961ceec89726e7762022-12-22T03:15:56ZengMDPI AGMolecules1420-30492015-09-01209173251733810.3390/molecules200917325molecules200917325New Hydrazones Bearing Thiazole Scaffold: Synthesis, Characterization, Antimicrobial, and Antioxidant InvestigationCristina Nastasă0Brîndușa Tiperciuc1Mihaela Duma2Daniela Benedec3Ovidiu Oniga4Department of Pharmaceutical Chemistry, "Iuliu Hațieganu" University of Medicine and Pharmacy 41 Victor Babeș Street, RO-400012 Cluj-Napoca, RomaniaDepartment of Pharmaceutical Chemistry, "Iuliu Hațieganu" University of Medicine and Pharmacy 41 Victor Babeș Street, RO-400012 Cluj-Napoca, RomaniaState Veterinary Laboratory for Animal Health and Safety, 1 Piața Mărăști Street, 400609 Cluj-Napoca, RomaniaDepartment of Pharmacognosy, "Iuliu Hațieganu" University of Medicine and Pharmacy, 12 Ion Creangă Street, RO-400010 Cluj-Napoca, RomaniaDepartment of Pharmaceutical Chemistry, "Iuliu Hațieganu" University of Medicine and Pharmacy 41 Victor Babeș Street, RO-400012 Cluj-Napoca, RomaniaNew series of hydrazones 5–18 were synthesized, in good yields, by reacting 4-methyl-2-(4-(trifluoromethyl)phenyl)thiazole-5-carbohydrazide with differently substituted benzaldehyde. The resulting compounds were characterized via elemental analysis, physico-chemical and spectral data. An antimicrobial screening was done, using Gram (+), Gram (−) bacteria and one fungal strain. Tested molecules displayed moderate-to-good growth inhibition activity. 2,2-Diphenyl-1-picrylhydrazide assay was used to test the antioxidant properties of the compounds. Monohydroxy (14–16), para-fluorine (13) and 2,4-dichlorine (17) derivatives exhibited better free-radical scavenging ability than the other investigated molecules.http://www.mdpi.com/1420-3049/20/9/17325thiazolehydrazideacyl-hydrazoneantibacterialantifungalantioxidant |
| spellingShingle | Cristina Nastasă Brîndușa Tiperciuc Mihaela Duma Daniela Benedec Ovidiu Oniga New Hydrazones Bearing Thiazole Scaffold: Synthesis, Characterization, Antimicrobial, and Antioxidant Investigation Molecules thiazole hydrazide acyl-hydrazone antibacterial antifungal antioxidant |
| title | New Hydrazones Bearing Thiazole Scaffold: Synthesis, Characterization, Antimicrobial, and Antioxidant Investigation |
| title_full | New Hydrazones Bearing Thiazole Scaffold: Synthesis, Characterization, Antimicrobial, and Antioxidant Investigation |
| title_fullStr | New Hydrazones Bearing Thiazole Scaffold: Synthesis, Characterization, Antimicrobial, and Antioxidant Investigation |
| title_full_unstemmed | New Hydrazones Bearing Thiazole Scaffold: Synthesis, Characterization, Antimicrobial, and Antioxidant Investigation |
| title_short | New Hydrazones Bearing Thiazole Scaffold: Synthesis, Characterization, Antimicrobial, and Antioxidant Investigation |
| title_sort | new hydrazones bearing thiazole scaffold synthesis characterization antimicrobial and antioxidant investigation |
| topic | thiazole hydrazide acyl-hydrazone antibacterial antifungal antioxidant |
| url | http://www.mdpi.com/1420-3049/20/9/17325 |
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