Ductal Dilatation of ≥5 mm in Intraductal Papillary Mucinous Neoplasm Should Trigger the Consideration for Pancreatectomy: A Meta-Analysis and Systematic Review of Resected Cases
Intraductal papillary mucinous neoplasms (IPMN) are common but difficult to manage since accurate tools for diagnosing malignancy are unavailable. This study tests the diagnostic value of the main pancreatic duct (MPD) diameter for detecting IPMN malignancy using a meta-analysis of published data of...
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MDPI AG
2021-04-01
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Series: | Cancers |
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Online Access: | https://www.mdpi.com/2072-6694/13/9/2031 |
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author | Y.H. Andrew Wu Atsushi Oba Laurel Beaty Kathryn L. Colborn Salvador Rodriguez Franco Ben Harnke Cheryl Meguid Daniel Negrini Roberto Valente Steven Ahrendt Richard D. Schulick Marco Del Chiaro |
author_facet | Y.H. Andrew Wu Atsushi Oba Laurel Beaty Kathryn L. Colborn Salvador Rodriguez Franco Ben Harnke Cheryl Meguid Daniel Negrini Roberto Valente Steven Ahrendt Richard D. Schulick Marco Del Chiaro |
author_sort | Y.H. Andrew Wu |
collection | DOAJ |
description | Intraductal papillary mucinous neoplasms (IPMN) are common but difficult to manage since accurate tools for diagnosing malignancy are unavailable. This study tests the diagnostic value of the main pancreatic duct (MPD) diameter for detecting IPMN malignancy using a meta-analysis of published data of resected IPMNs. Collected from a comprehensive literature search, the articles included in this analysis must report malignancy cases (high-grade dysplasia (HGD) and invasive carcinoma (IC)) and MPD diameter so that two MPD cut-offs could be created. The sensitivity, specificity, and odds ratios of the two cutoffs for predicting malignancy were calculated. A review of 1493 articles yielded 20 retrospective studies with 3982 resected cases. A cutoff of ≥5 mm is more sensitive than the ≥10 mm cutoff and has pooled sensitivity of 72.20% and 75.60% for classification of HGD and IC, respectively. Both MPD cutoffs of ≥5 mm and ≥10 mm were associated with malignancy (OR = 4.36 (95% CI: 2.82, 6.75) vs. OR = 3.18 (95% CI: 2.25, 4.49), respectively). The odds of HGD and IC for patients with MPD ≥5 mm were 5.66 (95% CI: 3.02, 10.62) and 7.40 (95% CI: 4.95, 11.06), respectively. OR of HGD and IC for MPD ≥10 mm cutoff were 4.36 (95% CI: 3.20, 5.93) and 4.75 (95% CI: 2.39, 9.45), respectively. IPMN with MPD of >5 mm could very likely be malignant. In selected IPMN patients, pancreatectomy should be considered when MPD is >5 mm. |
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language | English |
last_indexed | 2024-03-10T12:03:43Z |
publishDate | 2021-04-01 |
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series | Cancers |
spelling | doaj.art-53cde2429a734ddbaabf5491caf4a0682023-11-21T16:44:43ZengMDPI AGCancers2072-66942021-04-01139203110.3390/cancers13092031Ductal Dilatation of ≥5 mm in Intraductal Papillary Mucinous Neoplasm Should Trigger the Consideration for Pancreatectomy: A Meta-Analysis and Systematic Review of Resected CasesY.H. Andrew Wu0Atsushi Oba1Laurel Beaty2Kathryn L. Colborn3Salvador Rodriguez Franco4Ben Harnke5Cheryl Meguid6Daniel Negrini7Roberto Valente8Steven Ahrendt9Richard D. Schulick10Marco Del Chiaro11Division of Surgical Oncology, Department of Surgery, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USADivision of Surgical Oncology, Department of Surgery, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USADivision of Surgical Oncology, Department of Surgery, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USADivision of Surgical Oncology, Department of Surgery, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USADivision of Surgical Oncology, Department of Surgery, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USAStrauss Health Sciences Library, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USADivision of Surgical Oncology, Department of Surgery, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USADivision of Surgical Oncology, Department of Surgery, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USADivision of Surgical Oncology, Department of Surgery, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USADivision of Surgical Oncology, Department of Surgery, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USADivision of Surgical Oncology, Department of Surgery, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USADivision of Surgical Oncology, Department of Surgery, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USAIntraductal papillary mucinous neoplasms (IPMN) are common but difficult to manage since accurate tools for diagnosing malignancy are unavailable. This study tests the diagnostic value of the main pancreatic duct (MPD) diameter for detecting IPMN malignancy using a meta-analysis of published data of resected IPMNs. Collected from a comprehensive literature search, the articles included in this analysis must report malignancy cases (high-grade dysplasia (HGD) and invasive carcinoma (IC)) and MPD diameter so that two MPD cut-offs could be created. The sensitivity, specificity, and odds ratios of the two cutoffs for predicting malignancy were calculated. A review of 1493 articles yielded 20 retrospective studies with 3982 resected cases. A cutoff of ≥5 mm is more sensitive than the ≥10 mm cutoff and has pooled sensitivity of 72.20% and 75.60% for classification of HGD and IC, respectively. Both MPD cutoffs of ≥5 mm and ≥10 mm were associated with malignancy (OR = 4.36 (95% CI: 2.82, 6.75) vs. OR = 3.18 (95% CI: 2.25, 4.49), respectively). The odds of HGD and IC for patients with MPD ≥5 mm were 5.66 (95% CI: 3.02, 10.62) and 7.40 (95% CI: 4.95, 11.06), respectively. OR of HGD and IC for MPD ≥10 mm cutoff were 4.36 (95% CI: 3.20, 5.93) and 4.75 (95% CI: 2.39, 9.45), respectively. IPMN with MPD of >5 mm could very likely be malignant. In selected IPMN patients, pancreatectomy should be considered when MPD is >5 mm.https://www.mdpi.com/2072-6694/13/9/2031pancreatic main duct dilatationintraductal papillary mucinous neoplasmhigh grade dysplasiainvasive carcinomapancreatic cystic neoplasmpancreatic cancer |
spellingShingle | Y.H. Andrew Wu Atsushi Oba Laurel Beaty Kathryn L. Colborn Salvador Rodriguez Franco Ben Harnke Cheryl Meguid Daniel Negrini Roberto Valente Steven Ahrendt Richard D. Schulick Marco Del Chiaro Ductal Dilatation of ≥5 mm in Intraductal Papillary Mucinous Neoplasm Should Trigger the Consideration for Pancreatectomy: A Meta-Analysis and Systematic Review of Resected Cases Cancers pancreatic main duct dilatation intraductal papillary mucinous neoplasm high grade dysplasia invasive carcinoma pancreatic cystic neoplasm pancreatic cancer |
title | Ductal Dilatation of ≥5 mm in Intraductal Papillary Mucinous Neoplasm Should Trigger the Consideration for Pancreatectomy: A Meta-Analysis and Systematic Review of Resected Cases |
title_full | Ductal Dilatation of ≥5 mm in Intraductal Papillary Mucinous Neoplasm Should Trigger the Consideration for Pancreatectomy: A Meta-Analysis and Systematic Review of Resected Cases |
title_fullStr | Ductal Dilatation of ≥5 mm in Intraductal Papillary Mucinous Neoplasm Should Trigger the Consideration for Pancreatectomy: A Meta-Analysis and Systematic Review of Resected Cases |
title_full_unstemmed | Ductal Dilatation of ≥5 mm in Intraductal Papillary Mucinous Neoplasm Should Trigger the Consideration for Pancreatectomy: A Meta-Analysis and Systematic Review of Resected Cases |
title_short | Ductal Dilatation of ≥5 mm in Intraductal Papillary Mucinous Neoplasm Should Trigger the Consideration for Pancreatectomy: A Meta-Analysis and Systematic Review of Resected Cases |
title_sort | ductal dilatation of ≥5 mm in intraductal papillary mucinous neoplasm should trigger the consideration for pancreatectomy a meta analysis and systematic review of resected cases |
topic | pancreatic main duct dilatation intraductal papillary mucinous neoplasm high grade dysplasia invasive carcinoma pancreatic cystic neoplasm pancreatic cancer |
url | https://www.mdpi.com/2072-6694/13/9/2031 |
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