Single Stem Cell Imaging and Analysis Reveals Telomere Length Differences in Diseased Human and Mouse Skeletal Muscles

Single Stem Cell Imaging and Analysis Reveals Telomere Length Differences in Diseased Human and Mouse Skeletal Muscles

Muscle stem cells (MuSCs) contribute to muscle regeneration following injury. In many muscle disorders, the repeated cycles of damage and repair lead to stem cell dysfunction. While telomere attrition may contribute to aberrant stem cell functions, methods to accurately measure telomere length in st...

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Bibliographic Details
Main Authors: Elisia D. Tichy, David K. Sidibe, Matthew T. Tierney, Michael J. Stec, Maryam Sharifi-Sanjani, Harish Hosalkar, Scott Mubarak, F. Brad Johnson, Alessandra Sacco, Foteini Mourkioti
Format: Article
Language:English
Published: Elsevier 2017-10-01
Series:Stem Cell Reports
Subjects:
muscle stem cell
satellite cell
telomeres
MuQ-FISH
FISH
fluorescence in situ hybridization
fluorescence-activated cell sorting
Duchenne muscular dystrophy
DMD
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671117303600

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http://www.sciencedirect.com/science/article/pii/S2213671117303600

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