Novel Therapeutic Targets for Hypoxia-Related Cardiovascular Diseases: The Role of HIF-1
Insufficient oxygen availability (hypoxia) is a precursor to numerous cardiovascular diseases, including atherosclerosis, pulmonary hypertension, and heart failure. The main site of hypoxic injury in the human body is the mitochondria, where oxygen acts as the final electron acceptor in the process...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-07-01
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| Series: | Frontiers in Physiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fphys.2020.00774/full |
| _version_ | 1818842528827310080 |
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| author | Minxuan Liu Gina Galli Yilin Wang Qiru Fan Qiru Fan Zhenzhong Wang Xin Wang Wei Xiao |
| author_facet | Minxuan Liu Gina Galli Yilin Wang Qiru Fan Qiru Fan Zhenzhong Wang Xin Wang Wei Xiao |
| author_sort | Minxuan Liu |
| collection | DOAJ |
| description | Insufficient oxygen availability (hypoxia) is a precursor to numerous cardiovascular diseases, including atherosclerosis, pulmonary hypertension, and heart failure. The main site of hypoxic injury in the human body is the mitochondria, where oxygen acts as the final electron acceptor in the process of oxidative phosphorylation. Hypoxia-inducible factor (HIF) is activated in hypoxic conditions and acts as an important modulator of diverse target genes in the human body. The downstream genes of HIF include vital modulators of cardiovascular-related signaling pathways. Therefore, it is hypothesized that HIF represents a potential therapeutic target for the treatment and prevention of cardiovascular diseases. In this short review, we introduce the pathophysiology of hypoxic injury in cardiovascular disease, and we conclude from convincing evidence that HIF can modulate relevant cardioprotective signaling pathways. |
| first_indexed | 2024-12-19T04:43:25Z |
| format | Article |
| id | doaj.art-53d4901fd79f4c899eeda373153c5f3b |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-19T04:43:25Z |
| publishDate | 2020-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-53d4901fd79f4c899eeda373153c5f3b2022-12-21T20:35:32ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2020-07-011110.3389/fphys.2020.00774538341Novel Therapeutic Targets for Hypoxia-Related Cardiovascular Diseases: The Role of HIF-1Minxuan Liu0Gina Galli1Yilin Wang2Qiru Fan3Qiru Fan4Zhenzhong Wang5Xin Wang6Wei Xiao7State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang, ChinaFaculty of Life Sciences, The University of Manchester, Manchester, United KingdomPharmaceutical Sciences, University of Maryland, Baltimore, Baltimore, MD, United StatesState Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang, ChinaLife Science and Technology, China Pharmaceutical University, Nanjing, ChinaState Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang, ChinaFaculty of Life Sciences, The University of Manchester, Manchester, United KingdomState Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang, ChinaInsufficient oxygen availability (hypoxia) is a precursor to numerous cardiovascular diseases, including atherosclerosis, pulmonary hypertension, and heart failure. The main site of hypoxic injury in the human body is the mitochondria, where oxygen acts as the final electron acceptor in the process of oxidative phosphorylation. Hypoxia-inducible factor (HIF) is activated in hypoxic conditions and acts as an important modulator of diverse target genes in the human body. The downstream genes of HIF include vital modulators of cardiovascular-related signaling pathways. Therefore, it is hypothesized that HIF represents a potential therapeutic target for the treatment and prevention of cardiovascular diseases. In this short review, we introduce the pathophysiology of hypoxic injury in cardiovascular disease, and we conclude from convincing evidence that HIF can modulate relevant cardioprotective signaling pathways.https://www.frontiersin.org/article/10.3389/fphys.2020.00774/fullhypoxiacardiovascular diseasetherapeutic targetHIFmyocardial infarctionatherosclerosis |
| spellingShingle | Minxuan Liu Gina Galli Yilin Wang Qiru Fan Qiru Fan Zhenzhong Wang Xin Wang Wei Xiao Novel Therapeutic Targets for Hypoxia-Related Cardiovascular Diseases: The Role of HIF-1 Frontiers in Physiology hypoxia cardiovascular disease therapeutic target HIF myocardial infarction atherosclerosis |
| title | Novel Therapeutic Targets for Hypoxia-Related Cardiovascular Diseases: The Role of HIF-1 |
| title_full | Novel Therapeutic Targets for Hypoxia-Related Cardiovascular Diseases: The Role of HIF-1 |
| title_fullStr | Novel Therapeutic Targets for Hypoxia-Related Cardiovascular Diseases: The Role of HIF-1 |
| title_full_unstemmed | Novel Therapeutic Targets for Hypoxia-Related Cardiovascular Diseases: The Role of HIF-1 |
| title_short | Novel Therapeutic Targets for Hypoxia-Related Cardiovascular Diseases: The Role of HIF-1 |
| title_sort | novel therapeutic targets for hypoxia related cardiovascular diseases the role of hif 1 |
| topic | hypoxia cardiovascular disease therapeutic target HIF myocardial infarction atherosclerosis |
| url | https://www.frontiersin.org/article/10.3389/fphys.2020.00774/full |
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