IL-21 impairs pro-inflammatory activity of M1-like macrophages exerting anti-inflammatory effects on rheumatoid arthritis

IL-21 impairs pro-inflammatory activity of M1-like macrophages exerting anti-inflammatory effects on rheumatoid arthritis

Objective：Macrophages are the main source of inflammatory mediators and play important roles in the pathogenesis of rheumatoid arthritis (RA). Interleukin-21 (IL-21) regulates both innate and adaptive immune responses and exerts major effects on inflammatory responses that promote the development of...

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Bibliographic Details
Main Authors: Leilei Jian, Changhong Li, Xinyu Wang, Lin Sun, Zhenzhen Ma, Jinxia Zhao
Format: Article
Language:English
Published: Taylor & Francis Group 2022-02-01
Series:Autoimmunity
Subjects:
interleukin-21
rheumatoid arthritis
cytokine production
macrophage polarisation
erk1/2 signalling activation
Online Access:http://dx.doi.org/10.1080/08916934.2021.2007374

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