Speckle tracking echocardiography-derived left ventricular global longitudinal strain in ex-thalassaemics.
<h4>Aims</h4>Long term survivors of haematopoietic stem cell transplantation (HSCT) for β-thalassemia major are designated "ex-thalassaemics". Whether ex-thalassaemics continue to harbour residual myocardial dysfunction and thereby stand the risk of heart failure-related morbid...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2023-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0293452&type=printable |
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| author | Amal Paul Uday Kulkarni Bijesh Yadav Fouzia N Aboobacker Anup J Devasia Anu Korula Aby Abraham Biju George Paul V George Alok Srivastava |
| author_facet | Amal Paul Uday Kulkarni Bijesh Yadav Fouzia N Aboobacker Anup J Devasia Anu Korula Aby Abraham Biju George Paul V George Alok Srivastava |
| author_sort | Amal Paul |
| collection | DOAJ |
| description | <h4>Aims</h4>Long term survivors of haematopoietic stem cell transplantation (HSCT) for β-thalassemia major are designated "ex-thalassaemics". Whether ex-thalassaemics continue to harbour residual myocardial dysfunction and thereby stand the risk of heart failure-related morbidity and mortality is unknown. The aim of this study was to assess the prevalence and predictors of subclinical left ventricular (LV) dysfunction in an apparently normal ex-thalassaemic population.<h4>Methods</h4>We conducted a single centre cross-sectional study among 62 ex-thalassaemic patients, who had undergone HSCT for β-thalassaemia major at our centre. The primary outcome variable was LV systolic dysfunction, as assessed by 1) LV global longitudinal strain (GLS) derived by 2D speckle tracking echocardiography and 2) LV ejection fraction (EF) derived by 2D Simpsons Biplane method.<h4>Results</h4>Among the 62 patients included in the study, 7 [11.3%] were found to have LV systolic dysfunction, all of which were subclinical. Of these, 4 [6.5%] had abnormal GLS and LVEF, 2 [3.2%] had abnormal GLS with normal LVEF, and 1 [1.6%] had abnormal LVEF with low normal mean GLS. There were no statistically significant predictors of LV dysfunction in this cohort.<h4>Conclusion</h4>There was a high prevalence of subclinical myocardial dysfunction in the ex-thalassaemic population reiterating the need for close follow up of these patients. 2D Speckle tracking echocardiography-derived LV global longitudinal strain is an effective tool in detecting subclinical myocardial dysfunction in this cohort. |
| first_indexed | 2024-03-11T12:18:38Z |
| format | Article |
| id | doaj.art-53d7518bdd054b19a35de8509acafe39 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-03-11T12:18:38Z |
| publishDate | 2023-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-53d7518bdd054b19a35de8509acafe392023-11-07T05:34:50ZengPublic Library of Science (PLoS)PLoS ONE1932-62032023-01-011811e029345210.1371/journal.pone.0293452Speckle tracking echocardiography-derived left ventricular global longitudinal strain in ex-thalassaemics.Amal PaulUday KulkarniBijesh YadavFouzia N AboobackerAnup J DevasiaAnu KorulaAby AbrahamBiju GeorgePaul V GeorgeAlok Srivastava<h4>Aims</h4>Long term survivors of haematopoietic stem cell transplantation (HSCT) for β-thalassemia major are designated "ex-thalassaemics". Whether ex-thalassaemics continue to harbour residual myocardial dysfunction and thereby stand the risk of heart failure-related morbidity and mortality is unknown. The aim of this study was to assess the prevalence and predictors of subclinical left ventricular (LV) dysfunction in an apparently normal ex-thalassaemic population.<h4>Methods</h4>We conducted a single centre cross-sectional study among 62 ex-thalassaemic patients, who had undergone HSCT for β-thalassaemia major at our centre. The primary outcome variable was LV systolic dysfunction, as assessed by 1) LV global longitudinal strain (GLS) derived by 2D speckle tracking echocardiography and 2) LV ejection fraction (EF) derived by 2D Simpsons Biplane method.<h4>Results</h4>Among the 62 patients included in the study, 7 [11.3%] were found to have LV systolic dysfunction, all of which were subclinical. Of these, 4 [6.5%] had abnormal GLS and LVEF, 2 [3.2%] had abnormal GLS with normal LVEF, and 1 [1.6%] had abnormal LVEF with low normal mean GLS. There were no statistically significant predictors of LV dysfunction in this cohort.<h4>Conclusion</h4>There was a high prevalence of subclinical myocardial dysfunction in the ex-thalassaemic population reiterating the need for close follow up of these patients. 2D Speckle tracking echocardiography-derived LV global longitudinal strain is an effective tool in detecting subclinical myocardial dysfunction in this cohort.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0293452&type=printable |
| spellingShingle | Amal Paul Uday Kulkarni Bijesh Yadav Fouzia N Aboobacker Anup J Devasia Anu Korula Aby Abraham Biju George Paul V George Alok Srivastava Speckle tracking echocardiography-derived left ventricular global longitudinal strain in ex-thalassaemics. PLoS ONE |
| title | Speckle tracking echocardiography-derived left ventricular global longitudinal strain in ex-thalassaemics. |
| title_full | Speckle tracking echocardiography-derived left ventricular global longitudinal strain in ex-thalassaemics. |
| title_fullStr | Speckle tracking echocardiography-derived left ventricular global longitudinal strain in ex-thalassaemics. |
| title_full_unstemmed | Speckle tracking echocardiography-derived left ventricular global longitudinal strain in ex-thalassaemics. |
| title_short | Speckle tracking echocardiography-derived left ventricular global longitudinal strain in ex-thalassaemics. |
| title_sort | speckle tracking echocardiography derived left ventricular global longitudinal strain in ex thalassaemics |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0293452&type=printable |
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