Aegle Marmelos Enhances Gastric Mucosal Protection: Relevance for NSAIDS-Induced Gastric Mucosal Injury
Objective: In order to study the gastroprotective effect of Aegle marmelos extract (AM), this study was undertaken on aspirin-induced ulcerogenesis in cannulated free-moving rats. Background: Most of the non-steroidal anti-inflammatory drugs (NSAIDs) including aspirin (ASP) cause gastric ulcer. The...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Al Ameen Medical College
2012-07-01
|
| Series: | Al Ameen Journal of Medical Sciences |
| Subjects: | |
| Online Access: | http://ajms.alameenmedical.org/ArticlePDFs%5CAJMS%20V5.N3.2012%20p%20243-255.pdf |
| _version_ | 1818521404965912576 |
|---|---|
| author | P.Singh D.Guha |
| author_facet | P.Singh D.Guha |
| author_sort | P.Singh |
| collection | DOAJ |
| description | Objective: In order to study the gastroprotective effect of Aegle marmelos extract (AM), this study was undertaken on aspirin-induced ulcerogenesis in cannulated free-moving rats. Background: Most of the non-steroidal anti-inflammatory drugs (NSAIDs) including aspirin (ASP) cause gastric ulcer. The efficacy of several plants for the treatment of gastroduodenal disease is confirmed by clinical research, while basic scientific research helps us to uncover the mechanisms by which these plants exert their therapeutic effects. Method: To assess the possible antiulcer effect of AM, lesion index, gastric secretions glycoprotein levels and mucosal histopathology were determined in ASP induced gastric mucosal injury in cannulated free-moving rats. Results: Pretreatment with AM significantly prevented the development of gastric mucosal lesion and decreased the gastric toxicity produced by ulcerogen. In addition, ulcerated rats showed depletion of gastric wall mucus, glycoproteins and enhanced gastric acid secretion whereas treatment with AM prevented these ASP induced responses in cannulated free-moving rats. Histological studies confirmed the results. Conclusion: The present finding suggests that AM promotes ulcer protection by the decrease in ulcer index, gastric secretions and increase in the glycoprotein level, gastric mucin content and maintenance of mucosal epithelium. AM protects the gastric mucosa against ulceration by its antisecretory and cytoprotective property. |
| first_indexed | 2024-12-11T01:50:34Z |
| format | Article |
| id | doaj.art-53d7d349ceaa4cf0ba22b00bf04b42a9 |
| institution | Directory Open Access Journal |
| issn | 0974-1143 |
| language | English |
| last_indexed | 2024-12-11T01:50:34Z |
| publishDate | 2012-07-01 |
| publisher | Al Ameen Medical College |
| record_format | Article |
| series | Al Ameen Journal of Medical Sciences |
| spelling | doaj.art-53d7d349ceaa4cf0ba22b00bf04b42a92022-12-22T01:24:46ZengAl Ameen Medical CollegeAl Ameen Journal of Medical Sciences0974-11432012-07-010503243255Aegle Marmelos Enhances Gastric Mucosal Protection: Relevance for NSAIDS-Induced Gastric Mucosal InjuryP.SinghD.GuhaObjective: In order to study the gastroprotective effect of Aegle marmelos extract (AM), this study was undertaken on aspirin-induced ulcerogenesis in cannulated free-moving rats. Background: Most of the non-steroidal anti-inflammatory drugs (NSAIDs) including aspirin (ASP) cause gastric ulcer. The efficacy of several plants for the treatment of gastroduodenal disease is confirmed by clinical research, while basic scientific research helps us to uncover the mechanisms by which these plants exert their therapeutic effects. Method: To assess the possible antiulcer effect of AM, lesion index, gastric secretions glycoprotein levels and mucosal histopathology were determined in ASP induced gastric mucosal injury in cannulated free-moving rats. Results: Pretreatment with AM significantly prevented the development of gastric mucosal lesion and decreased the gastric toxicity produced by ulcerogen. In addition, ulcerated rats showed depletion of gastric wall mucus, glycoproteins and enhanced gastric acid secretion whereas treatment with AM prevented these ASP induced responses in cannulated free-moving rats. Histological studies confirmed the results. Conclusion: The present finding suggests that AM promotes ulcer protection by the decrease in ulcer index, gastric secretions and increase in the glycoprotein level, gastric mucin content and maintenance of mucosal epithelium. AM protects the gastric mucosa against ulceration by its antisecretory and cytoprotective property.http://ajms.alameenmedical.org/ArticlePDFs%5CAJMS%20V5.N3.2012%20p%20243-255.pdfAntiulcer activityaspirinAegle marmelos extracthistopathologymucus content |
| spellingShingle | P.Singh D.Guha Aegle Marmelos Enhances Gastric Mucosal Protection: Relevance for NSAIDS-Induced Gastric Mucosal Injury Al Ameen Journal of Medical Sciences Antiulcer activity aspirin Aegle marmelos extract histopathology mucus content |
| title | Aegle Marmelos Enhances Gastric Mucosal Protection: Relevance for NSAIDS-Induced Gastric Mucosal Injury |
| title_full | Aegle Marmelos Enhances Gastric Mucosal Protection: Relevance for NSAIDS-Induced Gastric Mucosal Injury |
| title_fullStr | Aegle Marmelos Enhances Gastric Mucosal Protection: Relevance for NSAIDS-Induced Gastric Mucosal Injury |
| title_full_unstemmed | Aegle Marmelos Enhances Gastric Mucosal Protection: Relevance for NSAIDS-Induced Gastric Mucosal Injury |
| title_short | Aegle Marmelos Enhances Gastric Mucosal Protection: Relevance for NSAIDS-Induced Gastric Mucosal Injury |
| title_sort | aegle marmelos enhances gastric mucosal protection relevance for nsaids induced gastric mucosal injury |
| topic | Antiulcer activity aspirin Aegle marmelos extract histopathology mucus content |
| url | http://ajms.alameenmedical.org/ArticlePDFs%5CAJMS%20V5.N3.2012%20p%20243-255.pdf |
| work_keys_str_mv | AT psingh aeglemarmelosenhancesgastricmucosalprotectionrelevancefornsaidsinducedgastricmucosalinjury AT dguha aeglemarmelosenhancesgastricmucosalprotectionrelevancefornsaidsinducedgastricmucosalinjury |