Survival Trends in Pediatric Differentiated Thyroid Cancer: A Middle Eastern Perspective
Pediatric Differentiated Thyroid Cancer (pedDTC) is a rare pediatric malignancy with an increasing incidence over time. To date, there is a paucity of literature specifically addressing pedDTC within the context of Middle Eastern ethnicity. This retrospective study aimed to assess the risk-stratifyi...
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| Format: | Article |
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MDPI AG
2024-01-01
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| Online Access: | https://www.mdpi.com/2075-1729/14/1/158 |
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| author | Akram Al-Ibraheem Mohamed Al-Shammaa Ahmed Saad Abdlkadir Feras Istatieh Ula Al-Rasheed Thomas Pascual Rawad Rihani Hadeel Halalsheh Taleb Ismael Aysar Khalaf Iyad Sultan Issa Mohamad Hikmat Abdel-Razeq Asem Mansour |
| author_facet | Akram Al-Ibraheem Mohamed Al-Shammaa Ahmed Saad Abdlkadir Feras Istatieh Ula Al-Rasheed Thomas Pascual Rawad Rihani Hadeel Halalsheh Taleb Ismael Aysar Khalaf Iyad Sultan Issa Mohamad Hikmat Abdel-Razeq Asem Mansour |
| author_sort | Akram Al-Ibraheem |
| collection | DOAJ |
| description | Pediatric Differentiated Thyroid Cancer (pedDTC) is a rare pediatric malignancy with an increasing incidence over time. To date, there is a paucity of literature specifically addressing pedDTC within the context of Middle Eastern ethnicity. This retrospective study aimed to assess the risk-stratifying factors for overall survival (OS) and event-free survival (EFS) in pediatric DTC patients from Iraq and Jordan. The medical records of 81 patients from two tertiary cancer institutes were retrieved. Kaplan–Meier analysis was employed to investigate OS and EFS, and the Cox proportional hazards model was employed to estimate hazard ratios. All patients underwent surgery and radioactive iodine therapy, with a median age of 14 and an interquartile range of 12–15. Lymph node involvement was observed in 55% of cases, while distant metastases were present in 13.5%. After a median follow-up period of 68 months, the 10-year survival rate was determined to be 94%, while the 10-year EFS rate was 58%. EFS was negatively impacted by cervical lymph node metastases and early age of diagnosis (<i>p</i> ≤ 0.01, each). Therefore, pediatrics with initial cervical lymph node metastases and those diagnosed before puberty tend to experience poorer EFS, which may justify the need for more aggressive management plans. |
| first_indexed | 2024-03-08T10:43:11Z |
| format | Article |
| id | doaj.art-53d8e8307a024da4bfecb7624310186b |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-08T10:43:11Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-53d8e8307a024da4bfecb7624310186b2024-01-26T17:21:54ZengMDPI AGLife2075-17292024-01-0114115810.3390/life14010158Survival Trends in Pediatric Differentiated Thyroid Cancer: A Middle Eastern PerspectiveAkram Al-Ibraheem0Mohamed Al-Shammaa1Ahmed Saad Abdlkadir2Feras Istatieh3Ula Al-Rasheed4Thomas Pascual5Rawad Rihani6Hadeel Halalsheh7Taleb Ismael8Aysar Khalaf9Iyad Sultan10Issa Mohamad11Hikmat Abdel-Razeq12Asem Mansour13Department of Nuclear Medicine and PET/CT, King Hussein Cancer Center (KHCC), Al-Jubeiha, Amman 11941, JordanDepartment of Nuclear Medicine, Radiotherapy and Nuclear Medicine Hospital, Bab Al-Muadham, Baghdad 10047, IraqDepartment of Nuclear Medicine and PET/CT, King Hussein Cancer Center (KHCC), Al-Jubeiha, Amman 11941, JordanDepartment of Nuclear Medicine and PET/CT, King Hussein Cancer Center (KHCC), Al-Jubeiha, Amman 11941, JordanDepartment of Nuclear Medicine and PET/CT, King Hussein Cancer Center (KHCC), Al-Jubeiha, Amman 11941, JordanPhilippine Nuclear Research Institute, Department of Science and Technology, Quezon City 1101, PhilippinesDepartment of Pediatrics, King Hussein Cancer Center (KHCC), Al-Jubeiha, Amman 11941, JordanDepartment of Pediatrics, King Hussein Cancer Center (KHCC), Al-Jubeiha, Amman 11941, JordanDepartment of Pediatrics, King Hussein Cancer Center (KHCC), Al-Jubeiha, Amman 11941, JordanDepartment of Nuclear Medicine, Warith International Cancer Institute, Karbala 56001, IraqDepartment of Pediatrics, King Hussein Cancer Center (KHCC), Al-Jubeiha, Amman 11941, JordanDepartment of Radiation Oncology, King Hussein Cancer Center (KHCC), Al-Jubeiha, Amman 11941, JordanDepartment of Medicine, King Hussein Cancer Center (KHCC), Al-Jubeiha, Amman 11941, JordanDepartment of Diagnostic Radiology, King Hussein Cancer Center (KHCC), Al-Jubeiha, Amman 11941, JordanPediatric Differentiated Thyroid Cancer (pedDTC) is a rare pediatric malignancy with an increasing incidence over time. To date, there is a paucity of literature specifically addressing pedDTC within the context of Middle Eastern ethnicity. This retrospective study aimed to assess the risk-stratifying factors for overall survival (OS) and event-free survival (EFS) in pediatric DTC patients from Iraq and Jordan. The medical records of 81 patients from two tertiary cancer institutes were retrieved. Kaplan–Meier analysis was employed to investigate OS and EFS, and the Cox proportional hazards model was employed to estimate hazard ratios. All patients underwent surgery and radioactive iodine therapy, with a median age of 14 and an interquartile range of 12–15. Lymph node involvement was observed in 55% of cases, while distant metastases were present in 13.5%. After a median follow-up period of 68 months, the 10-year survival rate was determined to be 94%, while the 10-year EFS rate was 58%. EFS was negatively impacted by cervical lymph node metastases and early age of diagnosis (<i>p</i> ≤ 0.01, each). Therefore, pediatrics with initial cervical lymph node metastases and those diagnosed before puberty tend to experience poorer EFS, which may justify the need for more aggressive management plans.https://www.mdpi.com/2075-1729/14/1/158pediatric thyroid cancerMiddle Easternevent-free survivalchildrendistant metastasislymph node metastasis |
| spellingShingle | Akram Al-Ibraheem Mohamed Al-Shammaa Ahmed Saad Abdlkadir Feras Istatieh Ula Al-Rasheed Thomas Pascual Rawad Rihani Hadeel Halalsheh Taleb Ismael Aysar Khalaf Iyad Sultan Issa Mohamad Hikmat Abdel-Razeq Asem Mansour Survival Trends in Pediatric Differentiated Thyroid Cancer: A Middle Eastern Perspective Life pediatric thyroid cancer Middle Eastern event-free survival children distant metastasis lymph node metastasis |
| title | Survival Trends in Pediatric Differentiated Thyroid Cancer: A Middle Eastern Perspective |
| title_full | Survival Trends in Pediatric Differentiated Thyroid Cancer: A Middle Eastern Perspective |
| title_fullStr | Survival Trends in Pediatric Differentiated Thyroid Cancer: A Middle Eastern Perspective |
| title_full_unstemmed | Survival Trends in Pediatric Differentiated Thyroid Cancer: A Middle Eastern Perspective |
| title_short | Survival Trends in Pediatric Differentiated Thyroid Cancer: A Middle Eastern Perspective |
| title_sort | survival trends in pediatric differentiated thyroid cancer a middle eastern perspective |
| topic | pediatric thyroid cancer Middle Eastern event-free survival children distant metastasis lymph node metastasis |
| url | https://www.mdpi.com/2075-1729/14/1/158 |
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