Salivary tumor necrosis factor–Alpha and malondialdehyde levels in children with class II malocclusion and sleep disorders: An evaluative study
Context: Recently biomarkers for sleep disorders have provided an alternative and convenient means of diagnosis for children at risk. Aim: To evaluate salivary TNF-α and Malondialdehyde (MDA) levels in children with skeletal class II malocclusion and with a positive history of sleep disorders. Setti...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2022-01-01
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| Series: | Indian Journal of Dental Research |
| Subjects: | |
| Online Access: | http://www.ijdr.in/article.asp?issn=0970-9290;year=2022;volume=33;issue=1;spage=18;epage=23;aulast=Prabhu |
| _version_ | 1811275830167339008 |
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| author | Nagashree Prabhu Vabitha Shetty |
| author_facet | Nagashree Prabhu Vabitha Shetty |
| author_sort | Nagashree Prabhu |
| collection | DOAJ |
| description | Context: Recently biomarkers for sleep disorders have provided an alternative and convenient means of diagnosis for children at risk. Aim: To evaluate salivary TNF-α and Malondialdehyde (MDA) levels in children with skeletal class II malocclusion and with a positive history of sleep disorders. Settings and Design: This prospective evaluative study was carried out from October 2020 to March 2021, in the Department of Pediatric and Preventive Dentistry. Material and Methods: 21 children aged 8-12 years with skeletal class II malocclusion and at least one sleep disorder participated in the study (Group 1). 21 age and gender matched children with no skeletal malocclusion and no reported history of sleep disorders served as a comparison group (Group 2). All children were evaluated regarding their sleep history and clinically examined to determine craniofacial morphology. Unstimulated saliva was collected from all children. Salivary TNF-α was measured with a solid-phase sandwich ELISA. Salivary MDA was measured by using TBA reagent. Statistical Analysis: Intergroup comparison for age and normally distributed data was done using t-test. Comparison of frequencies of categories of variables was done using Chi-square test. Inter group comparison for TNF-α was done using Mann–Whitney U test. Results: There were significantly higher levels of salivary TNF-α and MDA, in children of Group 1 when compared to that of Group 2 children (p < 0.01). Conclusion: Salivary TNF-α and MDA may be a simple and non-invasive tool in the identification and screening of children at high risk for sleep disorders. |
| first_indexed | 2024-04-12T23:45:39Z |
| format | Article |
| id | doaj.art-53d9a624c8be4c7c9a583725e7b6f1e7 |
| institution | Directory Open Access Journal |
| issn | 0970-9290 1998-3603 |
| language | English |
| last_indexed | 2024-04-12T23:45:39Z |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Dental Research |
| spelling | doaj.art-53d9a624c8be4c7c9a583725e7b6f1e72022-12-22T03:11:52ZengWolters Kluwer Medknow PublicationsIndian Journal of Dental Research0970-92901998-36032022-01-01331182310.4103/ijdr.ijdr_1103_21Salivary tumor necrosis factor–Alpha and malondialdehyde levels in children with class II malocclusion and sleep disorders: An evaluative studyNagashree PrabhuVabitha ShettyContext: Recently biomarkers for sleep disorders have provided an alternative and convenient means of diagnosis for children at risk. Aim: To evaluate salivary TNF-α and Malondialdehyde (MDA) levels in children with skeletal class II malocclusion and with a positive history of sleep disorders. Settings and Design: This prospective evaluative study was carried out from October 2020 to March 2021, in the Department of Pediatric and Preventive Dentistry. Material and Methods: 21 children aged 8-12 years with skeletal class II malocclusion and at least one sleep disorder participated in the study (Group 1). 21 age and gender matched children with no skeletal malocclusion and no reported history of sleep disorders served as a comparison group (Group 2). All children were evaluated regarding their sleep history and clinically examined to determine craniofacial morphology. Unstimulated saliva was collected from all children. Salivary TNF-α was measured with a solid-phase sandwich ELISA. Salivary MDA was measured by using TBA reagent. Statistical Analysis: Intergroup comparison for age and normally distributed data was done using t-test. Comparison of frequencies of categories of variables was done using Chi-square test. Inter group comparison for TNF-α was done using Mann–Whitney U test. Results: There were significantly higher levels of salivary TNF-α and MDA, in children of Group 1 when compared to that of Group 2 children (p < 0.01). Conclusion: Salivary TNF-α and MDA may be a simple and non-invasive tool in the identification and screening of children at high risk for sleep disorders.http://www.ijdr.in/article.asp?issn=0970-9290;year=2022;volume=33;issue=1;spage=18;epage=23;aulast=Prabhubiomarkerchildrenmalondialdehydesleep disorderstumor necrosis factor-alpha |
| spellingShingle | Nagashree Prabhu Vabitha Shetty Salivary tumor necrosis factor–Alpha and malondialdehyde levels in children with class II malocclusion and sleep disorders: An evaluative study Indian Journal of Dental Research biomarker children malondialdehyde sleep disorders tumor necrosis factor-alpha |
| title | Salivary tumor necrosis factor–Alpha and malondialdehyde levels in children with class II malocclusion and sleep disorders: An evaluative study |
| title_full | Salivary tumor necrosis factor–Alpha and malondialdehyde levels in children with class II malocclusion and sleep disorders: An evaluative study |
| title_fullStr | Salivary tumor necrosis factor–Alpha and malondialdehyde levels in children with class II malocclusion and sleep disorders: An evaluative study |
| title_full_unstemmed | Salivary tumor necrosis factor–Alpha and malondialdehyde levels in children with class II malocclusion and sleep disorders: An evaluative study |
| title_short | Salivary tumor necrosis factor–Alpha and malondialdehyde levels in children with class II malocclusion and sleep disorders: An evaluative study |
| title_sort | salivary tumor necrosis factor alpha and malondialdehyde levels in children with class ii malocclusion and sleep disorders an evaluative study |
| topic | biomarker children malondialdehyde sleep disorders tumor necrosis factor-alpha |
| url | http://www.ijdr.in/article.asp?issn=0970-9290;year=2022;volume=33;issue=1;spage=18;epage=23;aulast=Prabhu |
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