Olfaction and neurocognition after COVID-19: a scoping review
IntroductionCOVID-19 induces both acute and chronic neurological changes. Existing evidence suggests that chemosensory changes, particularly olfactory loss, may reflect central neurological dysfunction in neurodegenerative diseases and mark progression from mild cognitive impairment to Alzheimer’s....
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-06-01
|
| Series: | Frontiers in Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2023.1198267/full |
| _version_ | 1797792288935510016 |
|---|---|
| author | Brandon J. Vilarello Patricia T. Jacobson Jeremy P. Tervo Nicholas A. Waring David A. Gudis David A. Gudis Terry E. Goldberg D. P. Devanand D. P. Devanand Jonathan B. Overdevest Jonathan B. Overdevest |
| author_facet | Brandon J. Vilarello Patricia T. Jacobson Jeremy P. Tervo Nicholas A. Waring David A. Gudis David A. Gudis Terry E. Goldberg D. P. Devanand D. P. Devanand Jonathan B. Overdevest Jonathan B. Overdevest |
| author_sort | Brandon J. Vilarello |
| collection | DOAJ |
| description | IntroductionCOVID-19 induces both acute and chronic neurological changes. Existing evidence suggests that chemosensory changes, particularly olfactory loss, may reflect central neurological dysfunction in neurodegenerative diseases and mark progression from mild cognitive impairment to Alzheimer’s. This scoping review summarizes the available literature to evaluate the relationship between neurocognition and olfaction in young to middle-aged adults with minimal comorbidities following COVID-19 infection.MethodsA literature search of PubMed, Ovid Embase, Web of Science, and Cochrane Library was conducted. Studies underwent title/abstract and full text screening by two reviewers, with a third reviewer resolving any conflicts. Remaining studies underwent data extraction.ResultsSeventeen studies were eligible for data extraction after the review process, where 12 studies found significantly poorer cognition in those suffering from olfactory dysfunction, four studies showed no association between cognition and olfaction, and one study reported lower anosmia prevalence among patients with cognitive impairment.ConclusionThe majority of studies in this review find that olfactory dysfunction is associated with poorer cognition. More rigorous studies are needed to further elucidate the relationship between olfaction and cognition after COVID-19. |
| first_indexed | 2024-03-13T02:31:02Z |
| format | Article |
| id | doaj.art-53db9315d00941b5ad536a226e642ddd |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-03-13T02:31:02Z |
| publishDate | 2023-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-53db9315d00941b5ad536a226e642ddd2023-06-29T16:37:13ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2023-06-011710.3389/fnins.2023.11982671198267Olfaction and neurocognition after COVID-19: a scoping reviewBrandon J. Vilarello0Patricia T. Jacobson1Jeremy P. Tervo2Nicholas A. Waring3David A. Gudis4David A. Gudis5Terry E. Goldberg6D. P. Devanand7D. P. Devanand8Jonathan B. Overdevest9Jonathan B. Overdevest10Columbia University Vagelos College of Physicians and Surgeons, New York, NY, United StatesDepartment of Otolaryngology-Head and Neck Surgery, New York-Presbyterian/Columbia University Irving Medical Center, New York, NY, United StatesColumbia University Vagelos College of Physicians and Surgeons, New York, NY, United StatesColumbia University Vagelos College of Physicians and Surgeons, New York, NY, United StatesColumbia University Vagelos College of Physicians and Surgeons, New York, NY, United StatesDepartment of Otolaryngology-Head and Neck Surgery, New York-Presbyterian/Columbia University Irving Medical Center, New York, NY, United StatesDepartment of Psychiatry, New York-Presbyterian/Columbia University Irving Medical Center, New York, NY, United StatesColumbia University Vagelos College of Physicians and Surgeons, New York, NY, United StatesDepartment of Psychiatry, New York-Presbyterian/Columbia University Irving Medical Center, New York, NY, United StatesColumbia University Vagelos College of Physicians and Surgeons, New York, NY, United StatesDepartment of Otolaryngology-Head and Neck Surgery, New York-Presbyterian/Columbia University Irving Medical Center, New York, NY, United StatesIntroductionCOVID-19 induces both acute and chronic neurological changes. Existing evidence suggests that chemosensory changes, particularly olfactory loss, may reflect central neurological dysfunction in neurodegenerative diseases and mark progression from mild cognitive impairment to Alzheimer’s. This scoping review summarizes the available literature to evaluate the relationship between neurocognition and olfaction in young to middle-aged adults with minimal comorbidities following COVID-19 infection.MethodsA literature search of PubMed, Ovid Embase, Web of Science, and Cochrane Library was conducted. Studies underwent title/abstract and full text screening by two reviewers, with a third reviewer resolving any conflicts. Remaining studies underwent data extraction.ResultsSeventeen studies were eligible for data extraction after the review process, where 12 studies found significantly poorer cognition in those suffering from olfactory dysfunction, four studies showed no association between cognition and olfaction, and one study reported lower anosmia prevalence among patients with cognitive impairment.ConclusionThe majority of studies in this review find that olfactory dysfunction is associated with poorer cognition. More rigorous studies are needed to further elucidate the relationship between olfaction and cognition after COVID-19.https://www.frontiersin.org/articles/10.3389/fnins.2023.1198267/fullCOVIDneurocognitionolfactionreviewPASC |
| spellingShingle | Brandon J. Vilarello Patricia T. Jacobson Jeremy P. Tervo Nicholas A. Waring David A. Gudis David A. Gudis Terry E. Goldberg D. P. Devanand D. P. Devanand Jonathan B. Overdevest Jonathan B. Overdevest Olfaction and neurocognition after COVID-19: a scoping review Frontiers in Neuroscience COVID neurocognition olfaction review PASC |
| title | Olfaction and neurocognition after COVID-19: a scoping review |
| title_full | Olfaction and neurocognition after COVID-19: a scoping review |
| title_fullStr | Olfaction and neurocognition after COVID-19: a scoping review |
| title_full_unstemmed | Olfaction and neurocognition after COVID-19: a scoping review |
| title_short | Olfaction and neurocognition after COVID-19: a scoping review |
| title_sort | olfaction and neurocognition after covid 19 a scoping review |
| topic | COVID neurocognition olfaction review PASC |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2023.1198267/full |
| work_keys_str_mv | AT brandonjvilarello olfactionandneurocognitionaftercovid19ascopingreview AT patriciatjacobson olfactionandneurocognitionaftercovid19ascopingreview AT jeremyptervo olfactionandneurocognitionaftercovid19ascopingreview AT nicholasawaring olfactionandneurocognitionaftercovid19ascopingreview AT davidagudis olfactionandneurocognitionaftercovid19ascopingreview AT davidagudis olfactionandneurocognitionaftercovid19ascopingreview AT terryegoldberg olfactionandneurocognitionaftercovid19ascopingreview AT dpdevanand olfactionandneurocognitionaftercovid19ascopingreview AT dpdevanand olfactionandneurocognitionaftercovid19ascopingreview AT jonathanboverdevest olfactionandneurocognitionaftercovid19ascopingreview AT jonathanboverdevest olfactionandneurocognitionaftercovid19ascopingreview |