An Entire Process Optimization Strategy for Comprehensive In Vivo Metabolite Profiling of Prucalopride in Rats Based on Ultra-Performance Liquid Chromatography With Q-Exactive Hybrid Quadrupole–Orbitrap High-Resolution Mass Spectrometry

An Entire Process Optimization Strategy for Comprehensive In Vivo Metabolite Profiling of Prucalopride in Rats Based on Ultra-Performance Liquid Chromatography With Q-Exactive Hybrid Quadrupole–Orbitrap High-Resolution Mass Spectrometry

Prucalopride was widely used for chronic constipation, which is difficult to be adequately relieved by laxatives in adult patients in clinic. Due to the difficulty in metabolite identification, metabolic process of prucalopride had not been investigated in vivo. In this study, an efficient strategy...

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Bibliographic Details
Main Authors: Lihua Zuo, Liwei Liu, Yantao Yang, Jie Yang, Min Chen, Huafeng Zhang, Jian Kang, Xiaojian Zhang, Jiabo Wang, Zhi Sun
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Pharmacology
Subjects:
prucalopride
metabolite identification
high-resolution mass spectrometry
the entire and novel strategy
metabolic network
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.610226/full

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