14,15-Secopregnane-Type Glycosides with 5α:9α-Peroxy and Δ6,8(14)-diene Linkages from the Roots of Cynanchum stauntonii
Three new 14,15-secopregnane-type glycosides, stauntosides UA, UA1, and UA2, were isolated from the roots of Cynanchum stauntonii. The three compounds share the first reported and same basic structural features of 3β-hydroxy-14:16,15:20,18:20-triepoxy-5α:9α-peroxy-14,15-secopregnane-6,8(14)-diene na...
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MDPI AG
2017-05-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/22/6/860 |
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| author | An-Jun Deng Jin-Qian Yu Zhi-Hong Li Lin Ma Zhi-Hui Zhang Hai-Lin Qin |
| author_facet | An-Jun Deng Jin-Qian Yu Zhi-Hong Li Lin Ma Zhi-Hui Zhang Hai-Lin Qin |
| author_sort | An-Jun Deng |
| collection | DOAJ |
| description | Three new 14,15-secopregnane-type glycosides, stauntosides UA, UA1, and UA2, were isolated from the roots of Cynanchum stauntonii. The three compounds share the first reported and same basic structural features of 3β-hydroxy-14:16,15:20,18:20-triepoxy-5α:9α-peroxy-14,15-secopregnane-6,8(14)-diene named as stauntogenin G as the aglycones. The structures of the new compounds were characterized on the basis of extensive spectroscopic analyses, mainly 1D and 2D NMR and MS methods and chemical analysis. The isolation and identification of the new compounds graced the structural diversity of pregnane-type steroids from C. stauntonii. |
| first_indexed | 2024-12-12T15:44:57Z |
| format | Article |
| id | doaj.art-53dd04b7ec6043189b01743762be07e0 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-12T15:44:57Z |
| publishDate | 2017-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-53dd04b7ec6043189b01743762be07e02022-12-22T00:19:47ZengMDPI AGMolecules1420-30492017-05-0122686010.3390/molecules22060860molecules2206086014,15-Secopregnane-Type Glycosides with 5α:9α-Peroxy and Δ6,8(14)-diene Linkages from the Roots of Cynanchum stauntoniiAn-Jun Deng0Jin-Qian Yu1Zhi-Hong Li2Lin Ma3Zhi-Hui Zhang4Hai-Lin Qin5State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, ChinaState Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, ChinaState Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, ChinaState Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, ChinaState Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, ChinaState Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, ChinaThree new 14,15-secopregnane-type glycosides, stauntosides UA, UA1, and UA2, were isolated from the roots of Cynanchum stauntonii. The three compounds share the first reported and same basic structural features of 3β-hydroxy-14:16,15:20,18:20-triepoxy-5α:9α-peroxy-14,15-secopregnane-6,8(14)-diene named as stauntogenin G as the aglycones. The structures of the new compounds were characterized on the basis of extensive spectroscopic analyses, mainly 1D and 2D NMR and MS methods and chemical analysis. The isolation and identification of the new compounds graced the structural diversity of pregnane-type steroids from C. stauntonii.http://www.mdpi.com/1420-3049/22/6/860Cynanchum stauntoniiAsclepiadaceae14,15-secopregnane-type glycosidestauntogenin G5α:9α-peroxy linkagestauntosides UA, UA1, and UA2structure elucidation |
| spellingShingle | An-Jun Deng Jin-Qian Yu Zhi-Hong Li Lin Ma Zhi-Hui Zhang Hai-Lin Qin 14,15-Secopregnane-Type Glycosides with 5α:9α-Peroxy and Δ6,8(14)-diene Linkages from the Roots of Cynanchum stauntonii Molecules Cynanchum stauntonii Asclepiadaceae 14,15-secopregnane-type glycoside stauntogenin G 5α:9α-peroxy linkage stauntosides UA, UA1, and UA2 structure elucidation |
| title | 14,15-Secopregnane-Type Glycosides with 5α:9α-Peroxy and Δ6,8(14)-diene Linkages from the Roots of Cynanchum stauntonii |
| title_full | 14,15-Secopregnane-Type Glycosides with 5α:9α-Peroxy and Δ6,8(14)-diene Linkages from the Roots of Cynanchum stauntonii |
| title_fullStr | 14,15-Secopregnane-Type Glycosides with 5α:9α-Peroxy and Δ6,8(14)-diene Linkages from the Roots of Cynanchum stauntonii |
| title_full_unstemmed | 14,15-Secopregnane-Type Glycosides with 5α:9α-Peroxy and Δ6,8(14)-diene Linkages from the Roots of Cynanchum stauntonii |
| title_short | 14,15-Secopregnane-Type Glycosides with 5α:9α-Peroxy and Δ6,8(14)-diene Linkages from the Roots of Cynanchum stauntonii |
| title_sort | 14 15 secopregnane type glycosides with 5α 9α peroxy and δ6 8 14 diene linkages from the roots of cynanchum stauntonii |
| topic | Cynanchum stauntonii Asclepiadaceae 14,15-secopregnane-type glycoside stauntogenin G 5α:9α-peroxy linkage stauntosides UA, UA1, and UA2 structure elucidation |
| url | http://www.mdpi.com/1420-3049/22/6/860 |
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