Increased Reflux Esophagitis after <i>Helicobacter pylori</i> Eradication Therapy in Cases Undergoing Endoscopic Submucosal Dissection for Early Gastric Cancer
Background: The role of <i>Helicobacter pylori</i> in the pathogenesis of reflux esophagitis is controversial. This study investigated the frequency of reflux esophagitis before and after <i>H. pylori</i> eradication in patients having endoscopic submucosal dissection for ear...
Main Authors: | , , , , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2021-04-01
|
Series: | Cancers |
Subjects: | |
Online Access: | https://www.mdpi.com/2072-6694/13/8/1779 |
_version_ | 1797538389008842752 |
---|---|
author | Masaki Katsurahara Ichiro Imoto Yuhei Umeda Hiroshi Miura Junya Tsuboi Reiko Yamada Taro Yasuma Misaki Nakamura Yasuhiko Hamada Hiroyuki Inoue Kyosuke Tanaka Noriyuki Horiki Esteban C. Gabazza Yoshiyuki Takei |
author_facet | Masaki Katsurahara Ichiro Imoto Yuhei Umeda Hiroshi Miura Junya Tsuboi Reiko Yamada Taro Yasuma Misaki Nakamura Yasuhiko Hamada Hiroyuki Inoue Kyosuke Tanaka Noriyuki Horiki Esteban C. Gabazza Yoshiyuki Takei |
author_sort | Masaki Katsurahara |
collection | DOAJ |
description | Background: The role of <i>Helicobacter pylori</i> in the pathogenesis of reflux esophagitis is controversial. This study investigated the frequency of reflux esophagitis before and after <i>H. pylori</i> eradication in patients having endoscopic submucosal dissection for early gastric cancer. Methods: This study included 160 patients that fulfilled the study’s criteria. Endoscopy was performed before and after <i>H. pylori</i> eradication, and reflux esophagitis was evaluated during the follow-up period. Results: Seropositivity for <i>H. pylori</i> in patients with early gastric cancer was 68.8%, 101 of them received eradication therapy. During the follow-up period, the incidence of reflux esophagitis increased from 3.1% to 18.8% in the successful eradication group but no case of reflux esophagitis was observed in the failed eradication group. The univariate and multivariate analyses showed a significant correlation between successful <i>H. pylori</i> eradication rate and the development of reflux esophagitis. Conclusions: This study demonstrated that a successful <i>H. pylori</i> eradication therapy is a risk factor for newly developed reflux esophagitis in patients with endoscopic submucosal dissection for early gastric cancer. |
first_indexed | 2024-03-10T12:30:50Z |
format | Article |
id | doaj.art-53decb0693c441a6a904411131e79e33 |
institution | Directory Open Access Journal |
issn | 2072-6694 |
language | English |
last_indexed | 2024-03-10T12:30:50Z |
publishDate | 2021-04-01 |
publisher | MDPI AG |
record_format | Article |
series | Cancers |
spelling | doaj.art-53decb0693c441a6a904411131e79e332023-11-21T14:41:18ZengMDPI AGCancers2072-66942021-04-01138177910.3390/cancers13081779Increased Reflux Esophagitis after <i>Helicobacter pylori</i> Eradication Therapy in Cases Undergoing Endoscopic Submucosal Dissection for Early Gastric CancerMasaki Katsurahara0Ichiro Imoto1Yuhei Umeda2Hiroshi Miura3Junya Tsuboi4Reiko Yamada5Taro Yasuma6Misaki Nakamura7Yasuhiko Hamada8Hiroyuki Inoue9Kyosuke Tanaka10Noriyuki Horiki11Esteban C. Gabazza12Yoshiyuki Takei13Department of Endoscopic Medicine, Mie University and Graduate School of Medicine, Edobashi 2-174, Tsu, Mie 514-8507, JapanDigestive Endoscopy Center, Doshinkai Tohyama Hospital, Minami-Shinmachi 17-22, Tsu, Mie 514-0043, JapanDepartment of Gastroenterology and Hepatology, Mie University Faculty and Graduate School of Medicine, Edobashi 2-174, Tsu, Mie 514-8507, JapanDepartment of Gastroenterology and Hepatology, Mie University Faculty and Graduate School of Medicine, Edobashi 2-174, Tsu, Mie 514-8507, JapanDepartment of Gastroenterology and Hepatology, Mie University Faculty and Graduate School of Medicine, Edobashi 2-174, Tsu, Mie 514-8507, JapanDepartment of Gastroenterology and Hepatology, Mie University Faculty and Graduate School of Medicine, Edobashi 2-174, Tsu, Mie 514-8507, JapanDepartment of Immunology, Mie University Faculty and Graduate School of Medicine, Edobashi 2-174, Tsu, Mie 514-8507, JapanDepartment of Gastroenterology and Hepatology, Mie University Faculty and Graduate School of Medicine, Edobashi 2-174, Tsu, Mie 514-8507, JapanDepartment of Gastroenterology and Hepatology, Mie University Faculty and Graduate School of Medicine, Edobashi 2-174, Tsu, Mie 514-8507, JapanDepartment of Gastroenterology and Hepatology, Mie University Faculty and Graduate School of Medicine, Edobashi 2-174, Tsu, Mie 514-8507, JapanDepartment of Endoscopic Medicine, Mie University and Graduate School of Medicine, Edobashi 2-174, Tsu, Mie 514-8507, JapanDepartment of Endoscopic Medicine, Mie University and Graduate School of Medicine, Edobashi 2-174, Tsu, Mie 514-8507, JapanDepartment of Immunology, Mie University Faculty and Graduate School of Medicine, Edobashi 2-174, Tsu, Mie 514-8507, JapanDepartment of Gastroenterology and Hepatology, Mie University Faculty and Graduate School of Medicine, Edobashi 2-174, Tsu, Mie 514-8507, JapanBackground: The role of <i>Helicobacter pylori</i> in the pathogenesis of reflux esophagitis is controversial. This study investigated the frequency of reflux esophagitis before and after <i>H. pylori</i> eradication in patients having endoscopic submucosal dissection for early gastric cancer. Methods: This study included 160 patients that fulfilled the study’s criteria. Endoscopy was performed before and after <i>H. pylori</i> eradication, and reflux esophagitis was evaluated during the follow-up period. Results: Seropositivity for <i>H. pylori</i> in patients with early gastric cancer was 68.8%, 101 of them received eradication therapy. During the follow-up period, the incidence of reflux esophagitis increased from 3.1% to 18.8% in the successful eradication group but no case of reflux esophagitis was observed in the failed eradication group. The univariate and multivariate analyses showed a significant correlation between successful <i>H. pylori</i> eradication rate and the development of reflux esophagitis. Conclusions: This study demonstrated that a successful <i>H. pylori</i> eradication therapy is a risk factor for newly developed reflux esophagitis in patients with endoscopic submucosal dissection for early gastric cancer.https://www.mdpi.com/2072-6694/13/8/1779<i>Helicobacter pylori</i>reflux esophagitisearly gastric cancergastritisJapanese population |
spellingShingle | Masaki Katsurahara Ichiro Imoto Yuhei Umeda Hiroshi Miura Junya Tsuboi Reiko Yamada Taro Yasuma Misaki Nakamura Yasuhiko Hamada Hiroyuki Inoue Kyosuke Tanaka Noriyuki Horiki Esteban C. Gabazza Yoshiyuki Takei Increased Reflux Esophagitis after <i>Helicobacter pylori</i> Eradication Therapy in Cases Undergoing Endoscopic Submucosal Dissection for Early Gastric Cancer Cancers <i>Helicobacter pylori</i> reflux esophagitis early gastric cancer gastritis Japanese population |
title | Increased Reflux Esophagitis after <i>Helicobacter pylori</i> Eradication Therapy in Cases Undergoing Endoscopic Submucosal Dissection for Early Gastric Cancer |
title_full | Increased Reflux Esophagitis after <i>Helicobacter pylori</i> Eradication Therapy in Cases Undergoing Endoscopic Submucosal Dissection for Early Gastric Cancer |
title_fullStr | Increased Reflux Esophagitis after <i>Helicobacter pylori</i> Eradication Therapy in Cases Undergoing Endoscopic Submucosal Dissection for Early Gastric Cancer |
title_full_unstemmed | Increased Reflux Esophagitis after <i>Helicobacter pylori</i> Eradication Therapy in Cases Undergoing Endoscopic Submucosal Dissection for Early Gastric Cancer |
title_short | Increased Reflux Esophagitis after <i>Helicobacter pylori</i> Eradication Therapy in Cases Undergoing Endoscopic Submucosal Dissection for Early Gastric Cancer |
title_sort | increased reflux esophagitis after i helicobacter pylori i eradication therapy in cases undergoing endoscopic submucosal dissection for early gastric cancer |
topic | <i>Helicobacter pylori</i> reflux esophagitis early gastric cancer gastritis Japanese population |
url | https://www.mdpi.com/2072-6694/13/8/1779 |
work_keys_str_mv | AT masakikatsurahara increasedrefluxesophagitisafterihelicobacterpyloriieradicationtherapyincasesundergoingendoscopicsubmucosaldissectionforearlygastriccancer AT ichiroimoto increasedrefluxesophagitisafterihelicobacterpyloriieradicationtherapyincasesundergoingendoscopicsubmucosaldissectionforearlygastriccancer AT yuheiumeda increasedrefluxesophagitisafterihelicobacterpyloriieradicationtherapyincasesundergoingendoscopicsubmucosaldissectionforearlygastriccancer AT hiroshimiura increasedrefluxesophagitisafterihelicobacterpyloriieradicationtherapyincasesundergoingendoscopicsubmucosaldissectionforearlygastriccancer AT junyatsuboi increasedrefluxesophagitisafterihelicobacterpyloriieradicationtherapyincasesundergoingendoscopicsubmucosaldissectionforearlygastriccancer AT reikoyamada increasedrefluxesophagitisafterihelicobacterpyloriieradicationtherapyincasesundergoingendoscopicsubmucosaldissectionforearlygastriccancer AT taroyasuma increasedrefluxesophagitisafterihelicobacterpyloriieradicationtherapyincasesundergoingendoscopicsubmucosaldissectionforearlygastriccancer AT misakinakamura increasedrefluxesophagitisafterihelicobacterpyloriieradicationtherapyincasesundergoingendoscopicsubmucosaldissectionforearlygastriccancer AT yasuhikohamada increasedrefluxesophagitisafterihelicobacterpyloriieradicationtherapyincasesundergoingendoscopicsubmucosaldissectionforearlygastriccancer AT hiroyukiinoue increasedrefluxesophagitisafterihelicobacterpyloriieradicationtherapyincasesundergoingendoscopicsubmucosaldissectionforearlygastriccancer AT kyosuketanaka increasedrefluxesophagitisafterihelicobacterpyloriieradicationtherapyincasesundergoingendoscopicsubmucosaldissectionforearlygastriccancer AT noriyukihoriki increasedrefluxesophagitisafterihelicobacterpyloriieradicationtherapyincasesundergoingendoscopicsubmucosaldissectionforearlygastriccancer AT estebancgabazza increasedrefluxesophagitisafterihelicobacterpyloriieradicationtherapyincasesundergoingendoscopicsubmucosaldissectionforearlygastriccancer AT yoshiyukitakei increasedrefluxesophagitisafterihelicobacterpyloriieradicationtherapyincasesundergoingendoscopicsubmucosaldissectionforearlygastriccancer |