Utility of cerebral perfusion SPECT in the diagnosis of mild cognitive impairment
Background: Mild cognitive impairment (MCI), an intermediate state between normal ageing and dementia, is characterized by acquired cognitive deficits, without significant decline in functional activities of daily living. Functional imaging techniques have demonstrated regional abnormalities in brai...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2012-01-01
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| Series: | Current Medicine Research and Practice |
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| Online Access: | http://www.cmrpjournal.org/article.asp?issn=2352-0817;year=2012;volume=2;issue=4;spage=197;epage=204;aulast=Verma |
| _version_ | 1811180233068380160 |
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| author | Ritu Verma Rajeev Ranjan Promila Pankaj C S Aggarwal Vineet Pant Anjali Jain |
| author_facet | Ritu Verma Rajeev Ranjan Promila Pankaj C S Aggarwal Vineet Pant Anjali Jain |
| author_sort | Ritu Verma |
| collection | DOAJ |
| description | Background: Mild cognitive impairment (MCI), an intermediate state between normal ageing and dementia, is characterized by acquired cognitive deficits, without significant decline in functional activities of daily living. Functional imaging techniques have demonstrated regional abnormalities in brain metabolism/brain perfusion in patients with MCI. Objectives: We assessed changes in regional cerebral blood flow (rCBF) in patients presenting with MCI using99mTc ECD-SPECT. Materials and Methods: This study included 35 subjects with clinical suspicion of MCI and 20 age-matched controls. They were evaluated clinically with complete neuropsychological assessment. SPECT examination was also done using99mTC-ECD with a dual-head gamma camera equipped with a fan beam collimator. The resulting images were reconstructed and evaluated both visually and by semi-quantitative assessment. The cortical regions were compared with the cerebellum and cortical/ cerebellar ratios were calculated. Results: A significant reduction in cerebral cortical perfusion was found in the prefrontal, parietal and temporal cortices of the subjects with MCI, with preserved perfusion in the superior frontal, sensory-motor, occipital, thalami, basal ganglia and the cerebellum. On semi-quantitative assessment, this hypoperfusion was found to be more significant on the left side. No statistically significant perfusion abnormality was noted in the control group. Conclusion: Assessment of cerebral perfusion SPECT in patients with clinical suspicion of MCI would not only be helpful in detecting areas of hypoperfusion (thereby aiding the clinical diagnosis), but would also serve as a baseline study for future comparisons and evaluation of disease progression. |
| first_indexed | 2024-04-11T06:46:53Z |
| format | Article |
| id | doaj.art-53e0a630fdb4422fa9ec626ace00d85b |
| institution | Directory Open Access Journal |
| issn | 2352-0817 2352-0825 |
| language | English |
| last_indexed | 2024-04-11T06:46:53Z |
| publishDate | 2012-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Current Medicine Research and Practice |
| spelling | doaj.art-53e0a630fdb4422fa9ec626ace00d85b2022-12-22T04:39:19ZengWolters Kluwer Medknow PublicationsCurrent Medicine Research and Practice2352-08172352-08252012-01-0124197204Utility of cerebral perfusion SPECT in the diagnosis of mild cognitive impairmentRitu VermaRajeev RanjanPromila PankajC S AggarwalVineet PantAnjali JainBackground: Mild cognitive impairment (MCI), an intermediate state between normal ageing and dementia, is characterized by acquired cognitive deficits, without significant decline in functional activities of daily living. Functional imaging techniques have demonstrated regional abnormalities in brain metabolism/brain perfusion in patients with MCI. Objectives: We assessed changes in regional cerebral blood flow (rCBF) in patients presenting with MCI using99mTc ECD-SPECT. Materials and Methods: This study included 35 subjects with clinical suspicion of MCI and 20 age-matched controls. They were evaluated clinically with complete neuropsychological assessment. SPECT examination was also done using99mTC-ECD with a dual-head gamma camera equipped with a fan beam collimator. The resulting images were reconstructed and evaluated both visually and by semi-quantitative assessment. The cortical regions were compared with the cerebellum and cortical/ cerebellar ratios were calculated. Results: A significant reduction in cerebral cortical perfusion was found in the prefrontal, parietal and temporal cortices of the subjects with MCI, with preserved perfusion in the superior frontal, sensory-motor, occipital, thalami, basal ganglia and the cerebellum. On semi-quantitative assessment, this hypoperfusion was found to be more significant on the left side. No statistically significant perfusion abnormality was noted in the control group. Conclusion: Assessment of cerebral perfusion SPECT in patients with clinical suspicion of MCI would not only be helpful in detecting areas of hypoperfusion (thereby aiding the clinical diagnosis), but would also serve as a baseline study for future comparisons and evaluation of disease progression.http://www.cmrpjournal.org/article.asp?issn=2352-0817;year=2012;volume=2;issue=4;spage=197;epage=204;aulast=Vermamild cognitive impairment (mci)99mtc ecd-spectcortical/cerebellar ratio |
| spellingShingle | Ritu Verma Rajeev Ranjan Promila Pankaj C S Aggarwal Vineet Pant Anjali Jain Utility of cerebral perfusion SPECT in the diagnosis of mild cognitive impairment Current Medicine Research and Practice mild cognitive impairment (mci) 99mtc ecd-spect cortical/cerebellar ratio |
| title | Utility of cerebral perfusion SPECT in the diagnosis of mild cognitive impairment |
| title_full | Utility of cerebral perfusion SPECT in the diagnosis of mild cognitive impairment |
| title_fullStr | Utility of cerebral perfusion SPECT in the diagnosis of mild cognitive impairment |
| title_full_unstemmed | Utility of cerebral perfusion SPECT in the diagnosis of mild cognitive impairment |
| title_short | Utility of cerebral perfusion SPECT in the diagnosis of mild cognitive impairment |
| title_sort | utility of cerebral perfusion spect in the diagnosis of mild cognitive impairment |
| topic | mild cognitive impairment (mci) 99mtc ecd-spect cortical/cerebellar ratio |
| url | http://www.cmrpjournal.org/article.asp?issn=2352-0817;year=2012;volume=2;issue=4;spage=197;epage=204;aulast=Verma |
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