Rathke's cleft cyst associated with pituitary granulomatosis with polyangiitis: An unusual combination of hypothalamus-pituitary region pathologies
The authors present an unusual case of a patient suffering from visual deficit due to pituitary granulomatosis with polyangiitis (GPA) associated with Rathke's cleft cyst (RCC). The patient was referred to our Neurosurgery Department presenting right eye amaurosis, third cranial nerve palsy, an...
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| Format: | Article |
| Language: | English |
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Elsevier
2018-02-01
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| Series: | Radiology Case Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1930043317300432 |
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| author | Riccardo Draghi, MD Giovanna Mantovani, MD, PhD Letterio Runza, MD Giorgio Carrabba, MD Nicola Fusco, MD Paolo Rampini, MD Antonella Costa, MD Marco Locatelli, MD, PhD |
| author_facet | Riccardo Draghi, MD Giovanna Mantovani, MD, PhD Letterio Runza, MD Giorgio Carrabba, MD Nicola Fusco, MD Paolo Rampini, MD Antonella Costa, MD Marco Locatelli, MD, PhD |
| author_sort | Riccardo Draghi, MD |
| collection | DOAJ |
| description | The authors present an unusual case of a patient suffering from visual deficit due to pituitary granulomatosis with polyangiitis (GPA) associated with Rathke's cleft cyst (RCC). The patient was referred to our Neurosurgery Department presenting right eye amaurosis, third cranial nerve palsy, and left temporal hemianopsia. Magnetic resonance imaging documented a sellar or suprasellar lesion with solid and cystic components. The dura mater of the skull base was also strongly enhanced. The patient underwent surgery. Histologic examination revealed RCC associated with pituitary GPA. To our knowledge, this is the first reported case of concomitant pituitary GPA and RCC. Pituitary involvement in GPA is rare, usually diagnosed in hormonal dysfunctions. The patient in case first presented optic chiasm compression, probably due to inflammation of both the pituitary gland and the previously asymptomatic RCC. We focus on the symptoms that led us to diagnose GPA pituitary involvement and on the peculiar and unusual Magnetic resonance imaging of the case presented. |
| first_indexed | 2024-12-10T12:25:47Z |
| format | Article |
| id | doaj.art-53e0dcd390c9441381a091baf4d9107d |
| institution | Directory Open Access Journal |
| issn | 1930-0433 |
| language | English |
| last_indexed | 2024-12-10T12:25:47Z |
| publishDate | 2018-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Radiology Case Reports |
| spelling | doaj.art-53e0dcd390c9441381a091baf4d9107d2022-12-22T01:48:59ZengElsevierRadiology Case Reports1930-04332018-02-0113123323610.1016/j.radcr.2017.09.018Rathke's cleft cyst associated with pituitary granulomatosis with polyangiitis: An unusual combination of hypothalamus-pituitary region pathologiesRiccardo Draghi, MD0Giovanna Mantovani, MD, PhD1Letterio Runza, MD2Giorgio Carrabba, MD3Nicola Fusco, MD4Paolo Rampini, MD5Antonella Costa, MD6Marco Locatelli, MD, PhD7Neurosurgery Unit, Department of Medical and Surgical Pathophysiology of Organs and Transplantation, Università degli Studi di Milano, Milan, ItalyEndocrinology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, ItalyDivision of Pathology, Fondazione IRCCS “Ca' Granda” Ospedale Maggiore Policlinico, Milan, ItalyDepartment of Neurosurgery, Fondazione IRCCS “Ca' Granda” Ospedale Maggiore Policlinico, Milan, ItalyDivision of Pathology, Fondazione IRCCS “Ca' Granda” Ospedale Maggiore Policlinico, Milan, ItalyDepartment of Neurosurgery, Fondazione IRCCS “Ca' Granda” Ospedale Maggiore Policlinico, Milan, ItalyNeuroradiology, Fondazione IRCCS “Ca' Granda” Ospedale Maggiore Policlinico, Milan, ItalyDepartment of Neurosurgery, Fondazione IRCCS “Ca' Granda” Ospedale Maggiore Policlinico, Milan, ItalyThe authors present an unusual case of a patient suffering from visual deficit due to pituitary granulomatosis with polyangiitis (GPA) associated with Rathke's cleft cyst (RCC). The patient was referred to our Neurosurgery Department presenting right eye amaurosis, third cranial nerve palsy, and left temporal hemianopsia. Magnetic resonance imaging documented a sellar or suprasellar lesion with solid and cystic components. The dura mater of the skull base was also strongly enhanced. The patient underwent surgery. Histologic examination revealed RCC associated with pituitary GPA. To our knowledge, this is the first reported case of concomitant pituitary GPA and RCC. Pituitary involvement in GPA is rare, usually diagnosed in hormonal dysfunctions. The patient in case first presented optic chiasm compression, probably due to inflammation of both the pituitary gland and the previously asymptomatic RCC. We focus on the symptoms that led us to diagnose GPA pituitary involvement and on the peculiar and unusual Magnetic resonance imaging of the case presented.http://www.sciencedirect.com/science/article/pii/S1930043317300432Rathke's cleft cystGranulomatosis with polyangiitisPituitary gland |
| spellingShingle | Riccardo Draghi, MD Giovanna Mantovani, MD, PhD Letterio Runza, MD Giorgio Carrabba, MD Nicola Fusco, MD Paolo Rampini, MD Antonella Costa, MD Marco Locatelli, MD, PhD Rathke's cleft cyst associated with pituitary granulomatosis with polyangiitis: An unusual combination of hypothalamus-pituitary region pathologies Radiology Case Reports Rathke's cleft cyst Granulomatosis with polyangiitis Pituitary gland |
| title | Rathke's cleft cyst associated with pituitary granulomatosis with polyangiitis: An unusual combination of hypothalamus-pituitary region pathologies |
| title_full | Rathke's cleft cyst associated with pituitary granulomatosis with polyangiitis: An unusual combination of hypothalamus-pituitary region pathologies |
| title_fullStr | Rathke's cleft cyst associated with pituitary granulomatosis with polyangiitis: An unusual combination of hypothalamus-pituitary region pathologies |
| title_full_unstemmed | Rathke's cleft cyst associated with pituitary granulomatosis with polyangiitis: An unusual combination of hypothalamus-pituitary region pathologies |
| title_short | Rathke's cleft cyst associated with pituitary granulomatosis with polyangiitis: An unusual combination of hypothalamus-pituitary region pathologies |
| title_sort | rathke s cleft cyst associated with pituitary granulomatosis with polyangiitis an unusual combination of hypothalamus pituitary region pathologies |
| topic | Rathke's cleft cyst Granulomatosis with polyangiitis Pituitary gland |
| url | http://www.sciencedirect.com/science/article/pii/S1930043317300432 |
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