Prefrontal inhibition drives formation and dynamic expression of probabilistic Pavlovian fear conditioning
Summary: The association between cause and effect is usually probabilistic. Memories triggered by ambiguous cues may be altered or biased into a more negative perception in psychiatric diseases. Understanding the formation and modulation of this probabilistic association is important for revealing t...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2021-08-01
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| Series: | Cell Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124721009311 |
| _version_ | 1818607912604401664 |
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| author | Rongzhen Yan Tianyu Wang Xiaoyan Ma Xinyang Zhang Rui Zheng Qiang Zhou |
| author_facet | Rongzhen Yan Tianyu Wang Xiaoyan Ma Xinyang Zhang Rui Zheng Qiang Zhou |
| author_sort | Rongzhen Yan |
| collection | DOAJ |
| description | Summary: The association between cause and effect is usually probabilistic. Memories triggered by ambiguous cues may be altered or biased into a more negative perception in psychiatric diseases. Understanding the formation and modulation of this probabilistic association is important for revealing the nature of aversive memory and alterations in brain diseases. We found that 50% conditioned and unconditioned stimuli (CS-US) association during Pavlovian fear conditioning results in reduced fear responses and neural spiking in the dorsomedial prefrontal cortex (dmPFC) due to enhanced inhibition from dmPFC parvalbumin (PV) neurons. Formation of probabilistic memory is associated with increased synaptic inputs to PV-neurons and requires activation of ventral hippocampus, which detects CS-US mismatch during conditioning. Stress prior to conditioning impairs the formation of probabilistic memory by abolishing PV-neuronal plasticity, while stress prior to memory retrieval reverts enhanced PV-neuron activity. In conclusion, PV-neurons tailor learned responses to fit brain state at the moment of retrieval. |
| first_indexed | 2024-12-16T14:34:17Z |
| format | Article |
| id | doaj.art-53e17602d187403b84642633019efdf2 |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-12-16T14:34:17Z |
| publishDate | 2021-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-53e17602d187403b84642633019efdf22022-12-21T22:28:09ZengElsevierCell Reports2211-12472021-08-01366109503Prefrontal inhibition drives formation and dynamic expression of probabilistic Pavlovian fear conditioningRongzhen Yan0Tianyu Wang1Xiaoyan Ma2Xinyang Zhang3Rui Zheng4Qiang Zhou5State Key Laboratory of Chemical Oncogenomics, Guangdong Provincial Key Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School, Shenzhen 518055, PRCState Key Laboratory of Chemical Oncogenomics, Guangdong Provincial Key Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School, Shenzhen 518055, PRCState Key Laboratory of Chemical Oncogenomics, Guangdong Provincial Key Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School, Shenzhen 518055, PRCState Key Laboratory of Chemical Oncogenomics, Guangdong Provincial Key Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School, Shenzhen 518055, PRCState Key Laboratory of Chemical Oncogenomics, Guangdong Provincial Key Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School, Shenzhen 518055, PRCState Key Laboratory of Chemical Oncogenomics, Guangdong Provincial Key Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School, Shenzhen 518055, PRC; Corresponding authorSummary: The association between cause and effect is usually probabilistic. Memories triggered by ambiguous cues may be altered or biased into a more negative perception in psychiatric diseases. Understanding the formation and modulation of this probabilistic association is important for revealing the nature of aversive memory and alterations in brain diseases. We found that 50% conditioned and unconditioned stimuli (CS-US) association during Pavlovian fear conditioning results in reduced fear responses and neural spiking in the dorsomedial prefrontal cortex (dmPFC) due to enhanced inhibition from dmPFC parvalbumin (PV) neurons. Formation of probabilistic memory is associated with increased synaptic inputs to PV-neurons and requires activation of ventral hippocampus, which detects CS-US mismatch during conditioning. Stress prior to conditioning impairs the formation of probabilistic memory by abolishing PV-neuronal plasticity, while stress prior to memory retrieval reverts enhanced PV-neuron activity. In conclusion, PV-neurons tailor learned responses to fit brain state at the moment of retrieval.http://www.sciencedirect.com/science/article/pii/S2211124721009311prefrontal cortexparvalbumin neuronsplasticityprobabilistic fear conditioningstress |
| spellingShingle | Rongzhen Yan Tianyu Wang Xiaoyan Ma Xinyang Zhang Rui Zheng Qiang Zhou Prefrontal inhibition drives formation and dynamic expression of probabilistic Pavlovian fear conditioning Cell Reports prefrontal cortex parvalbumin neurons plasticity probabilistic fear conditioning stress |
| title | Prefrontal inhibition drives formation and dynamic expression of probabilistic Pavlovian fear conditioning |
| title_full | Prefrontal inhibition drives formation and dynamic expression of probabilistic Pavlovian fear conditioning |
| title_fullStr | Prefrontal inhibition drives formation and dynamic expression of probabilistic Pavlovian fear conditioning |
| title_full_unstemmed | Prefrontal inhibition drives formation and dynamic expression of probabilistic Pavlovian fear conditioning |
| title_short | Prefrontal inhibition drives formation and dynamic expression of probabilistic Pavlovian fear conditioning |
| title_sort | prefrontal inhibition drives formation and dynamic expression of probabilistic pavlovian fear conditioning |
| topic | prefrontal cortex parvalbumin neurons plasticity probabilistic fear conditioning stress |
| url | http://www.sciencedirect.com/science/article/pii/S2211124721009311 |
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