The applications of animal models in phage therapy: An update
The rapid increase in antibiotic resistance presents a dire situation necessitating the need for alternative therapeutic agents. Among the current alternative therapies, phage therapy (PT) is promising. This review extensively summarizes preclinical PT approaches in various in-vivo models. PT has be...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2023-01-01
|
| Series: | Human Vaccines & Immunotherapeutics |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/21645515.2023.2175519 |
| _version_ | 1797673098916397056 |
|---|---|
| author | Fazal Mehmood Khan Prasanth Manohar Vijay Singh Gondil Nancy Mehra Greater Kayode Oyejobi Nelson Odiwuor Tauseef Ahmad Guangtao Huang |
| author_facet | Fazal Mehmood Khan Prasanth Manohar Vijay Singh Gondil Nancy Mehra Greater Kayode Oyejobi Nelson Odiwuor Tauseef Ahmad Guangtao Huang |
| author_sort | Fazal Mehmood Khan |
| collection | DOAJ |
| description | The rapid increase in antibiotic resistance presents a dire situation necessitating the need for alternative therapeutic agents. Among the current alternative therapies, phage therapy (PT) is promising. This review extensively summarizes preclinical PT approaches in various in-vivo models. PT has been evaluated in several recent clinical trials. However, there are still several unanswered concerns due to a lack of appropriate regulation and pharmacokinetic data regarding the application of phages in human therapeutic procedures. In this review, we also presented the current state of PT and considered how animal models can be used to adapt these therapies for humans. The development of realistic solutions to circumvent these constraints is critical for advancing this technology. |
| first_indexed | 2024-03-11T21:39:41Z |
| format | Article |
| id | doaj.art-53e1b30658e94010865fcbf7eae7e9ea |
| institution | Directory Open Access Journal |
| issn | 2164-5515 2164-554X |
| language | English |
| last_indexed | 2024-03-11T21:39:41Z |
| publishDate | 2023-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Human Vaccines & Immunotherapeutics |
| spelling | doaj.art-53e1b30658e94010865fcbf7eae7e9ea2023-09-26T13:25:48ZengTaylor & Francis GroupHuman Vaccines & Immunotherapeutics2164-55152164-554X2023-01-0119110.1080/21645515.2023.21755192175519The applications of animal models in phage therapy: An updateFazal Mehmood Khan0Prasanth Manohar1Vijay Singh Gondil2Nancy Mehra3Greater Kayode Oyejobi4Nelson Odiwuor5Tauseef Ahmad6Guangtao Huang7Shenzhen UniversityVellore Institute of TechnologyChinese Academy of SciencesPostgraduate Institute of Medical Education and ResearchChinese Academy of SciencesChinese Academy of SciencesSoutheast UniversityThe First Affiliated Hospital of Shenzhen UniversityThe rapid increase in antibiotic resistance presents a dire situation necessitating the need for alternative therapeutic agents. Among the current alternative therapies, phage therapy (PT) is promising. This review extensively summarizes preclinical PT approaches in various in-vivo models. PT has been evaluated in several recent clinical trials. However, there are still several unanswered concerns due to a lack of appropriate regulation and pharmacokinetic data regarding the application of phages in human therapeutic procedures. In this review, we also presented the current state of PT and considered how animal models can be used to adapt these therapies for humans. The development of realistic solutions to circumvent these constraints is critical for advancing this technology.http://dx.doi.org/10.1080/21645515.2023.2175519phage therapyanimal infection modelantimicrobial resistanceeskape pathogensendolysin |
| spellingShingle | Fazal Mehmood Khan Prasanth Manohar Vijay Singh Gondil Nancy Mehra Greater Kayode Oyejobi Nelson Odiwuor Tauseef Ahmad Guangtao Huang The applications of animal models in phage therapy: An update Human Vaccines & Immunotherapeutics phage therapy animal infection model antimicrobial resistance eskape pathogens endolysin |
| title | The applications of animal models in phage therapy: An update |
| title_full | The applications of animal models in phage therapy: An update |
| title_fullStr | The applications of animal models in phage therapy: An update |
| title_full_unstemmed | The applications of animal models in phage therapy: An update |
| title_short | The applications of animal models in phage therapy: An update |
| title_sort | applications of animal models in phage therapy an update |
| topic | phage therapy animal infection model antimicrobial resistance eskape pathogens endolysin |
| url | http://dx.doi.org/10.1080/21645515.2023.2175519 |
| work_keys_str_mv | AT fazalmehmoodkhan theapplicationsofanimalmodelsinphagetherapyanupdate AT prasanthmanohar theapplicationsofanimalmodelsinphagetherapyanupdate AT vijaysinghgondil theapplicationsofanimalmodelsinphagetherapyanupdate AT nancymehra theapplicationsofanimalmodelsinphagetherapyanupdate AT greaterkayodeoyejobi theapplicationsofanimalmodelsinphagetherapyanupdate AT nelsonodiwuor theapplicationsofanimalmodelsinphagetherapyanupdate AT tauseefahmad theapplicationsofanimalmodelsinphagetherapyanupdate AT guangtaohuang theapplicationsofanimalmodelsinphagetherapyanupdate AT fazalmehmoodkhan applicationsofanimalmodelsinphagetherapyanupdate AT prasanthmanohar applicationsofanimalmodelsinphagetherapyanupdate AT vijaysinghgondil applicationsofanimalmodelsinphagetherapyanupdate AT nancymehra applicationsofanimalmodelsinphagetherapyanupdate AT greaterkayodeoyejobi applicationsofanimalmodelsinphagetherapyanupdate AT nelsonodiwuor applicationsofanimalmodelsinphagetherapyanupdate AT tauseefahmad applicationsofanimalmodelsinphagetherapyanupdate AT guangtaohuang applicationsofanimalmodelsinphagetherapyanupdate |