Disrupted Topological Organization in White Matter Networks in Unilateral Sudden Sensorineural Hearing Loss
Sudden sensorineural hearing loss (SSNHL) is a sudden-onset hearing impairment that rapidly develops within 72 h and is mostly unilateral. Only a few patients can be identified with a defined cause by routine clinical examinations. Recently, some studies have shown that unilateral SSNHL is associate...
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Frontiers Media S.A.
2021-07-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2021.666651/full |
| _version_ | 1818922430516690944 |
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| author | Yan Zou Yan Zou Hui Ma Hui Ma Bo Liu Dan Li Dingxi Liu Dingxi Liu Xinrong Wang Siqi Wang Siqi Wang Wenliang Fan Wenliang Fan Ping Han Ping Han |
| author_facet | Yan Zou Yan Zou Hui Ma Hui Ma Bo Liu Dan Li Dingxi Liu Dingxi Liu Xinrong Wang Siqi Wang Siqi Wang Wenliang Fan Wenliang Fan Ping Han Ping Han |
| author_sort | Yan Zou |
| collection | DOAJ |
| description | Sudden sensorineural hearing loss (SSNHL) is a sudden-onset hearing impairment that rapidly develops within 72 h and is mostly unilateral. Only a few patients can be identified with a defined cause by routine clinical examinations. Recently, some studies have shown that unilateral SSNHL is associated with alterations in the central nervous system. However, little is known about the topological organization of white matter (WM) networks in unilateral SSNHL patients in the acute phase. In this study, 145 patients with SSNHL and 91 age-, gender-, and education-matched healthy controls were evaluated using diffusion tensor imaging (DTI) and graph theoretical approaches. The topological properties of WM networks, including global and nodal parameters, were investigated. At the global level, SSNHL patients displayed decreased clustering coefficient, local efficiency, global efficiency, normalized clustering coefficient, normalized characteristic path length, and small-worldness and increased characteristic path length (p < 0.05) compared with healthy controls. At the nodal level, altered nodal centralities in brain regions involved the auditory network, visual network, attention network, default mode network (DMN), sensorimotor network, and subcortical network (p < 0.05, Bonferroni corrected). These findings indicate a shift of the WM network topology in SSNHL patients toward randomization, which is characterized by decreased global network integration and segregation and is reflected by decreased global connectivity and altered nodal centralities. This study could help us understand the potential pathophysiology of unilateral SSNHL. |
| first_indexed | 2024-12-20T01:53:25Z |
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| id | doaj.art-53e2f37b019d4167853c85f107cc53ac |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-12-20T01:53:25Z |
| publishDate | 2021-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-53e2f37b019d4167853c85f107cc53ac2022-12-21T19:57:35ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2021-07-011510.3389/fnins.2021.666651666651Disrupted Topological Organization in White Matter Networks in Unilateral Sudden Sensorineural Hearing LossYan Zou0Yan Zou1Hui Ma2Hui Ma3Bo Liu4Dan Li5Dingxi Liu6Dingxi Liu7Xinrong Wang8Siqi Wang9Siqi Wang10Wenliang Fan11Wenliang Fan12Ping Han13Ping Han14Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaHubei Key Laboratory of Molecular Imaging, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaHubei Key Laboratory of Molecular Imaging, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaHubei Key Laboratory of Molecular Imaging, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaGE Healthcare, Shanghai, ChinaDepartment of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaHubei Key Laboratory of Molecular Imaging, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaHubei Key Laboratory of Molecular Imaging, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaHubei Key Laboratory of Molecular Imaging, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaSudden sensorineural hearing loss (SSNHL) is a sudden-onset hearing impairment that rapidly develops within 72 h and is mostly unilateral. Only a few patients can be identified with a defined cause by routine clinical examinations. Recently, some studies have shown that unilateral SSNHL is associated with alterations in the central nervous system. However, little is known about the topological organization of white matter (WM) networks in unilateral SSNHL patients in the acute phase. In this study, 145 patients with SSNHL and 91 age-, gender-, and education-matched healthy controls were evaluated using diffusion tensor imaging (DTI) and graph theoretical approaches. The topological properties of WM networks, including global and nodal parameters, were investigated. At the global level, SSNHL patients displayed decreased clustering coefficient, local efficiency, global efficiency, normalized clustering coefficient, normalized characteristic path length, and small-worldness and increased characteristic path length (p < 0.05) compared with healthy controls. At the nodal level, altered nodal centralities in brain regions involved the auditory network, visual network, attention network, default mode network (DMN), sensorimotor network, and subcortical network (p < 0.05, Bonferroni corrected). These findings indicate a shift of the WM network topology in SSNHL patients toward randomization, which is characterized by decreased global network integration and segregation and is reflected by decreased global connectivity and altered nodal centralities. This study could help us understand the potential pathophysiology of unilateral SSNHL.https://www.frontiersin.org/articles/10.3389/fnins.2021.666651/fulldiffusional tensor imagingdeterministic tractographygraph theorysmall-worldnessunilateral sudden sensorineural hearing loss |
| spellingShingle | Yan Zou Yan Zou Hui Ma Hui Ma Bo Liu Dan Li Dingxi Liu Dingxi Liu Xinrong Wang Siqi Wang Siqi Wang Wenliang Fan Wenliang Fan Ping Han Ping Han Disrupted Topological Organization in White Matter Networks in Unilateral Sudden Sensorineural Hearing Loss Frontiers in Neuroscience diffusional tensor imaging deterministic tractography graph theory small-worldness unilateral sudden sensorineural hearing loss |
| title | Disrupted Topological Organization in White Matter Networks in Unilateral Sudden Sensorineural Hearing Loss |
| title_full | Disrupted Topological Organization in White Matter Networks in Unilateral Sudden Sensorineural Hearing Loss |
| title_fullStr | Disrupted Topological Organization in White Matter Networks in Unilateral Sudden Sensorineural Hearing Loss |
| title_full_unstemmed | Disrupted Topological Organization in White Matter Networks in Unilateral Sudden Sensorineural Hearing Loss |
| title_short | Disrupted Topological Organization in White Matter Networks in Unilateral Sudden Sensorineural Hearing Loss |
| title_sort | disrupted topological organization in white matter networks in unilateral sudden sensorineural hearing loss |
| topic | diffusional tensor imaging deterministic tractography graph theory small-worldness unilateral sudden sensorineural hearing loss |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2021.666651/full |
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