Association between Serum Visfatin, Oxidative Stress, Inflammation and Metabolic Syndrome in Obese Premenopausal Women
Introduction: Visfatin is an adipokine secreted by visceral fat tissue that has important effects on normal insulin secretion. An association has been found between visfatin and cardiovascular risk factors and obesity. Despite its role in the production of inflammatory cytokines, the role of visfati...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2019-02-01
|
| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/12652/37783_F(AC)_PF1(AJ_SHU)_PFA(AJ_SL)_PN(SL).pdf |
| _version_ | 1818967157719957504 |
|---|---|
| author | Moushira Erfan Zaki Sanaa Kamal Eman Youness Taghreed Shalabi Jihan Hussein Hanaa Reyad Walaa Basha |
| author_facet | Moushira Erfan Zaki Sanaa Kamal Eman Youness Taghreed Shalabi Jihan Hussein Hanaa Reyad Walaa Basha |
| author_sort | Moushira Erfan Zaki |
| collection | DOAJ |
| description | Introduction: Visfatin is an adipokine secreted by visceral fat tissue that has important effects on normal insulin secretion. An association has been found between visfatin and cardiovascular risk factors and obesity. Despite its role in the production of inflammatory cytokines, the role of visfatin in the Metabolic Syndrome (MS) is still a matter of debate. Aim: To evaluate the relation between serum visfatin levels, oxidative stress markers, Interleukin-6 (IL-6) and (MS) in premenopausal obese women. Materials and Methods: The study enrolled 150 premenopausal obese women and 80 age-matched healthy non-obese controls. Serum visfatin and IL-6 levels were measured by Enzyme linked Immunosorbent Assay (ELISA). Oxidative status was assessed by Total Antioxidant Capacity (TAC), Malondialdehyde (MDA), vitamins A and E and DNA damage was assessed by Comet assay. Results: Obese MS patients had significantly higher levels of visfatin, blood pressure levels, MDA and lower levels of TAC, A and E vitamins than the control group. DNA damage was significantly higher in obese women with MS and with a history of recurrent pre-eclampsia than controls. Multiple stepwise regressions analysis showed that log visfatin was positively correlated with MS components, IL-6 and MDA, serum lipids, DNA damage and negatively correlated with TAC and vitamin A and E. The log visfatin level of 1.56 had 76% sensitivity and 71% specificity for detecting MS in obese women with the area under the curve of 0.91. Conclusion: Significant positive correlations were observed between visfatin levels, oxidative and inflammatory markers with metabolic disturbance and pregnancy complications. These findings might emphasise the pathophysiological roles of these biomarkers in MS and pre-eclampsia and it may be useful to give treat to women in early pregnancy. |
| first_indexed | 2024-12-20T13:44:20Z |
| format | Article |
| id | doaj.art-53e5389f8fa94fd4ab707cc4235a38b9 |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-20T13:44:20Z |
| publishDate | 2019-02-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-53e5389f8fa94fd4ab707cc4235a38b92022-12-21T19:38:43ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2019-02-01132BC10BC1410.7860/JCDR/2019/37783.12652Association between Serum Visfatin, Oxidative Stress, Inflammation and Metabolic Syndrome in Obese Premenopausal WomenMoushira Erfan Zaki0Sanaa Kamal1Eman Youness2Taghreed Shalabi3Jihan Hussein4Hanaa Reyad5Walaa Basha6Professor, Department of Biological Anthropolgy, National Research Centre, Cairo, Egypt.Professor, Department of Biological Anthropolgy, National Research Centre, Cairo, Egypt.Professor, Department of Medical Biochemistry, National Research Centre, Cairo, Egypt.Professor, Department of Fetal Medicine, National Research Centre, Cairo, Egypt.Professor, Department of Medical Biochemistry, National Research Centre, Cairo, Egypt.Professor, Department of Biological Anthropology, National Research Centre, Cairo, Egypt.Professor, Department of Biological Anthropology, National Research Centre, Cairo, Egypt.Introduction: Visfatin is an adipokine secreted by visceral fat tissue that has important effects on normal insulin secretion. An association has been found between visfatin and cardiovascular risk factors and obesity. Despite its role in the production of inflammatory cytokines, the role of visfatin in the Metabolic Syndrome (MS) is still a matter of debate. Aim: To evaluate the relation between serum visfatin levels, oxidative stress markers, Interleukin-6 (IL-6) and (MS) in premenopausal obese women. Materials and Methods: The study enrolled 150 premenopausal obese women and 80 age-matched healthy non-obese controls. Serum visfatin and IL-6 levels were measured by Enzyme linked Immunosorbent Assay (ELISA). Oxidative status was assessed by Total Antioxidant Capacity (TAC), Malondialdehyde (MDA), vitamins A and E and DNA damage was assessed by Comet assay. Results: Obese MS patients had significantly higher levels of visfatin, blood pressure levels, MDA and lower levels of TAC, A and E vitamins than the control group. DNA damage was significantly higher in obese women with MS and with a history of recurrent pre-eclampsia than controls. Multiple stepwise regressions analysis showed that log visfatin was positively correlated with MS components, IL-6 and MDA, serum lipids, DNA damage and negatively correlated with TAC and vitamin A and E. The log visfatin level of 1.56 had 76% sensitivity and 71% specificity for detecting MS in obese women with the area under the curve of 0.91. Conclusion: Significant positive correlations were observed between visfatin levels, oxidative and inflammatory markers with metabolic disturbance and pregnancy complications. These findings might emphasise the pathophysiological roles of these biomarkers in MS and pre-eclampsia and it may be useful to give treat to women in early pregnancy.https://jcdr.net/articles/PDF/12652/37783_F(AC)_PF1(AJ_SHU)_PFA(AJ_SL)_PN(SL).pdfdna damageinflammatory markersobesityoxidative stress |
| spellingShingle | Moushira Erfan Zaki Sanaa Kamal Eman Youness Taghreed Shalabi Jihan Hussein Hanaa Reyad Walaa Basha Association between Serum Visfatin, Oxidative Stress, Inflammation and Metabolic Syndrome in Obese Premenopausal Women Journal of Clinical and Diagnostic Research dna damage inflammatory markers obesity oxidative stress |
| title | Association between Serum Visfatin, Oxidative Stress, Inflammation and Metabolic Syndrome in Obese Premenopausal Women |
| title_full | Association between Serum Visfatin, Oxidative Stress, Inflammation and Metabolic Syndrome in Obese Premenopausal Women |
| title_fullStr | Association between Serum Visfatin, Oxidative Stress, Inflammation and Metabolic Syndrome in Obese Premenopausal Women |
| title_full_unstemmed | Association between Serum Visfatin, Oxidative Stress, Inflammation and Metabolic Syndrome in Obese Premenopausal Women |
| title_short | Association between Serum Visfatin, Oxidative Stress, Inflammation and Metabolic Syndrome in Obese Premenopausal Women |
| title_sort | association between serum visfatin oxidative stress inflammation and metabolic syndrome in obese premenopausal women |
| topic | dna damage inflammatory markers obesity oxidative stress |
| url | https://jcdr.net/articles/PDF/12652/37783_F(AC)_PF1(AJ_SHU)_PFA(AJ_SL)_PN(SL).pdf |
| work_keys_str_mv | AT moushiraerfanzaki associationbetweenserumvisfatinoxidativestressinflammationandmetabolicsyndromeinobesepremenopausalwomen AT sanaakamal associationbetweenserumvisfatinoxidativestressinflammationandmetabolicsyndromeinobesepremenopausalwomen AT emanyouness associationbetweenserumvisfatinoxidativestressinflammationandmetabolicsyndromeinobesepremenopausalwomen AT taghreedshalabi associationbetweenserumvisfatinoxidativestressinflammationandmetabolicsyndromeinobesepremenopausalwomen AT jihanhussein associationbetweenserumvisfatinoxidativestressinflammationandmetabolicsyndromeinobesepremenopausalwomen AT hanaareyad associationbetweenserumvisfatinoxidativestressinflammationandmetabolicsyndromeinobesepremenopausalwomen AT walaabasha associationbetweenserumvisfatinoxidativestressinflammationandmetabolicsyndromeinobesepremenopausalwomen |