New Ionic Liquid Microemulsion-Mediated Synthesis of Silver Nanoparticles for Skin Bacterial Infection Treatments
This work reports a new approach for the synthesis of extremely small monodispersed silver nanoparticles (AgNPs) (2.9–1.5) by reduction of silver nitrate in a new series of benzyl alkyl imidazolium ionic liquids (BAIILs)-based microemulsions (3a–f) as media and stabilizing agents. Interestingly, AgN...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/12/2/247 |
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| author | Fayez Althobaiti Ola A. Abu Ali Islam Kamal Mohammad Y. Alfaifi Ali A. Shati Eman Fayad Serag Eldin I. Elbehairi Reda F. M. Elshaarawy W. Abd El-Fattah |
| author_facet | Fayez Althobaiti Ola A. Abu Ali Islam Kamal Mohammad Y. Alfaifi Ali A. Shati Eman Fayad Serag Eldin I. Elbehairi Reda F. M. Elshaarawy W. Abd El-Fattah |
| author_sort | Fayez Althobaiti |
| collection | DOAJ |
| description | This work reports a new approach for the synthesis of extremely small monodispersed silver nanoparticles (AgNPs) (2.9–1.5) by reduction of silver nitrate in a new series of benzyl alkyl imidazolium ionic liquids (BAIILs)-based microemulsions (3a–f) as media and stabilizing agents. Interestingly, AgNPs isolated from the IILMEs bearing the bulkiest substituents (<i>tert</i>-butyl and <i>n</i>-butyl) (3f) displayed almost no nanoparticle agglomeration. In an in vitro antibacterial test against ESKAPE pathogens, all AgNPs-BAIILs had potent antibiotic activity, as reflected by antibacterial efficiency indices. Furthermore, when compared to other nanoparticles, these were the most effective in preventing biofilm formation by the tested bacterial strains. Moreover, the MTT assay was used to determine the cytotoxicity of novel AgNPs-BAIILs on healthy human skin fibroblast (HSF) cell lines. The MTT assay revealed that novel AgNPs-BAIILs showed no significant toxic effects on the healthy cells. Thus, the novel AgNPs-BAIILs microemulsions could be used as safe antibiotics for skin bacterial infection treatments. AgNPs isolated from BAIIL (3c) was found to be the most effective antibiotic of the nanoparticles examined. |
| first_indexed | 2024-03-11T09:14:58Z |
| format | Article |
| id | doaj.art-53e5e87a8783479d9cdfd63a1463853e |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-11T09:14:58Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-53e5e87a8783479d9cdfd63a1463853e2023-11-16T18:42:16ZengMDPI AGAntibiotics2079-63822023-01-0112224710.3390/antibiotics12020247New Ionic Liquid Microemulsion-Mediated Synthesis of Silver Nanoparticles for Skin Bacterial Infection TreatmentsFayez Althobaiti0Ola A. Abu Ali1Islam Kamal2Mohammad Y. Alfaifi3Ali A. Shati4Eman Fayad5Serag Eldin I. Elbehairi6Reda F. M. Elshaarawy7W. Abd El-Fattah8Department of Biotechnology, Faculty of Sciences, Taif University, P.O. Box 11099, Taif 21944, Saudi ArabiaDepartment of Chemistry, College of Science, Taif University, P.O. Box 11099, Taif 21944, Saudi ArabiaDepartment of Pharmaceutics, Faculty of Pharmacy, Port Said University, Port Said 42526, EgyptBiology Department, Faculty of Science, King Khalid University, Abha 62529, Saudi ArabiaBiology Department, Faculty of Science, King Khalid University, Abha 62529, Saudi ArabiaDepartment of Biotechnology, Faculty of Sciences, Taif University, P.O. Box 11099, Taif 21944, Saudi ArabiaDepartment of Pharmaceutics, Faculty of Pharmacy, Port Said University, Port Said 42526, EgyptDepartment of Chemistry, Faculty of Science, Suez University, Suez 43533, EgyptChemistry Department, College of Science, IMSIU (Imam Mohammad Ibn Saud Islamic University), P.O. Box 5701, Riyadh 11432, Saudi ArabiaThis work reports a new approach for the synthesis of extremely small monodispersed silver nanoparticles (AgNPs) (2.9–1.5) by reduction of silver nitrate in a new series of benzyl alkyl imidazolium ionic liquids (BAIILs)-based microemulsions (3a–f) as media and stabilizing agents. Interestingly, AgNPs isolated from the IILMEs bearing the bulkiest substituents (<i>tert</i>-butyl and <i>n</i>-butyl) (3f) displayed almost no nanoparticle agglomeration. In an in vitro antibacterial test against ESKAPE pathogens, all AgNPs-BAIILs had potent antibiotic activity, as reflected by antibacterial efficiency indices. Furthermore, when compared to other nanoparticles, these were the most effective in preventing biofilm formation by the tested bacterial strains. Moreover, the MTT assay was used to determine the cytotoxicity of novel AgNPs-BAIILs on healthy human skin fibroblast (HSF) cell lines. The MTT assay revealed that novel AgNPs-BAIILs showed no significant toxic effects on the healthy cells. Thus, the novel AgNPs-BAIILs microemulsions could be used as safe antibiotics for skin bacterial infection treatments. AgNPs isolated from BAIIL (3c) was found to be the most effective antibiotic of the nanoparticles examined.https://www.mdpi.com/2079-6382/12/2/247benzyl alkyl imidazolium ionic liquidsmicroemulsionssilver nanoparticlesantibacterialskin bacterial infection treatments |
| spellingShingle | Fayez Althobaiti Ola A. Abu Ali Islam Kamal Mohammad Y. Alfaifi Ali A. Shati Eman Fayad Serag Eldin I. Elbehairi Reda F. M. Elshaarawy W. Abd El-Fattah New Ionic Liquid Microemulsion-Mediated Synthesis of Silver Nanoparticles for Skin Bacterial Infection Treatments Antibiotics benzyl alkyl imidazolium ionic liquids microemulsions silver nanoparticles antibacterial skin bacterial infection treatments |
| title | New Ionic Liquid Microemulsion-Mediated Synthesis of Silver Nanoparticles for Skin Bacterial Infection Treatments |
| title_full | New Ionic Liquid Microemulsion-Mediated Synthesis of Silver Nanoparticles for Skin Bacterial Infection Treatments |
| title_fullStr | New Ionic Liquid Microemulsion-Mediated Synthesis of Silver Nanoparticles for Skin Bacterial Infection Treatments |
| title_full_unstemmed | New Ionic Liquid Microemulsion-Mediated Synthesis of Silver Nanoparticles for Skin Bacterial Infection Treatments |
| title_short | New Ionic Liquid Microemulsion-Mediated Synthesis of Silver Nanoparticles for Skin Bacterial Infection Treatments |
| title_sort | new ionic liquid microemulsion mediated synthesis of silver nanoparticles for skin bacterial infection treatments |
| topic | benzyl alkyl imidazolium ionic liquids microemulsions silver nanoparticles antibacterial skin bacterial infection treatments |
| url | https://www.mdpi.com/2079-6382/12/2/247 |
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