Multiple chemical sensitivity scoping review protocol: overview of research and MCS construct
Introduction Multiple chemical sensitivity (MCS) has been characterised by reported adverse responses to environmental exposures of common chemical agents (eg, perfumes, paint, cleaning products and other inhaled or ingested agents) in low doses considered non-toxic for the general population. There...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2023-09-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/13/9/e072098.full |
| _version_ | 1797669499452784640 |
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| author | Jesús Rodríguez Karen A Robinson Aneesa Motala Susanne Hempel Jill Johnston Maria Bolshakova Sachi Yagyu Margie Danz Alanna Mears Cindy Pham Danica Tolentino Omid Akbari |
| author_facet | Jesús Rodríguez Karen A Robinson Aneesa Motala Susanne Hempel Jill Johnston Maria Bolshakova Sachi Yagyu Margie Danz Alanna Mears Cindy Pham Danica Tolentino Omid Akbari |
| author_sort | Jesús Rodríguez |
| collection | DOAJ |
| description | Introduction Multiple chemical sensitivity (MCS) has been characterised by reported adverse responses to environmental exposures of common chemical agents (eg, perfumes, paint, cleaning products and other inhaled or ingested agents) in low doses considered non-toxic for the general population. There is currently no consensus on whether MCS can be established as a distinct disorder.Methods and analysis The scoping review of the literature will be guided by five questions: How is MCS defined and which diagnostic criteria have been proposed? What methods are used to report prevalence and incidence estimates of MCS? What are the characteristics of the body of scientific evidence that addresses whether MCS is a distinct disorder or syndrome? What underlying mechanisms for MCS have been proposed in the scientific literature? Which treatment and management approaches for MCS have been evaluated in empirical research studies? We will conduct a comprehensive search in 14 research databases. Citation screening will be supported by machine learning algorithms. Two independent reviewers will assess eligibility of full-text publications against prespecified criteria. Data abstraction will support concise evidence tables. A formal consultation exercise will elicit input regarding the review results and presentation. The existing research evidence will be documented in a user-friendly visualisation in the format of an evidence map.Ethics and dissemination Determined to be exempt from review (UP-22-00516). Results will be disseminated through a journal manuscript and data will be publicly accessible through an online data repository.Registration details The protocol is registered in Open Science Framework (osf.io/4a3wu). |
| first_indexed | 2024-03-11T20:45:17Z |
| format | Article |
| id | doaj.art-53e60c0cfa0a4ddd9fe58187efea5979 |
| institution | Directory Open Access Journal |
| issn | 2044-6055 |
| language | English |
| last_indexed | 2024-03-11T20:45:17Z |
| publishDate | 2023-09-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj.art-53e60c0cfa0a4ddd9fe58187efea59792023-10-01T15:05:08ZengBMJ Publishing GroupBMJ Open2044-60552023-09-0113910.1136/bmjopen-2023-072098Multiple chemical sensitivity scoping review protocol: overview of research and MCS constructJesús Rodríguez0Karen A Robinson1Aneesa Motala2Susanne Hempel3Jill Johnston4Maria Bolshakova5Sachi Yagyu6Margie Danz7Alanna Mears8Cindy Pham9Danica Tolentino10Omid Akbari11Southern California Evidence Review Center, University of Southern California, Los Angeles, California, USADivision of Health Science Informatics, John Hopkins Medicine, Baltimore, Maryland, USASouthern California Evidence Review Center, University of Southern California, Los Angeles, California, USASouthern California Evidence Review Center, University of Southern California, Los Angeles, California, USAKeck School of Medicine, University of Southern California, Los Angeles, California, USASouthern California Evidence Review Center, University of Southern California, Los Angeles, California, USASouthern California Evidence Review Center, University of Southern California, Los Angeles, California, USASouthern California Evidence Review Center, University of Southern California, Los Angeles, California, USASouthern California Evidence Review Center, University of Southern California, Los Angeles, California, USASouthern California Evidence Review Center, University of Southern California, Los Angeles, California, USAKeck School of Medicine, University of Southern California, Los Angeles, California, USAMolecular Microbiology and Immunology, University of Southern California, Los Angeles, California, USAIntroduction Multiple chemical sensitivity (MCS) has been characterised by reported adverse responses to environmental exposures of common chemical agents (eg, perfumes, paint, cleaning products and other inhaled or ingested agents) in low doses considered non-toxic for the general population. There is currently no consensus on whether MCS can be established as a distinct disorder.Methods and analysis The scoping review of the literature will be guided by five questions: How is MCS defined and which diagnostic criteria have been proposed? What methods are used to report prevalence and incidence estimates of MCS? What are the characteristics of the body of scientific evidence that addresses whether MCS is a distinct disorder or syndrome? What underlying mechanisms for MCS have been proposed in the scientific literature? Which treatment and management approaches for MCS have been evaluated in empirical research studies? We will conduct a comprehensive search in 14 research databases. Citation screening will be supported by machine learning algorithms. Two independent reviewers will assess eligibility of full-text publications against prespecified criteria. Data abstraction will support concise evidence tables. A formal consultation exercise will elicit input regarding the review results and presentation. The existing research evidence will be documented in a user-friendly visualisation in the format of an evidence map.Ethics and dissemination Determined to be exempt from review (UP-22-00516). Results will be disseminated through a journal manuscript and data will be publicly accessible through an online data repository.Registration details The protocol is registered in Open Science Framework (osf.io/4a3wu).https://bmjopen.bmj.com/content/13/9/e072098.full |
| spellingShingle | Jesús Rodríguez Karen A Robinson Aneesa Motala Susanne Hempel Jill Johnston Maria Bolshakova Sachi Yagyu Margie Danz Alanna Mears Cindy Pham Danica Tolentino Omid Akbari Multiple chemical sensitivity scoping review protocol: overview of research and MCS construct BMJ Open |
| title | Multiple chemical sensitivity scoping review protocol: overview of research and MCS construct |
| title_full | Multiple chemical sensitivity scoping review protocol: overview of research and MCS construct |
| title_fullStr | Multiple chemical sensitivity scoping review protocol: overview of research and MCS construct |
| title_full_unstemmed | Multiple chemical sensitivity scoping review protocol: overview of research and MCS construct |
| title_short | Multiple chemical sensitivity scoping review protocol: overview of research and MCS construct |
| title_sort | multiple chemical sensitivity scoping review protocol overview of research and mcs construct |
| url | https://bmjopen.bmj.com/content/13/9/e072098.full |
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