Depressive symptoms are correlated with periaqueductal gray matter functional connectivity in migraine
Introduction Depression is the most common comorbidity of migraine. The brain of migraineurs with depression shows differences compared to migraine only or depression only patients. The comorbidity may affect specific regions such as the periaqueductal gray matter (PAG) which is important in negati...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Cambridge University Press
2022-06-01
|
| Series: | European Psychiatry |
| Subjects: | |
| Online Access: | https://www.cambridge.org/core/product/identifier/S0924933822016364/type/journal_article |
| _version_ | 1827753708370264064 |
|---|---|
| author | K. Gecse D. Dobos N. Károlyi D. Baksa C.S. Aranyi M. Emri G. Kökönyei G. Bagdy G. Juhasz |
| author_facet | K. Gecse D. Dobos N. Károlyi D. Baksa C.S. Aranyi M. Emri G. Kökönyei G. Bagdy G. Juhasz |
| author_sort | K. Gecse |
| collection | DOAJ |
| description |
Introduction
Depression is the most common comorbidity of migraine. The brain of migraineurs with depression shows differences compared to migraine only or depression only patients. The comorbidity may affect specific regions such as the periaqueductal gray matter (PAG) which is important in negative emotion regulation and pain modulatory system.
Objectives
We hypothesized that the alterations in PAG functional connectivity (FC) may play a role in migraineurs vulnerability for depression.
Methods
A resting-state fMRI was conducted with 34 episodic migraine without aura patients and 41 control subjects. All participants were medication free and they did not have any psychiatric or chronic disorders. Depressive symptoms were measured with Zung Self-Rating Depression Scale. To investigate the relationship between depressive symptoms and PAG functional connectivity, Zung scores were used as covariates in each groups’ PAG-FC analysis using the Statistical Parametric Mapping (SPM12) toolbox in MATLAB environment.
Results
There were no significant difference between migraine and control group in Zung scores (p=0.394). Negative correlation was found between Zung scores and PAG-FC with thalamus, fusiform gyrus, middle occipital gyrus and calcarine (pFWE<0.05) in migraine group. However, there was no significant correlation between Zung scores and PAG-FC in healthy control group.
Conclusions
Our results suggest that PAG-FC with emotion and pain processing areas is affected by depressive symptoms in migraine patients, but not in healthy controls. Migraine patients without comorbid depression might have vulnerable neuronal pathways for depressive symptoms. A follow-up of these patients could be interesting to determine whether these connectivity alterations predict the possible comorbid depression.
Disclosure
Hungarian Brain Research Program (2017-1.2.1-NKP-2017-00002, KTIA_13_NAPA-II/14, KTIA_NAP_13-1-2013- 0001, KTIA_NAP_13-2- 2015-0001); 2020-4.1.1.-TKP2020; ERA PerMed (2019-2.1.7-ERA-NET-2020-00005); ÚNKP-21-4-I-SE-15 (DB).
|
| first_indexed | 2024-03-11T07:38:59Z |
| format | Article |
| id | doaj.art-53e6b70a65c14c149e0bd2cd765f945e |
| institution | Directory Open Access Journal |
| issn | 0924-9338 1778-3585 |
| language | English |
| last_indexed | 2024-03-11T07:38:59Z |
| publishDate | 2022-06-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | European Psychiatry |
| spelling | doaj.art-53e6b70a65c14c149e0bd2cd765f945e2023-11-17T05:08:50ZengCambridge University PressEuropean Psychiatry0924-93381778-35852022-06-0165S638S63810.1192/j.eurpsy.2022.1636Depressive symptoms are correlated with periaqueductal gray matter functional connectivity in migraineK. Gecse0D. Dobos1N. Károlyi2D. Baksa3C.S. Aranyi4M. Emri5G. Kökönyei6G. Bagdy7G. Juhasz8Semmelweis University, Department Of Pharmacodynamics, Faculty Of Pharmacy, Budapest, Hungary Semmelweis University, Se-nap2 Genetic Brain Imaging Migraine Research Group, Budapest, HungarySemmelweis University, Department Of Pharmacodynamics, Faculty Of Pharmacy, Budapest, Hungary Semmelweis University, Se-nap2 Genetic Brain Imaging Migraine Research Group, Budapest, HungarySemmelweis University, Department Of Pharmacodynamics, Faculty Of Pharmacy, Budapest, Hungary Semmelweis University, Se-nap2 Genetic Brain Imaging Migraine Research Group, Budapest, HungarySemmelweis University, Department Of Pharmacodynamics, Faculty Of Pharmacy, Budapest, Hungary Semmelweis University, Se-nap2 Genetic Brain Imaging Migraine Research Group, Budapest, HungaryUniversity of Debrecen, Division Of Nuclear Medicine And Translational Imaging, Department Of Medical Imaging, Faculty Of Medicine, Debrecen, HungaryUniversity of Debrecen, Division Of Nuclear Medicine And Translational Imaging, Department Of Medical Imaging, Faculty Of Medicine, Debrecen, HungaryELTE Eötvös Loránd University, Institute Of Psychology, Budapest, HungarySemmelweis University, Department Of Pharmacodynamics, Faculty Of Pharmacy, Budapest, Hungary NAP-2-SE New Antidepressant Target Research Group, Hungarian Brain Research Program, Semmelweis University, Budapest, HungarySemmelweis University, Department Of Pharmacodynamics, Faculty Of Pharmacy, Budapest, Hungary Semmelweis University, Se-nap2 Genetic Brain Imaging Migraine Research Group, Budapest, Hungary Introduction Depression is the most common comorbidity of migraine. The brain of migraineurs with depression shows differences compared to migraine only or depression only patients. The comorbidity may affect specific regions such as the periaqueductal gray matter (PAG) which is important in negative emotion regulation and pain modulatory system. Objectives We hypothesized that the alterations in PAG functional connectivity (FC) may play a role in migraineurs vulnerability for depression. Methods A resting-state fMRI was conducted with 34 episodic migraine without aura patients and 41 control subjects. All participants were medication free and they did not have any psychiatric or chronic disorders. Depressive symptoms were measured with Zung Self-Rating Depression Scale. To investigate the relationship between depressive symptoms and PAG functional connectivity, Zung scores were used as covariates in each groups’ PAG-FC analysis using the Statistical Parametric Mapping (SPM12) toolbox in MATLAB environment. Results There were no significant difference between migraine and control group in Zung scores (p=0.394). Negative correlation was found between Zung scores and PAG-FC with thalamus, fusiform gyrus, middle occipital gyrus and calcarine (pFWE<0.05) in migraine group. However, there was no significant correlation between Zung scores and PAG-FC in healthy control group. Conclusions Our results suggest that PAG-FC with emotion and pain processing areas is affected by depressive symptoms in migraine patients, but not in healthy controls. Migraine patients without comorbid depression might have vulnerable neuronal pathways for depressive symptoms. A follow-up of these patients could be interesting to determine whether these connectivity alterations predict the possible comorbid depression. Disclosure Hungarian Brain Research Program (2017-1.2.1-NKP-2017-00002, KTIA_13_NAPA-II/14, KTIA_NAP_13-1-2013- 0001, KTIA_NAP_13-2- 2015-0001); 2020-4.1.1.-TKP2020; ERA PerMed (2019-2.1.7-ERA-NET-2020-00005); ÚNKP-21-4-I-SE-15 (DB). https://www.cambridge.org/core/product/identifier/S0924933822016364/type/journal_articlefMRImigrainedepressive symptomsPAG |
| spellingShingle | K. Gecse D. Dobos N. Károlyi D. Baksa C.S. Aranyi M. Emri G. Kökönyei G. Bagdy G. Juhasz Depressive symptoms are correlated with periaqueductal gray matter functional connectivity in migraine European Psychiatry fMRI migraine depressive symptoms PAG |
| title | Depressive symptoms are correlated with periaqueductal gray matter functional connectivity in migraine |
| title_full | Depressive symptoms are correlated with periaqueductal gray matter functional connectivity in migraine |
| title_fullStr | Depressive symptoms are correlated with periaqueductal gray matter functional connectivity in migraine |
| title_full_unstemmed | Depressive symptoms are correlated with periaqueductal gray matter functional connectivity in migraine |
| title_short | Depressive symptoms are correlated with periaqueductal gray matter functional connectivity in migraine |
| title_sort | depressive symptoms are correlated with periaqueductal gray matter functional connectivity in migraine |
| topic | fMRI migraine depressive symptoms PAG |
| url | https://www.cambridge.org/core/product/identifier/S0924933822016364/type/journal_article |
| work_keys_str_mv | AT kgecse depressivesymptomsarecorrelatedwithperiaqueductalgraymatterfunctionalconnectivityinmigraine AT ddobos depressivesymptomsarecorrelatedwithperiaqueductalgraymatterfunctionalconnectivityinmigraine AT nkarolyi depressivesymptomsarecorrelatedwithperiaqueductalgraymatterfunctionalconnectivityinmigraine AT dbaksa depressivesymptomsarecorrelatedwithperiaqueductalgraymatterfunctionalconnectivityinmigraine AT csaranyi depressivesymptomsarecorrelatedwithperiaqueductalgraymatterfunctionalconnectivityinmigraine AT memri depressivesymptomsarecorrelatedwithperiaqueductalgraymatterfunctionalconnectivityinmigraine AT gkokonyei depressivesymptomsarecorrelatedwithperiaqueductalgraymatterfunctionalconnectivityinmigraine AT gbagdy depressivesymptomsarecorrelatedwithperiaqueductalgraymatterfunctionalconnectivityinmigraine AT gjuhasz depressivesymptomsarecorrelatedwithperiaqueductalgraymatterfunctionalconnectivityinmigraine |