Allorecognition of HLA-C mismatches by CD8+ T cells in hematopoietic stem cell transplantation is a complex interplay between mismatched peptide binding region residues, HLA-C expression and HLA-DPB1 disparities

Allorecognition of HLA-C mismatches by CD8+ T cells in hematopoietic stem cell transplantation is a complex interplay between mismatched peptide binding region residues, HLA-C expression and HLA-DPB1 disparities

HLA-C locus mismatches are the most frequent class I disparities in unrelated hematopoietic stem cell transplantation (HSCT) and have a detrimental impact on clinical outcome. Recently, a few retrospective clinical studies have reported some variability in the immunogenicity of HLA-C incompatibiliti...

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Bibliographic Details
Main Authors: Florence Bettens, Stépahne Buhler, Jean-Marie Tiercy
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-12-01
Series:Frontiers in Immunology
Subjects:
Stem Cell Transplantation
alloreactivity
in vitro culture
cytotoxic T lymphocyte (CTL)
HLA-C
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00584/full

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