Recent Advances in Polymeric Nanoparticle-Encapsulated Drugs against Intracellular Infections
Polymeric nanocarriers (PNs) have demonstrated to be a promising alternative to treat intracellular infections. They have outstanding performance in delivering antimicrobials intracellularly to reach an adequate dose level and improve their therapeutic efficacy. PNs offer opportunities for preventin...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-08-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/25/16/3760 |
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| author | Arturo Sánchez Susana P. Mejía Jahir Orozco |
| author_facet | Arturo Sánchez Susana P. Mejía Jahir Orozco |
| author_sort | Arturo Sánchez |
| collection | DOAJ |
| description | Polymeric nanocarriers (PNs) have demonstrated to be a promising alternative to treat intracellular infections. They have outstanding performance in delivering antimicrobials intracellularly to reach an adequate dose level and improve their therapeutic efficacy. PNs offer opportunities for preventing unwanted drug interactions and degradation before reaching the target cell of tissue and thus decreasing the development of resistance in microorganisms. The use of PNs has the potential to reduce the dose and adverse side effects, providing better efficiency and effectiveness of therapeutic regimens, especially in drugs having high toxicity, low solubility in the physiological environment and low bioavailability. This review provides an overview of nanoparticles made of different polymeric precursors and the main methodologies to nanofabricate platforms of tuned physicochemical and morphological properties and surface chemistry for controlled release of antimicrobials in the target. It highlights the versatility of these nanosystems and their challenges and opportunities to deliver antimicrobial drugs to treat intracellular infections and mentions nanotoxicology aspects and future outlooks. |
| first_indexed | 2024-03-10T17:16:10Z |
| format | Article |
| id | doaj.art-53eaabaa35b3428fb9a39a4697276b04 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T17:16:10Z |
| publishDate | 2020-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-53eaabaa35b3428fb9a39a4697276b042023-11-20T10:30:25ZengMDPI AGMolecules1420-30492020-08-012516376010.3390/molecules25163760Recent Advances in Polymeric Nanoparticle-Encapsulated Drugs against Intracellular InfectionsArturo Sánchez0Susana P. Mejía1Jahir Orozco2Max Planck Tandem Group in Nanobioengineering, University of Antioquia, Complejo Ruta N, Calle 67 Nº 52-20, Medellín 050010, ColombiaMax Planck Tandem Group in Nanobioengineering, University of Antioquia, Complejo Ruta N, Calle 67 Nº 52-20, Medellín 050010, ColombiaMax Planck Tandem Group in Nanobioengineering, University of Antioquia, Complejo Ruta N, Calle 67 Nº 52-20, Medellín 050010, ColombiaPolymeric nanocarriers (PNs) have demonstrated to be a promising alternative to treat intracellular infections. They have outstanding performance in delivering antimicrobials intracellularly to reach an adequate dose level and improve their therapeutic efficacy. PNs offer opportunities for preventing unwanted drug interactions and degradation before reaching the target cell of tissue and thus decreasing the development of resistance in microorganisms. The use of PNs has the potential to reduce the dose and adverse side effects, providing better efficiency and effectiveness of therapeutic regimens, especially in drugs having high toxicity, low solubility in the physiological environment and low bioavailability. This review provides an overview of nanoparticles made of different polymeric precursors and the main methodologies to nanofabricate platforms of tuned physicochemical and morphological properties and surface chemistry for controlled release of antimicrobials in the target. It highlights the versatility of these nanosystems and their challenges and opportunities to deliver antimicrobial drugs to treat intracellular infections and mentions nanotoxicology aspects and future outlooks.https://www.mdpi.com/1420-3049/25/16/3760polymeric nanocarriersintracellular infectionsdrugspolymeric propertiesadministration routepharmacokinetics |
| spellingShingle | Arturo Sánchez Susana P. Mejía Jahir Orozco Recent Advances in Polymeric Nanoparticle-Encapsulated Drugs against Intracellular Infections Molecules polymeric nanocarriers intracellular infections drugs polymeric properties administration route pharmacokinetics |
| title | Recent Advances in Polymeric Nanoparticle-Encapsulated Drugs against Intracellular Infections |
| title_full | Recent Advances in Polymeric Nanoparticle-Encapsulated Drugs against Intracellular Infections |
| title_fullStr | Recent Advances in Polymeric Nanoparticle-Encapsulated Drugs against Intracellular Infections |
| title_full_unstemmed | Recent Advances in Polymeric Nanoparticle-Encapsulated Drugs against Intracellular Infections |
| title_short | Recent Advances in Polymeric Nanoparticle-Encapsulated Drugs against Intracellular Infections |
| title_sort | recent advances in polymeric nanoparticle encapsulated drugs against intracellular infections |
| topic | polymeric nanocarriers intracellular infections drugs polymeric properties administration route pharmacokinetics |
| url | https://www.mdpi.com/1420-3049/25/16/3760 |
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