Longitudinal decrease in blood oxygenation level dependent response in cerebral amyloid angiopathy
Lower blood oxygenation level dependent (BOLD) signal changes in response to a visual stimulus in functional magnetic resonance imaging (fMRI) have been observed in cross-sectional studies of cerebral amyloid angiopathy (CAA), and are presumed to reflect impaired vascular reactivity. We used fMRI to...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2016-01-01
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| Series: | NeuroImage: Clinical |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213158216300419 |
| _version_ | 1811256151909597184 |
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| author | Aaron R. Switzer Cheryl McCreary Saima Batool Randall B. Stafford Richard Frayne Bradley G. Goodyear Eric E. Smith |
| author_facet | Aaron R. Switzer Cheryl McCreary Saima Batool Randall B. Stafford Richard Frayne Bradley G. Goodyear Eric E. Smith |
| author_sort | Aaron R. Switzer |
| collection | DOAJ |
| description | Lower blood oxygenation level dependent (BOLD) signal changes in response to a visual stimulus in functional magnetic resonance imaging (fMRI) have been observed in cross-sectional studies of cerebral amyloid angiopathy (CAA), and are presumed to reflect impaired vascular reactivity. We used fMRI to detect a longitudinal change in BOLD responses to a visual stimulus in CAA, and to determine any correlations between these changes and other established biomarkers of CAA progression. Data were acquired from 22 patients diagnosed with probable CAA (using the Boston Criteria) and 16 healthy controls at baseline and one year. BOLD data were generated from the 200 most active voxels of the primary visual cortex during the fMRI visual stimulus (passively viewing an alternating checkerboard pattern). In general, BOLD amplitudes were lower at one year compared to baseline in patients with CAA (p = 0.01) but were unchanged in controls (p = 0.18). The longitudinal difference in BOLD amplitudes was significantly lower in CAA compared to controls (p < 0.001). White matter hyperintensity (WMH) volumes and number of cerebral microbleeds, both presumed to reflect CAA-mediated vascular injury, increased over time in CAA (p = 0.007 and p = 0.001, respectively). Longitudinal increases in WMH (rs = 0.04, p = 0.86) or cerebral microbleeds (rs = −0.18, p = 0.45) were not associated with the longitudinal decrease in BOLD amplitudes. |
| first_indexed | 2024-04-12T17:35:48Z |
| format | Article |
| id | doaj.art-53eac7b536804183a05152605cf39ad9 |
| institution | Directory Open Access Journal |
| issn | 2213-1582 |
| language | English |
| last_indexed | 2024-04-12T17:35:48Z |
| publishDate | 2016-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage: Clinical |
| spelling | doaj.art-53eac7b536804183a05152605cf39ad92022-12-22T03:22:59ZengElsevierNeuroImage: Clinical2213-15822016-01-0111C46146710.1016/j.nicl.2016.02.020Longitudinal decrease in blood oxygenation level dependent response in cerebral amyloid angiopathyAaron R. Switzer0Cheryl McCreary1Saima Batool2Randall B. Stafford3Richard Frayne4Bradley G. Goodyear5Eric E. Smith6Neuroscience Graduate Program, University of Calgary, CanadaDepartment of Radiology, University of Calgary, CanadaDepartment of Clinical Neurosciences, University of Calgary, CanadaDepartment of Clinical Neurosciences, University of Calgary, CanadaNeuroscience Graduate Program, University of Calgary, CanadaNeuroscience Graduate Program, University of Calgary, CanadaNeuroscience Graduate Program, University of Calgary, CanadaLower blood oxygenation level dependent (BOLD) signal changes in response to a visual stimulus in functional magnetic resonance imaging (fMRI) have been observed in cross-sectional studies of cerebral amyloid angiopathy (CAA), and are presumed to reflect impaired vascular reactivity. We used fMRI to detect a longitudinal change in BOLD responses to a visual stimulus in CAA, and to determine any correlations between these changes and other established biomarkers of CAA progression. Data were acquired from 22 patients diagnosed with probable CAA (using the Boston Criteria) and 16 healthy controls at baseline and one year. BOLD data were generated from the 200 most active voxels of the primary visual cortex during the fMRI visual stimulus (passively viewing an alternating checkerboard pattern). In general, BOLD amplitudes were lower at one year compared to baseline in patients with CAA (p = 0.01) but were unchanged in controls (p = 0.18). The longitudinal difference in BOLD amplitudes was significantly lower in CAA compared to controls (p < 0.001). White matter hyperintensity (WMH) volumes and number of cerebral microbleeds, both presumed to reflect CAA-mediated vascular injury, increased over time in CAA (p = 0.007 and p = 0.001, respectively). Longitudinal increases in WMH (rs = 0.04, p = 0.86) or cerebral microbleeds (rs = −0.18, p = 0.45) were not associated with the longitudinal decrease in BOLD amplitudes.http://www.sciencedirect.com/science/article/pii/S2213158216300419Cerebral amyloid angiopathyFunctional magnetic resonance imaging |
| spellingShingle | Aaron R. Switzer Cheryl McCreary Saima Batool Randall B. Stafford Richard Frayne Bradley G. Goodyear Eric E. Smith Longitudinal decrease in blood oxygenation level dependent response in cerebral amyloid angiopathy NeuroImage: Clinical Cerebral amyloid angiopathy Functional magnetic resonance imaging |
| title | Longitudinal decrease in blood oxygenation level dependent response in cerebral amyloid angiopathy |
| title_full | Longitudinal decrease in blood oxygenation level dependent response in cerebral amyloid angiopathy |
| title_fullStr | Longitudinal decrease in blood oxygenation level dependent response in cerebral amyloid angiopathy |
| title_full_unstemmed | Longitudinal decrease in blood oxygenation level dependent response in cerebral amyloid angiopathy |
| title_short | Longitudinal decrease in blood oxygenation level dependent response in cerebral amyloid angiopathy |
| title_sort | longitudinal decrease in blood oxygenation level dependent response in cerebral amyloid angiopathy |
| topic | Cerebral amyloid angiopathy Functional magnetic resonance imaging |
| url | http://www.sciencedirect.com/science/article/pii/S2213158216300419 |
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