GRAMD4 inhibits tumour metastasis by recruiting the E3 ligase ITCH to target TAK1 for degradation in hepatocellular carcinoma

GRAMD4 inhibits tumour metastasis by recruiting the E3 ligase ITCH to target TAK1 for degradation in hepatocellular carcinoma

Abstract Background Aberrant TAK1 (transforming growth factor β‐activated kinase 1) activity is known to be involved in a variety of malignancies, but the regulatory mechanisms of TAK1 remain poorly understood. GRAMD4 (glucosyltransferase Rab‐like GTPase activator and myotubularin domain containing...

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Bibliographic Details
Main Authors: Qian yun Ge, Jin Chen, Gan xun Li, Xiao long Tan, Jia Song, Deng Ning, Jie Mo, Peng cheng Du, Qiu meng Liu, Hui fang Liang, Ze yang Ding, Xue wu Zhang, Bi xiang Zhang
Format: Article
Language:English
Published: Wiley 2021-11-01
Series:Clinical and Translational Medicine
Subjects:
GRAMD4
HCC
Metastasis
TAK1
Ubiquitination
Online Access:https://doi.org/10.1002/ctm2.635

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