Effects of remifemin treatment on bone integrity and remodeling in rats with ovariectomy-induced osteoporosis.
This study aims to evaluate the effects of Remifemin (isopropanolic extract of Cimicifuga Racemosa) on postmenopausal osteoporosis. 120 female Sprague-Dawley rats were randomly assigned to four groups: sham surgery with vehicle, ovariectomy with vehicle, ovariectomy with estradiol valerate, or ovari...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3857312?pdf=render |
| _version_ | 1819117481728409600 |
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| author | Guangxia Cui Huijie Leng Ke Wang Jianwei Wang Sainan Zhu Jing Jia Xing Chen Weiguang Zhang Lihua Qin Wenpei Bai |
| author_facet | Guangxia Cui Huijie Leng Ke Wang Jianwei Wang Sainan Zhu Jing Jia Xing Chen Weiguang Zhang Lihua Qin Wenpei Bai |
| author_sort | Guangxia Cui |
| collection | DOAJ |
| description | This study aims to evaluate the effects of Remifemin (isopropanolic extract of Cimicifuga Racemosa) on postmenopausal osteoporosis. 120 female Sprague-Dawley rats were randomly assigned to four groups: sham surgery with vehicle, ovariectomy with vehicle, ovariectomy with estradiol valerate, or ovariectomy with Remifemin. Daily oral administrations of the vehicle, estradiol valerate, or Remifemin began 2 weeks after surgery and lasted to 4, 8, or 12 weeks. Ten rats in each group were sacrificed at each timestep with assessment of bone mineral density, trabecular bone structure, and biomechanical parameters of the femur and lumbar vertebra. Bone turnover markers were evaluated 12 weeks after surgery. Both drugs prevented bone density loss in the distal end of the femur and preserved the trabecular bone structure in both the lumbar vertebra and distal end of the femur following ovariectomy. Both drugs protected bone stiffness at the tested regions and reduced bone reabsorption in ovariectomized rats. The preventive effects of Remifemin against bone-loss can rival those of estradiol valerate if treatment duration is adequately extended. In conclusion, Remifemin may demonstrate equivalent effects to estradiol valerate in terms of preventing postmenopausal osteoporosis. |
| first_indexed | 2024-12-22T05:33:40Z |
| format | Article |
| id | doaj.art-53ee811c2ba7461e94628ba09ba2df43 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-22T05:33:40Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-53ee811c2ba7461e94628ba09ba2df432022-12-21T18:37:24ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-01812e8281510.1371/journal.pone.0082815Effects of remifemin treatment on bone integrity and remodeling in rats with ovariectomy-induced osteoporosis.Guangxia CuiHuijie LengKe WangJianwei WangSainan ZhuJing JiaXing ChenWeiguang ZhangLihua QinWenpei BaiThis study aims to evaluate the effects of Remifemin (isopropanolic extract of Cimicifuga Racemosa) on postmenopausal osteoporosis. 120 female Sprague-Dawley rats were randomly assigned to four groups: sham surgery with vehicle, ovariectomy with vehicle, ovariectomy with estradiol valerate, or ovariectomy with Remifemin. Daily oral administrations of the vehicle, estradiol valerate, or Remifemin began 2 weeks after surgery and lasted to 4, 8, or 12 weeks. Ten rats in each group were sacrificed at each timestep with assessment of bone mineral density, trabecular bone structure, and biomechanical parameters of the femur and lumbar vertebra. Bone turnover markers were evaluated 12 weeks after surgery. Both drugs prevented bone density loss in the distal end of the femur and preserved the trabecular bone structure in both the lumbar vertebra and distal end of the femur following ovariectomy. Both drugs protected bone stiffness at the tested regions and reduced bone reabsorption in ovariectomized rats. The preventive effects of Remifemin against bone-loss can rival those of estradiol valerate if treatment duration is adequately extended. In conclusion, Remifemin may demonstrate equivalent effects to estradiol valerate in terms of preventing postmenopausal osteoporosis.http://europepmc.org/articles/PMC3857312?pdf=render |
| spellingShingle | Guangxia Cui Huijie Leng Ke Wang Jianwei Wang Sainan Zhu Jing Jia Xing Chen Weiguang Zhang Lihua Qin Wenpei Bai Effects of remifemin treatment on bone integrity and remodeling in rats with ovariectomy-induced osteoporosis. PLoS ONE |
| title | Effects of remifemin treatment on bone integrity and remodeling in rats with ovariectomy-induced osteoporosis. |
| title_full | Effects of remifemin treatment on bone integrity and remodeling in rats with ovariectomy-induced osteoporosis. |
| title_fullStr | Effects of remifemin treatment on bone integrity and remodeling in rats with ovariectomy-induced osteoporosis. |
| title_full_unstemmed | Effects of remifemin treatment on bone integrity and remodeling in rats with ovariectomy-induced osteoporosis. |
| title_short | Effects of remifemin treatment on bone integrity and remodeling in rats with ovariectomy-induced osteoporosis. |
| title_sort | effects of remifemin treatment on bone integrity and remodeling in rats with ovariectomy induced osteoporosis |
| url | http://europepmc.org/articles/PMC3857312?pdf=render |
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