Assessment of Arterial Transit Time and Cerebrovascular Reactivity in Moyamoya Disease by Simultaneous PET/MRI
We investigated the relationship between MRI-arterial spin labeling (ASL) parameters and PET-cerebral blood flow (CBF)/cerebrovascular reactivity (CVR) simultaneously obtained by PET/MRI in Moyamoya disease. Twelve patients underwent <sup>15</sup>O-water PET/MRI with the acetazolamide (A...
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MDPI AG
2023-02-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/13/4/756 |
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| author | Kenji Takata Hirohiko Kimura Shota Ishida Makoto Isozaki Yoshifumi Higashino Ken-Ichiro Kikuta Hidehiko Okazawa Tetsuya Tsujikawa |
| author_facet | Kenji Takata Hirohiko Kimura Shota Ishida Makoto Isozaki Yoshifumi Higashino Ken-Ichiro Kikuta Hidehiko Okazawa Tetsuya Tsujikawa |
| author_sort | Kenji Takata |
| collection | DOAJ |
| description | We investigated the relationship between MRI-arterial spin labeling (ASL) parameters and PET-cerebral blood flow (CBF)/cerebrovascular reactivity (CVR) simultaneously obtained by PET/MRI in Moyamoya disease. Twelve patients underwent <sup>15</sup>O-water PET/MRI with the acetazolamide (ACZ) challenge test. PET-CBF and PET-CVR were measured using <sup>15</sup>O-water PET. Pseudo-continuous ASL obtained the robust arterial transit time (ATT) and ASL-CBF estimation. ASL parameters were compared with PET-CBF and PET-CVR. Before ACZ loading, absolute and relative ASL-CBF were significantly correlated with absolute and relative PET-CBF (r = 0.44, <i>p</i> < 0.0001, and r = 0.55, <i>p</i> < 0.0001, respectively). After ACZ loading, absolute and relative ASL-CBF were significantly correlated with absolute and relative PET-CBF (r = 0.56, <i>p</i> < 0.001, and r = 0.75, <i>p</i> < 0.0001, respectively), and ΔASL-CBF was significantly correlated with ΔPET-CBF (r = 0.65, <i>p</i> < 0.0001). Baseline ASL-ATT had strong negative correlations with ΔPET-CBF and PET-CVR (r = −0.72, <i>p</i> < 0.0001, and r = −0.66, <i>p</i> < 0.0001, respectively). Baseline ASL-ATT of MCA territories with CVR <30% (1546 ± 79 ms) was significantly higher than that with CVR > 30% (898 ± 197 ms). ASL-ATT ratio of MCA territories with CVR < 30% (94.0 ± 10.5%) was significantly higher than that with CVR > 30% (81.4 ± 11.3%). ATT correction using multiple postlabeling delays increased the accuracy of ASL-CBF quantitation. Baseline ASL-ATT is a hemodynamic parameter and may represent an efficient alternative to PET-CVR. |
| first_indexed | 2024-03-11T08:56:53Z |
| format | Article |
| id | doaj.art-53eeb68c68904f3aa356ee49eccc4745 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-11T08:56:53Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-53eeb68c68904f3aa356ee49eccc47452023-11-16T20:02:32ZengMDPI AGDiagnostics2075-44182023-02-0113475610.3390/diagnostics13040756Assessment of Arterial Transit Time and Cerebrovascular Reactivity in Moyamoya Disease by Simultaneous PET/MRIKenji Takata0Hirohiko Kimura1Shota Ishida2Makoto Isozaki3Yoshifumi Higashino4Ken-Ichiro Kikuta5Hidehiko Okazawa6Tetsuya Tsujikawa7Department of Radiology, Faculty of Medical Sciences, University of Fukui, Fukui 910-1193, JapanDepartment of Radiology, Faculty of Medical Sciences, University of Fukui, Fukui 910-1193, JapanDepartment of Radiological Technology, Faculty of Medical Sciences, Kyoto College of Medical Science, Kyoto 622-0041, JapanDepartment of Neurosurgery, Faculty of Medical Sciences, University of Fukui, Fukui 910-1193, JapanDepartment of Neurosurgery, Faculty of Medical Sciences, University of Fukui, Fukui 910-1193, JapanDepartment of Neurosurgery, Faculty of Medical Sciences, University of Fukui, Fukui 910-1193, JapanBiomedical Imaging Research Center, University of Fukui, Fukui 910-1193, JapanDepartment of Radiology, Faculty of Medical Sciences, University of Fukui, Fukui 910-1193, JapanWe investigated the relationship between MRI-arterial spin labeling (ASL) parameters and PET-cerebral blood flow (CBF)/cerebrovascular reactivity (CVR) simultaneously obtained by PET/MRI in Moyamoya disease. Twelve patients underwent <sup>15</sup>O-water PET/MRI with the acetazolamide (ACZ) challenge test. PET-CBF and PET-CVR were measured using <sup>15</sup>O-water PET. Pseudo-continuous ASL obtained the robust arterial transit time (ATT) and ASL-CBF estimation. ASL parameters were compared with PET-CBF and PET-CVR. Before ACZ loading, absolute and relative ASL-CBF were significantly correlated with absolute and relative PET-CBF (r = 0.44, <i>p</i> < 0.0001, and r = 0.55, <i>p</i> < 0.0001, respectively). After ACZ loading, absolute and relative ASL-CBF were significantly correlated with absolute and relative PET-CBF (r = 0.56, <i>p</i> < 0.001, and r = 0.75, <i>p</i> < 0.0001, respectively), and ΔASL-CBF was significantly correlated with ΔPET-CBF (r = 0.65, <i>p</i> < 0.0001). Baseline ASL-ATT had strong negative correlations with ΔPET-CBF and PET-CVR (r = −0.72, <i>p</i> < 0.0001, and r = −0.66, <i>p</i> < 0.0001, respectively). Baseline ASL-ATT of MCA territories with CVR <30% (1546 ± 79 ms) was significantly higher than that with CVR > 30% (898 ± 197 ms). ASL-ATT ratio of MCA territories with CVR < 30% (94.0 ± 10.5%) was significantly higher than that with CVR > 30% (81.4 ± 11.3%). ATT correction using multiple postlabeling delays increased the accuracy of ASL-CBF quantitation. Baseline ASL-ATT is a hemodynamic parameter and may represent an efficient alternative to PET-CVR.https://www.mdpi.com/2075-4418/13/4/756ASL-CBFASL-ATTPET-CBFPET-CVRMoyamoya disease |
| spellingShingle | Kenji Takata Hirohiko Kimura Shota Ishida Makoto Isozaki Yoshifumi Higashino Ken-Ichiro Kikuta Hidehiko Okazawa Tetsuya Tsujikawa Assessment of Arterial Transit Time and Cerebrovascular Reactivity in Moyamoya Disease by Simultaneous PET/MRI Diagnostics ASL-CBF ASL-ATT PET-CBF PET-CVR Moyamoya disease |
| title | Assessment of Arterial Transit Time and Cerebrovascular Reactivity in Moyamoya Disease by Simultaneous PET/MRI |
| title_full | Assessment of Arterial Transit Time and Cerebrovascular Reactivity in Moyamoya Disease by Simultaneous PET/MRI |
| title_fullStr | Assessment of Arterial Transit Time and Cerebrovascular Reactivity in Moyamoya Disease by Simultaneous PET/MRI |
| title_full_unstemmed | Assessment of Arterial Transit Time and Cerebrovascular Reactivity in Moyamoya Disease by Simultaneous PET/MRI |
| title_short | Assessment of Arterial Transit Time and Cerebrovascular Reactivity in Moyamoya Disease by Simultaneous PET/MRI |
| title_sort | assessment of arterial transit time and cerebrovascular reactivity in moyamoya disease by simultaneous pet mri |
| topic | ASL-CBF ASL-ATT PET-CBF PET-CVR Moyamoya disease |
| url | https://www.mdpi.com/2075-4418/13/4/756 |
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