Monitoring and significance of the recessive genetic defect AH1 of Ayrshire cattle
Modern dairy farming is characterised by high selection intensity and the use of a limited number of bulls-producers. This increases the likelihood of widespread genetic defects in livestock populations. Genome-wide studies have identified DNA loci associated with the disruption of foetal embryonic...
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Czech Academy of Agricultural Sciences
2020-09-01
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| Series: | Czech Journal of Animal Science |
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| Online Access: | https://cjas.agriculturejournals.cz/artkey/cjs-202009-0001_monitoring-and-significance-of-the-recessive-genetic-defect-ah1-of-ayrshire-cattle.php |
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| author | Marina Pozovnikova Olga Tulinova Anna Krutikova Olga Mitrofanova Nataliy Dementieva |
| author_facet | Marina Pozovnikova Olga Tulinova Anna Krutikova Olga Mitrofanova Nataliy Dementieva |
| author_sort | Marina Pozovnikova |
| collection | DOAJ |
| description | Modern dairy farming is characterised by high selection intensity and the use of a limited number of bulls-producers. This increases the likelihood of widespread genetic defects in livestock populations. Genome-wide studies have identified DNA loci associated with the disruption of foetal embryonic development and its death, which have been called "fertility haplotypes". The aim of this study is to analyse the occurrence of АН1 haplotype or rs475678587 in Ayrshire bulls (n = 186) used in the artificial insemination system of Russia and to evaluate the reproductive and productive qualities of their daughters. The proportion of genetic defect carrier bulls in the analysed sample cohort was 16.66%. Analysis of the proportion of carriers of unwanted haplotype depending on the place of birth of the bull for service showed that the highest frequency was observed in bulls of Canadian origin (26.66%). Based on data on 97 478 cow and heifer calvings, stillbirth and abortion rates were analysed and cow reproduction rates were based on an AH1 status for the bull-father and bull for service. We observed a significant increase (P < 0.05 and P < 0.001) in the incidence of stillbirths when crossing the daughters of AH1-C bulls with AH1-C bulls. There was no negative association of abortion rates and reproductive qualities with AH1 haplotype. The high incidence of AH1 haplotype among animals of Ayrshire breed requires regular screening for the carriers of this haplotype not only among bulls, but also in cows. |
| first_indexed | 2024-04-10T08:24:59Z |
| format | Article |
| id | doaj.art-53f01075cbbd4016a569c7b8a086e921 |
| institution | Directory Open Access Journal |
| issn | 1212-1819 1805-9309 |
| language | English |
| last_indexed | 2024-04-10T08:24:59Z |
| publishDate | 2020-09-01 |
| publisher | Czech Academy of Agricultural Sciences |
| record_format | Article |
| series | Czech Journal of Animal Science |
| spelling | doaj.art-53f01075cbbd4016a569c7b8a086e9212023-02-23T03:33:45ZengCzech Academy of Agricultural SciencesCzech Journal of Animal Science1212-18191805-93092020-09-0165932332910.17221/110/2020-CJAScjs-202009-0001Monitoring and significance of the recessive genetic defect AH1 of Ayrshire cattleMarina PozovnikovaOlga Tulinova0Anna Krutikova1Olga Mitrofanova2Nataliy Dementieva3Russian Research Institute for Farm Animal Genetics and Breeding - Branch of the L. K. Ernst Federal Science Center for Animal Husbandry (RRIFAGB), St. Petersburg, Russian FederationRussian Research Institute for Farm Animal Genetics and Breeding - Branch of the L. K. Ernst Federal Science Center for Animal Husbandry (RRIFAGB), St. Petersburg, Russian FederationRussian Research Institute for Farm Animal Genetics and Breeding - Branch of the L. K. Ernst Federal Science Center for Animal Husbandry (RRIFAGB), St. Petersburg, Russian FederationRussian Research Institute for Farm Animal Genetics and Breeding - Branch of the L. K. Ernst Federal Science Center for Animal Husbandry (RRIFAGB), St. Petersburg, Russian FederationModern dairy farming is characterised by high selection intensity and the use of a limited number of bulls-producers. This increases the likelihood of widespread genetic defects in livestock populations. Genome-wide studies have identified DNA loci associated with the disruption of foetal embryonic development and its death, which have been called "fertility haplotypes". The aim of this study is to analyse the occurrence of АН1 haplotype or rs475678587 in Ayrshire bulls (n = 186) used in the artificial insemination system of Russia and to evaluate the reproductive and productive qualities of their daughters. The proportion of genetic defect carrier bulls in the analysed sample cohort was 16.66%. Analysis of the proportion of carriers of unwanted haplotype depending on the place of birth of the bull for service showed that the highest frequency was observed in bulls of Canadian origin (26.66%). Based on data on 97 478 cow and heifer calvings, stillbirth and abortion rates were analysed and cow reproduction rates were based on an AH1 status for the bull-father and bull for service. We observed a significant increase (P < 0.05 and P < 0.001) in the incidence of stillbirths when crossing the daughters of AH1-C bulls with AH1-C bulls. There was no negative association of abortion rates and reproductive qualities with AH1 haplotype. The high incidence of AH1 haplotype among animals of Ayrshire breed requires regular screening for the carriers of this haplotype not only among bulls, but also in cows.https://cjas.agriculturejournals.cz/artkey/cjs-202009-0001_monitoring-and-significance-of-the-recessive-genetic-defect-ah1-of-ayrshire-cattle.phpabortionayrshire breedgenetic defectshaplotype fertilitystillbirth |
| spellingShingle | Marina Pozovnikova Olga Tulinova Anna Krutikova Olga Mitrofanova Nataliy Dementieva Monitoring and significance of the recessive genetic defect AH1 of Ayrshire cattle Czech Journal of Animal Science abortion ayrshire breed genetic defects haplotype fertility stillbirth |
| title | Monitoring and significance of the recessive genetic defect AH1 of Ayrshire cattle |
| title_full | Monitoring and significance of the recessive genetic defect AH1 of Ayrshire cattle |
| title_fullStr | Monitoring and significance of the recessive genetic defect AH1 of Ayrshire cattle |
| title_full_unstemmed | Monitoring and significance of the recessive genetic defect AH1 of Ayrshire cattle |
| title_short | Monitoring and significance of the recessive genetic defect AH1 of Ayrshire cattle |
| title_sort | monitoring and significance of the recessive genetic defect ah1 of ayrshire cattle |
| topic | abortion ayrshire breed genetic defects haplotype fertility stillbirth |
| url | https://cjas.agriculturejournals.cz/artkey/cjs-202009-0001_monitoring-and-significance-of-the-recessive-genetic-defect-ah1-of-ayrshire-cattle.php |
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