Metformin Alleviates Obesity and Systemic Oxidative Stress in Obese Young Swine
The present study assessed the relationship between obesity induced by lifestyle and systemic oxidative stress and possible modulations by oral metformin treatments in young individuals, by using a translational swine model of obesity and associated cardiometabolic disorders (Iberian pig). The resul...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-07-01
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| Series: | Pharmaceuticals |
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| Online Access: | https://www.mdpi.com/1424-8247/13/7/142 |
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| author | Susana Astiz Antonio Gonzalez-Bulnes Isabel Astiz Alicia Barbero Jose Luis Pesantez-Pacheco Consolacion Garcia-Contreras Marta Vazquez-Gomez Ana Heras-Molina |
| author_facet | Susana Astiz Antonio Gonzalez-Bulnes Isabel Astiz Alicia Barbero Jose Luis Pesantez-Pacheco Consolacion Garcia-Contreras Marta Vazquez-Gomez Ana Heras-Molina |
| author_sort | Susana Astiz |
| collection | DOAJ |
| description | The present study assessed the relationship between obesity induced by lifestyle and systemic oxidative stress and possible modulations by oral metformin treatments in young individuals, by using a translational swine model of obesity and associated cardiometabolic disorders (Iberian pig). The results indicate the existence of an age-related increase in both adiposity and systemic oxidative stress (using hydrogen peroxide as a marker), which is higher in individuals with obesogenic lifestyle and increased weight and obesity. Such effect was not found in individuals treated with metformin. The translation of these results suggests that childhood obesity increases production of reactive oxygen species (ROS), and therefore systemic oxidative stress. Treatment with metformin would improve such oxidative status. |
| first_indexed | 2024-03-10T18:39:25Z |
| format | Article |
| id | doaj.art-53f058b7d7854dc6bc95bd38d07ec67c |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-10T18:39:25Z |
| publishDate | 2020-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-53f058b7d7854dc6bc95bd38d07ec67c2023-11-20T05:56:06ZengMDPI AGPharmaceuticals1424-82472020-07-0113714210.3390/ph13070142Metformin Alleviates Obesity and Systemic Oxidative Stress in Obese Young SwineSusana Astiz0Antonio Gonzalez-Bulnes1Isabel Astiz2Alicia Barbero3Jose Luis Pesantez-Pacheco4Consolacion Garcia-Contreras5Marta Vazquez-Gomez6Ana Heras-Molina7INIA-Madrid, Avda. Puerta de Hierro s/n, 28040 Madrid, SpainINIA-Madrid, Avda. Puerta de Hierro s/n, 28040 Madrid, SpainUnidad de Pediatría, Atención Primaria, Centro de Salud Puerta Bonita, Calle de la Alegría 24, 28025 Madrid, SpainServicio de Diagnostico por Imagen, Universidad Alfonso X El Sabio, Avenida de la Universidad 1, 28691 Villanueva de la Cañada, SpainINIA-Madrid, Avda. Puerta de Hierro s/n, 28040 Madrid, SpainINIA-Madrid, Avda. Puerta de Hierro s/n, 28040 Madrid, SpainFacultad de Veterinaria, Universidad Complutense de Madrid, Ciudad Universitaria s/n, 28040 Madrid, SpainINIA-Madrid, Avda. Puerta de Hierro s/n, 28040 Madrid, SpainThe present study assessed the relationship between obesity induced by lifestyle and systemic oxidative stress and possible modulations by oral metformin treatments in young individuals, by using a translational swine model of obesity and associated cardiometabolic disorders (Iberian pig). The results indicate the existence of an age-related increase in both adiposity and systemic oxidative stress (using hydrogen peroxide as a marker), which is higher in individuals with obesogenic lifestyle and increased weight and obesity. Such effect was not found in individuals treated with metformin. The translation of these results suggests that childhood obesity increases production of reactive oxygen species (ROS), and therefore systemic oxidative stress. Treatment with metformin would improve such oxidative status.https://www.mdpi.com/1424-8247/13/7/142metforminobesityoxidative-stresspediatrics |
| spellingShingle | Susana Astiz Antonio Gonzalez-Bulnes Isabel Astiz Alicia Barbero Jose Luis Pesantez-Pacheco Consolacion Garcia-Contreras Marta Vazquez-Gomez Ana Heras-Molina Metformin Alleviates Obesity and Systemic Oxidative Stress in Obese Young Swine Pharmaceuticals metformin obesity oxidative-stress pediatrics |
| title | Metformin Alleviates Obesity and Systemic Oxidative Stress in Obese Young Swine |
| title_full | Metformin Alleviates Obesity and Systemic Oxidative Stress in Obese Young Swine |
| title_fullStr | Metformin Alleviates Obesity and Systemic Oxidative Stress in Obese Young Swine |
| title_full_unstemmed | Metformin Alleviates Obesity and Systemic Oxidative Stress in Obese Young Swine |
| title_short | Metformin Alleviates Obesity and Systemic Oxidative Stress in Obese Young Swine |
| title_sort | metformin alleviates obesity and systemic oxidative stress in obese young swine |
| topic | metformin obesity oxidative-stress pediatrics |
| url | https://www.mdpi.com/1424-8247/13/7/142 |
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