Pancreatic HIF2α Stabilization Leads to Chronic Pancreatitis and Predisposes to Mucinous Cystic Neoplasm
Tissue hypoxia controls cell differentiation in the embryonic pancreas, and promotes tumor growth in pancreatic cancer. The cellular response to hypoxia is controlled by the hypoxia-inducible factor (HIF) proteins, including HIF2α. Previous studies of HIF action in the pancreas have relied on loss-o...
Main Authors: | Heather K. Schofield, Manuj Tandon, Min-Jung Park, Christopher J. Halbrook, Sadeesh K. Ramakrishnan, Esther C. Kim, Jiaqi Shi, M. Bishr Omary, Yatrik M. Shah, Farzad Esni, Marina Pasca di Magliano |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2018-01-01
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Series: | Cellular and Molecular Gastroenterology and Hepatology |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2352345X17301558 |
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