Brain and gut microbiota disorders in the psychopathology of anorexia nervosa
Studies of pathophysiological mechanisms involved in eating disorders (EDs) have intensified over the past several years, revealing their unprecedented and unanticipated complexity. Results from many articles highlight critical aspects in each member of ED family. Notably, anorexia nervosa (AN) is a...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
De Gruyter
2022-12-01
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| Series: | Translational Neuroscience |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/tnsci-2022-0267 |
| _version_ | 1811171427069460480 |
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| author | Garcia-Gil Mercedes Ceccarini Maria Rachele Stoppini Fabrizio Cataldi Samuela Mazzeschi Claudia Delvecchio Elisa Albi Elisabetta Gizzi Giulia |
| author_facet | Garcia-Gil Mercedes Ceccarini Maria Rachele Stoppini Fabrizio Cataldi Samuela Mazzeschi Claudia Delvecchio Elisa Albi Elisabetta Gizzi Giulia |
| author_sort | Garcia-Gil Mercedes |
| collection | DOAJ |
| description | Studies of pathophysiological mechanisms involved in eating disorders (EDs) have intensified over the past several years, revealing their unprecedented and unanticipated complexity. Results from many articles highlight critical aspects in each member of ED family. Notably, anorexia nervosa (AN) is a disorder due to undefined etiology, frequently associated with symptoms of depression, anxiety, obsessive-compulsiveness, accompanied by endocrine alterations, altered immune response, increased inflammation, and dysbiosis of the gut microbiota. Hence, an advanced knowledge of how and why a multisystem involvement exists is of paramount importance to understand the pathogenetic mechanisms of AN. In this review, we describe the change in the brain structure/function focusing on hypothalamic endocrine disorders and the disequilibrium of gut microbiota in AN that might be responsible for the psychopathological complication. |
| first_indexed | 2024-04-10T17:13:52Z |
| format | Article |
| id | doaj.art-53f1e0586a0a4b4ab269b9a2d301dc59 |
| institution | Directory Open Access Journal |
| issn | 2081-6936 |
| language | English |
| last_indexed | 2024-04-10T17:13:52Z |
| publishDate | 2022-12-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Translational Neuroscience |
| spelling | doaj.art-53f1e0586a0a4b4ab269b9a2d301dc592023-02-05T18:11:58ZengDe GruyterTranslational Neuroscience2081-69362022-12-0113151652610.1515/tnsci-2022-0267Brain and gut microbiota disorders in the psychopathology of anorexia nervosaGarcia-Gil Mercedes0Ceccarini Maria Rachele1Stoppini Fabrizio2Cataldi Samuela3Mazzeschi Claudia4Delvecchio Elisa5Albi Elisabetta6Gizzi Giulia7Department of Biology, University of Pisa, 56127, Pisa, ItalyDepartment of Pharmaceutical Science, University of Perugia, 06126 Perugia, ItalyDepartment of Pharmaceutical Science, University of Perugia, 06126 Perugia, ItalyDepartment of Pharmaceutical Science, University of Perugia, 06126 Perugia, ItalyDepartment of Philosophy, Social Sciences and Education, University of Perugia, 06126 Perugia, ItalyDepartment of Philosophy, Social Sciences and Education, University of Perugia, 06126 Perugia, ItalyDepartment of Pharmaceutical Science, University of Perugia, 06126 Perugia, ItalyDepartment of Philosophy, Social Sciences and Education, University of Perugia, 06126 Perugia, ItalyStudies of pathophysiological mechanisms involved in eating disorders (EDs) have intensified over the past several years, revealing their unprecedented and unanticipated complexity. Results from many articles highlight critical aspects in each member of ED family. Notably, anorexia nervosa (AN) is a disorder due to undefined etiology, frequently associated with symptoms of depression, anxiety, obsessive-compulsiveness, accompanied by endocrine alterations, altered immune response, increased inflammation, and dysbiosis of the gut microbiota. Hence, an advanced knowledge of how and why a multisystem involvement exists is of paramount importance to understand the pathogenetic mechanisms of AN. In this review, we describe the change in the brain structure/function focusing on hypothalamic endocrine disorders and the disequilibrium of gut microbiota in AN that might be responsible for the psychopathological complication.https://doi.org/10.1515/tnsci-2022-0267eating disordersanorexia nervosahypothalamic disordersgut microbiota |
| spellingShingle | Garcia-Gil Mercedes Ceccarini Maria Rachele Stoppini Fabrizio Cataldi Samuela Mazzeschi Claudia Delvecchio Elisa Albi Elisabetta Gizzi Giulia Brain and gut microbiota disorders in the psychopathology of anorexia nervosa Translational Neuroscience eating disorders anorexia nervosa hypothalamic disorders gut microbiota |
| title | Brain and gut microbiota disorders in the psychopathology of anorexia nervosa |
| title_full | Brain and gut microbiota disorders in the psychopathology of anorexia nervosa |
| title_fullStr | Brain and gut microbiota disorders in the psychopathology of anorexia nervosa |
| title_full_unstemmed | Brain and gut microbiota disorders in the psychopathology of anorexia nervosa |
| title_short | Brain and gut microbiota disorders in the psychopathology of anorexia nervosa |
| title_sort | brain and gut microbiota disorders in the psychopathology of anorexia nervosa |
| topic | eating disorders anorexia nervosa hypothalamic disorders gut microbiota |
| url | https://doi.org/10.1515/tnsci-2022-0267 |
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