The Significance of Lipids to Biofilm Formation in <i>Candida albicans</i>: An Emerging Perspective
<i>Candida albicans</i>, the dimorphic opportunistic human fungal pathogen, is capable of forming highly drug-resistant biofilms in the human host. Formation of biofilm is a multistep and multiregulatory process involving various adaptive mechanisms. The ability of cells in a biofilm to...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2018-12-01
|
| Series: | Journal of Fungi |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2309-608X/4/4/140 |
| _version_ | 1819040751427780608 |
|---|---|
| author | Darakshan Alim Shabnam Sircaik Sneh Lata Panwar |
| author_facet | Darakshan Alim Shabnam Sircaik Sneh Lata Panwar |
| author_sort | Darakshan Alim |
| collection | DOAJ |
| description | <i>Candida albicans</i>, the dimorphic opportunistic human fungal pathogen, is capable of forming highly drug-resistant biofilms in the human host. Formation of biofilm is a multistep and multiregulatory process involving various adaptive mechanisms. The ability of cells in a biofilm to alter membrane lipid composition is one such adaptation crucial for biofilm development in <i>C. albicans</i>. Lipids modulate mixed species biofilm formation in vivo and inherent antifungal resistance associated with these organized communities. Cells in <i>C. albicans</i> biofilms display phase-dependent changes in phospholipid classes and in levels of lipid raft formation. Systematic studies with genetically modified strains in which the membrane phospholipid composition can be manipulated are limited in <i>C. albicans</i>. In this review, we summarize the knowledge accumulated on the impact that alterations in phospholipids may have on the biofilm forming ability of <i>C. albicans</i> in the human host. This review may provide the requisite impetus to analyze lipids from a therapeutic standpoint in managing <i>C. albicans</i> biofilms. |
| first_indexed | 2024-12-21T09:14:05Z |
| format | Article |
| id | doaj.art-53f254ee022e461cb097a6cc02f22c53 |
| institution | Directory Open Access Journal |
| issn | 2309-608X |
| language | English |
| last_indexed | 2024-12-21T09:14:05Z |
| publishDate | 2018-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Fungi |
| spelling | doaj.art-53f254ee022e461cb097a6cc02f22c532022-12-21T19:09:11ZengMDPI AGJournal of Fungi2309-608X2018-12-014414010.3390/jof4040140jof4040140The Significance of Lipids to Biofilm Formation in <i>Candida albicans</i>: An Emerging PerspectiveDarakshan Alim0Shabnam Sircaik1Sneh Lata Panwar2Yeast Molecular Genetics Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi 110067, IndiaYeast Molecular Genetics Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi 110067, IndiaYeast Molecular Genetics Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi 110067, India<i>Candida albicans</i>, the dimorphic opportunistic human fungal pathogen, is capable of forming highly drug-resistant biofilms in the human host. Formation of biofilm is a multistep and multiregulatory process involving various adaptive mechanisms. The ability of cells in a biofilm to alter membrane lipid composition is one such adaptation crucial for biofilm development in <i>C. albicans</i>. Lipids modulate mixed species biofilm formation in vivo and inherent antifungal resistance associated with these organized communities. Cells in <i>C. albicans</i> biofilms display phase-dependent changes in phospholipid classes and in levels of lipid raft formation. Systematic studies with genetically modified strains in which the membrane phospholipid composition can be manipulated are limited in <i>C. albicans</i>. In this review, we summarize the knowledge accumulated on the impact that alterations in phospholipids may have on the biofilm forming ability of <i>C. albicans</i> in the human host. This review may provide the requisite impetus to analyze lipids from a therapeutic standpoint in managing <i>C. albicans</i> biofilms.https://www.mdpi.com/2309-608X/4/4/140<i>Candida albicans</i>biofilmlipidsextracellular matrixdrug resistanceantifungal therapyflippasemixed-species biofilmplasma membranetranscription factors |
| spellingShingle | Darakshan Alim Shabnam Sircaik Sneh Lata Panwar The Significance of Lipids to Biofilm Formation in <i>Candida albicans</i>: An Emerging Perspective Journal of Fungi <i>Candida albicans</i> biofilm lipids extracellular matrix drug resistance antifungal therapy flippase mixed-species biofilm plasma membrane transcription factors |
| title | The Significance of Lipids to Biofilm Formation in <i>Candida albicans</i>: An Emerging Perspective |
| title_full | The Significance of Lipids to Biofilm Formation in <i>Candida albicans</i>: An Emerging Perspective |
| title_fullStr | The Significance of Lipids to Biofilm Formation in <i>Candida albicans</i>: An Emerging Perspective |
| title_full_unstemmed | The Significance of Lipids to Biofilm Formation in <i>Candida albicans</i>: An Emerging Perspective |
| title_short | The Significance of Lipids to Biofilm Formation in <i>Candida albicans</i>: An Emerging Perspective |
| title_sort | significance of lipids to biofilm formation in i candida albicans i an emerging perspective |
| topic | <i>Candida albicans</i> biofilm lipids extracellular matrix drug resistance antifungal therapy flippase mixed-species biofilm plasma membrane transcription factors |
| url | https://www.mdpi.com/2309-608X/4/4/140 |
| work_keys_str_mv | AT darakshanalim thesignificanceoflipidstobiofilmformationinicandidaalbicansianemergingperspective AT shabnamsircaik thesignificanceoflipidstobiofilmformationinicandidaalbicansianemergingperspective AT snehlatapanwar thesignificanceoflipidstobiofilmformationinicandidaalbicansianemergingperspective AT darakshanalim significanceoflipidstobiofilmformationinicandidaalbicansianemergingperspective AT shabnamsircaik significanceoflipidstobiofilmformationinicandidaalbicansianemergingperspective AT snehlatapanwar significanceoflipidstobiofilmformationinicandidaalbicansianemergingperspective |