Role of ocular blood flow in normal tension glaucoma
Background: Normal tension glaucoma (NTG) is a multifactorial disease in the pathogenesis of which intraocular pressure (IOP)-independent factors play a key role. Main text: There is considerable evidence that impairment of the ocular blood flow (OBF) is involved both in the onset and progression of...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2022-05-01
|
| Series: | Advances in Ophthalmology Practice and Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667376222000130 |
| _version_ | 1828346632651931648 |
|---|---|
| author | Xingdi Wu Katarzyna Konieczka Xin Liu Min Chen Ke Yao Kaijun Wang Josef Flammer |
| author_facet | Xingdi Wu Katarzyna Konieczka Xin Liu Min Chen Ke Yao Kaijun Wang Josef Flammer |
| author_sort | Xingdi Wu |
| collection | DOAJ |
| description | Background: Normal tension glaucoma (NTG) is a multifactorial disease in the pathogenesis of which intraocular pressure (IOP)-independent factors play a key role. Main text: There is considerable evidence that impairment of the ocular blood flow (OBF) is involved both in the onset and progression of this disease. With the development of the hypothesis of OBF in NTG, various imaging techniques have been developed to evaluate the OBF and blood vessels. Moreover, vascular dysregulation, which is a main factor in Flammer syndrome, was frequently observed in NTG patients. Disturbed OBF leads to increased oxidative stress, which plays an important role in the pathogenesis of glaucomatous optic neuropathy. These results suggested that IOP-independent management may provide alternative treatment options for NTG patients. Conclusions: In this review, we mainly focus on the mechanisms of the abnormal OBF in NTG. |
| first_indexed | 2024-04-14T00:29:09Z |
| format | Article |
| id | doaj.art-53f25d5f5d06433bb4653ec410907745 |
| institution | Directory Open Access Journal |
| issn | 2667-3762 |
| language | English |
| last_indexed | 2024-04-14T00:29:09Z |
| publishDate | 2022-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Advances in Ophthalmology Practice and Research |
| spelling | doaj.art-53f25d5f5d06433bb4653ec4109077452022-12-22T02:22:36ZengElsevierAdvances in Ophthalmology Practice and Research2667-37622022-05-0121100036Role of ocular blood flow in normal tension glaucomaXingdi Wu0Katarzyna Konieczka1Xin Liu2Min Chen3Ke Yao4Kaijun Wang5Josef Flammer6Eye Center of the 2nd Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, ChinaDepartment of Ophthalmology, University of Basel, Mittlere Strasse 91, Basel, 4031, SwitzerlandEye Center of the 2nd Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, ChinaEye Center of the 2nd Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, ChinaEye Center of the 2nd Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, ChinaEye Center of the 2nd Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, China; Corresponding author.Department of Ophthalmology, University of Basel, Mittlere Strasse 91, Basel, 4031, Switzerland; Corresponding author.Background: Normal tension glaucoma (NTG) is a multifactorial disease in the pathogenesis of which intraocular pressure (IOP)-independent factors play a key role. Main text: There is considerable evidence that impairment of the ocular blood flow (OBF) is involved both in the onset and progression of this disease. With the development of the hypothesis of OBF in NTG, various imaging techniques have been developed to evaluate the OBF and blood vessels. Moreover, vascular dysregulation, which is a main factor in Flammer syndrome, was frequently observed in NTG patients. Disturbed OBF leads to increased oxidative stress, which plays an important role in the pathogenesis of glaucomatous optic neuropathy. These results suggested that IOP-independent management may provide alternative treatment options for NTG patients. Conclusions: In this review, we mainly focus on the mechanisms of the abnormal OBF in NTG.http://www.sciencedirect.com/science/article/pii/S2667376222000130Normal tension glaucomaOcular blood flowVascular dysregulationFlammer syndromeOxidative stress |
| spellingShingle | Xingdi Wu Katarzyna Konieczka Xin Liu Min Chen Ke Yao Kaijun Wang Josef Flammer Role of ocular blood flow in normal tension glaucoma Advances in Ophthalmology Practice and Research Normal tension glaucoma Ocular blood flow Vascular dysregulation Flammer syndrome Oxidative stress |
| title | Role of ocular blood flow in normal tension glaucoma |
| title_full | Role of ocular blood flow in normal tension glaucoma |
| title_fullStr | Role of ocular blood flow in normal tension glaucoma |
| title_full_unstemmed | Role of ocular blood flow in normal tension glaucoma |
| title_short | Role of ocular blood flow in normal tension glaucoma |
| title_sort | role of ocular blood flow in normal tension glaucoma |
| topic | Normal tension glaucoma Ocular blood flow Vascular dysregulation Flammer syndrome Oxidative stress |
| url | http://www.sciencedirect.com/science/article/pii/S2667376222000130 |
| work_keys_str_mv | AT xingdiwu roleofocularbloodflowinnormaltensionglaucoma AT katarzynakonieczka roleofocularbloodflowinnormaltensionglaucoma AT xinliu roleofocularbloodflowinnormaltensionglaucoma AT minchen roleofocularbloodflowinnormaltensionglaucoma AT keyao roleofocularbloodflowinnormaltensionglaucoma AT kaijunwang roleofocularbloodflowinnormaltensionglaucoma AT josefflammer roleofocularbloodflowinnormaltensionglaucoma |