Mesenchymal stem/stromal cells- a principal element for tumour microenvironment heterogeneity
The heterogeneity of the tumor microenvironment (TME) is a major obstacle in cancer treatment, making most therapeutic interventions palliative rather than curative. Previous studies have suggested that the reason for the low efficacy of immunotherapy and the relapse of the original responders over...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-10-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1274379/full |
| _version_ | 1797663333614092288 |
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| author | Li Sun Yongliang Yao |
| author_facet | Li Sun Yongliang Yao |
| author_sort | Li Sun |
| collection | DOAJ |
| description | The heterogeneity of the tumor microenvironment (TME) is a major obstacle in cancer treatment, making most therapeutic interventions palliative rather than curative. Previous studies have suggested that the reason for the low efficacy of immunotherapy and the relapse of the original responders over time may be due to the complex network of mesenchymal stem/stromal cells (MSCs), a population of multipotent progenitor cells existing in a variety of tissues. Cancer-associated MSCs (CA-MSCs) have already been isolated from various types of tumors and are characterized by their vigorous pro-tumorigenic functions. Although the roles of CA-MSCs from different sources vary widely, their origins are still poorly understood. Current evidence suggests that when local resident or distally recruited MSCs interact with tumor cells and other components in the TME, “naïve” MSCs undergo genetic and functional changes to form CA-MSCs. In this review, we mainly focus on the multiple roles of CA-MSCs derived from different sources, which may help in elucidating the formation and function of the entire TME, as well as discover innovative targets for anti-cancer therapies. |
| first_indexed | 2024-03-11T19:12:59Z |
| format | Article |
| id | doaj.art-53f5f6abe5de4026ab9d46adac93eb5a |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-03-11T19:12:59Z |
| publishDate | 2023-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-53f5f6abe5de4026ab9d46adac93eb5a2023-10-09T09:18:48ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-10-011410.3389/fimmu.2023.12743791274379Mesenchymal stem/stromal cells- a principal element for tumour microenvironment heterogeneityLi SunYongliang YaoThe heterogeneity of the tumor microenvironment (TME) is a major obstacle in cancer treatment, making most therapeutic interventions palliative rather than curative. Previous studies have suggested that the reason for the low efficacy of immunotherapy and the relapse of the original responders over time may be due to the complex network of mesenchymal stem/stromal cells (MSCs), a population of multipotent progenitor cells existing in a variety of tissues. Cancer-associated MSCs (CA-MSCs) have already been isolated from various types of tumors and are characterized by their vigorous pro-tumorigenic functions. Although the roles of CA-MSCs from different sources vary widely, their origins are still poorly understood. Current evidence suggests that when local resident or distally recruited MSCs interact with tumor cells and other components in the TME, “naïve” MSCs undergo genetic and functional changes to form CA-MSCs. In this review, we mainly focus on the multiple roles of CA-MSCs derived from different sources, which may help in elucidating the formation and function of the entire TME, as well as discover innovative targets for anti-cancer therapies.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1274379/fulltumor microenvironmentheterogeneitycancer-associated mesenchymal stem/stromal cellsstemnessimmune cells |
| spellingShingle | Li Sun Yongliang Yao Mesenchymal stem/stromal cells- a principal element for tumour microenvironment heterogeneity Frontiers in Immunology tumor microenvironment heterogeneity cancer-associated mesenchymal stem/stromal cells stemness immune cells |
| title | Mesenchymal stem/stromal cells- a principal element for tumour microenvironment heterogeneity |
| title_full | Mesenchymal stem/stromal cells- a principal element for tumour microenvironment heterogeneity |
| title_fullStr | Mesenchymal stem/stromal cells- a principal element for tumour microenvironment heterogeneity |
| title_full_unstemmed | Mesenchymal stem/stromal cells- a principal element for tumour microenvironment heterogeneity |
| title_short | Mesenchymal stem/stromal cells- a principal element for tumour microenvironment heterogeneity |
| title_sort | mesenchymal stem stromal cells a principal element for tumour microenvironment heterogeneity |
| topic | tumor microenvironment heterogeneity cancer-associated mesenchymal stem/stromal cells stemness immune cells |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1274379/full |
| work_keys_str_mv | AT lisun mesenchymalstemstromalcellsaprincipalelementfortumourmicroenvironmentheterogeneity AT yongliangyao mesenchymalstemstromalcellsaprincipalelementfortumourmicroenvironmentheterogeneity |