Effects of Averrhoa Carambola Hydro-Alcoholic Extract on Liver Histopathological Changes in Rats with a High-Fat Diet
Background & Objective: In the present study the effects of Averrhoa carambola fruit hydro-alcoholic extract on hepatic tissue, liver enzymes, and serum lipids were investigated in rats submitted to a high-fat diet. Materials & Methods: In this experimental study, 30 male Wistar rats were ra...
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| Format: | Article |
| Language: | English |
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Fasa University of Medical Sciences
2019-11-01
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| Series: | Journal of Advanced Biomedical Sciences |
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| Online Access: | http://jabs.fums.ac.ir/article-1-1955-en.pdf |
| _version_ | 1797679554612953088 |
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| author | Iman shahraki abbas Jamshidian Mohammad Reza Hajinezhad mohammad Ebrahim Akbari aida davari |
| author_facet | Iman shahraki abbas Jamshidian Mohammad Reza Hajinezhad mohammad Ebrahim Akbari aida davari |
| author_sort | Iman shahraki |
| collection | DOAJ |
| description | Background & Objective: In the present study the effects of Averrhoa carambola fruit hydro-alcoholic extract on hepatic tissue, liver enzymes, and serum lipids were investigated in rats submitted to a high-fat diet.
Materials & Methods: In this experimental study, 30 male Wistar rats were randomly divided to 3 equal groups as follows: (1) control, (2) rats fed a high-fat diet and (3) rats receiving a high fat diet and hydro-alcoholic extract of Averrhoa carambola (A. carambola) at a dose of (200 mg/kg bw). Rats received a high-fat diet for one month. Then, two rats were selected from each diet group and hyperlipidemia was confirmed by measurement of serum triglyceride and serum cholesterol levels. After confirming hyperlipidemia, rats of group 3 were orally treated by Averrhoa carambola (200 mg/kg bw) for 21 days. At the end of the experiment, serum liver enzymes, serum cholesterol and triglyceride levels were assayed. Afterward, for histopathological investigation, hepatic tissue samples were prepared and routine tissue processing protocol was performed.
Results: The administration of Averrhoa carambola fruit extract significantly reduced serum triglyceride and cholesterol when compared with the hyperlipidemic group (P < 0.05 and P < 0.001 respectively). Serum ALT and AST in rats that received Averrhoa carambola fruit extract significantly decreased compared to hyperlipidemic group (P< 0.05). In the histopathological examination, degeneration, vacuolation and intra-cytoplasmic accumulations in the treated group were improved in comparison with the hyperlipidemic group.
Conclusion: These results showed that the Averrhoa carambola fruit extract can protect against hyperlipidemia- induced liver damage in rats. |
| first_indexed | 2024-03-11T23:16:29Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2228-5105 2783-1523 |
| language | English |
| last_indexed | 2024-03-11T23:16:29Z |
| publishDate | 2019-11-01 |
| publisher | Fasa University of Medical Sciences |
| record_format | Article |
| series | Journal of Advanced Biomedical Sciences |
| spelling | doaj.art-53f82dd82bea4db5a91ae07785c701b72023-09-20T21:26:56ZengFasa University of Medical SciencesJournal of Advanced Biomedical Sciences2228-51052783-15232019-11-019418961902Effects of Averrhoa Carambola Hydro-Alcoholic Extract on Liver Histopathological Changes in Rats with a High-Fat DietIman shahraki0abbas Jamshidian1Mohammad Reza Hajinezhad2mohammad Ebrahim Akbari3aida davari4 Department of Pathobiology, Faculty of Veterinary Medicine, University Of Zabol, Zabol, Iran Department of Pathobiology, Faculty of Veterinary Medicine, University Of Zabol, Zabol, Iran Department of Basic Science, Faculty of Veterinary Medicine, University Of Zabol, Zabol, Iran Department of Basic Science, Faculty of Veterinary Medicine, University Of Zabol, Zabol, Iran Department of Pathobiology, Faculty of Veterinary Medicine, University Of Zabol, Zabol, Iran Background & Objective: In the present study the effects of Averrhoa carambola fruit hydro-alcoholic extract on hepatic tissue, liver enzymes, and serum lipids were investigated in rats submitted to a high-fat diet. Materials & Methods: In this experimental study, 30 male Wistar rats were randomly divided to 3 equal groups as follows: (1) control, (2) rats fed a high-fat diet and (3) rats receiving a high fat diet and hydro-alcoholic extract of Averrhoa carambola (A. carambola) at a dose of (200 mg/kg bw). Rats received a high-fat diet for one month. Then, two rats were selected from each diet group and hyperlipidemia was confirmed by measurement of serum triglyceride and serum cholesterol levels. After confirming hyperlipidemia, rats of group 3 were orally treated by Averrhoa carambola (200 mg/kg bw) for 21 days. At the end of the experiment, serum liver enzymes, serum cholesterol and triglyceride levels were assayed. Afterward, for histopathological investigation, hepatic tissue samples were prepared and routine tissue processing protocol was performed. Results: The administration of Averrhoa carambola fruit extract significantly reduced serum triglyceride and cholesterol when compared with the hyperlipidemic group (P < 0.05 and P < 0.001 respectively). Serum ALT and AST in rats that received Averrhoa carambola fruit extract significantly decreased compared to hyperlipidemic group (P< 0.05). In the histopathological examination, degeneration, vacuolation and intra-cytoplasmic accumulations in the treated group were improved in comparison with the hyperlipidemic group. Conclusion: These results showed that the Averrhoa carambola fruit extract can protect against hyperlipidemia- induced liver damage in rats.http://jabs.fums.ac.ir/article-1-1955-en.pdfhyperlipidemialiveraverrhoa carambolarats |
| spellingShingle | Iman shahraki abbas Jamshidian Mohammad Reza Hajinezhad mohammad Ebrahim Akbari aida davari Effects of Averrhoa Carambola Hydro-Alcoholic Extract on Liver Histopathological Changes in Rats with a High-Fat Diet Journal of Advanced Biomedical Sciences hyperlipidemia liver averrhoa carambola rats |
| title | Effects of Averrhoa Carambola Hydro-Alcoholic Extract on Liver Histopathological Changes in Rats with a High-Fat Diet |
| title_full | Effects of Averrhoa Carambola Hydro-Alcoholic Extract on Liver Histopathological Changes in Rats with a High-Fat Diet |
| title_fullStr | Effects of Averrhoa Carambola Hydro-Alcoholic Extract on Liver Histopathological Changes in Rats with a High-Fat Diet |
| title_full_unstemmed | Effects of Averrhoa Carambola Hydro-Alcoholic Extract on Liver Histopathological Changes in Rats with a High-Fat Diet |
| title_short | Effects of Averrhoa Carambola Hydro-Alcoholic Extract on Liver Histopathological Changes in Rats with a High-Fat Diet |
| title_sort | effects of averrhoa carambola hydro alcoholic extract on liver histopathological changes in rats with a high fat diet |
| topic | hyperlipidemia liver averrhoa carambola rats |
| url | http://jabs.fums.ac.ir/article-1-1955-en.pdf |
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